Intravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian model of rats: Focusing on neuroprotective effects of stromal cell-derived factor-1α

Background

Junctional adhesion molecule-A (JAM-A) is an adhesive protein expressed in various cell types. JAM-A localizes to the tight junctions between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesion and to the control of paracellular permeability.

Results

So far, the expression pattern of JAM-A has not been described in detail for the different cell types of the adult brain. Here we show that a subset of proliferating cells in the adult mouse brain express JAM-A. We further clarify that these cells belong to the lineage of NG2-glia cells. Although these mitotic NG2-glia cells express JAM-A, the protein never shows a polarized subcellular distribution. Also non-mitotic NG2-glia cells express JAM-A in a non-polarized pattern on their surface.

Conclusions

Our data show that JAM-A is a novel surface marker for NG2-glia cells of the adult brain.     

Single-shot femtosecond electron diffraction with laser-accelerated electrons: experimental demonstration of electron pulse compression

We report the first experimental demonstration of longitudinal compression of laser-accelerated electron pulses. Accelerated by a femtosecond laser pulse with an intensity of 101? W/cm2, an electron pulse with an energy of around 350 keV and a relative momentum spread of about 10?2 was compressed to a 500-fs pulse at a distance of about 50 cm from the electron source by using a magnetic pulse compressor. This pulse was used to generate a clear diffraction pattern of a gold crystal in a single shot. This method solves the space-charge problem in ultrafast electron diffraction.     

Experimental study of thermal noise caused by an inhomogeneously distributed loss

The thermal fluctuation of a mechanical system with an inhomogeneously distributed loss was measured to prove the invalidity of the normal-mode expansion method which is commonly used to calculate the thermal noise of mechanical oscillators. The measured spectrum is inconsistent with the modal expansion model, while they agree well with an evaluation obtained by applying the fluctuation-dissipation theorem to the measured mechanical response. These are the first experimental results which show that mode expansion is invalid.     

Addition of Phenylacetylene to a P--C Bond of Phosphorus-Bridged [1]Ferrocenophane

A reaction of CpMn(CO) 2 (fcpp) (fcpp = 1,1'-ferrocenediylphenylphosphine) with Pt(PPh 3 ) 4 gave an Mn-Pt dinuclear complex, which reacted with HC L CPh to give CpMn(CO) 2 {PPh(ferroccene)(C L CPh)}.     

Potentiometrie

Ohne Zusammenfassung     

Integration of the cleanup process: pretreatment of polycyclic aromatic hydrocarbons from diesel exhaust particles on silica gel beads in a microchannel.

This paper presents an integrated microfluidic system that performs cleanup for polycyclic aromatic hydrocarbons (PAHs) from diesel exhaust particles on silica gel beads in a microchip. A column chromatography phase was constructed by filling the silica gel beads into a microchannel that had a dam structure 25 microm high. The height of the dam structure was determined according to the rate of the wet etching. This work on the cleanup of PAHs from diesel exhaust particles showed that the microchip-based system has the same performance as the conventional method on the solid phase extraction column and has some advantages, such as less reagent consumption and shorter pretreatment time, over the conventional method.     

Synthesis and properties of poly(carbonate‐co‐ester)s obtained by cationic ring‐opening copolymerization of spiroorthocarbonate and ε‐caprolactone

Cationic ring‐opening copolymerization behavior of 1,5,7,11‐tetraoxaspiro[5.5]undecane (SOC1) and ε‐caprolactone (CL), and the thermal behavior of the obtained copolymers are described. When SOC1 and CL were cationically copolymerized under various feed ratios using BF₃OEt₂ as the initiator in CH₂Cl₂ at 25 °C, the corresponding copolymers were obtained in 77–99% yields. The ¹H NMR spectroscopic analysis of the copolymers revealed that the copolymer compositions were almost identical to the feed ratios, and the diad ratios of SOC1–SOC1/SOC1–CL and CL–SOC1/CL–CL are 48.0/52.0 and 54.3/45.7. These observations proved the random structures of the copolymers without containing the long blocks of the homopolymer sequences. Differential scanning calorimetric (DSC) analysis revealed that the melting points and melting entharpies decreased with the increase of the SOC1 unit compositions, suggesting that the copolymers gain flexibility as the SOC1 unit increases. © 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 2937–2942, 2006