全文获取类型
收费全文 | 3002篇 |
免费 | 89篇 |
国内免费 | 9篇 |
专业分类
化学 | 2014篇 |
晶体学 | 52篇 |
力学 | 57篇 |
数学 | 460篇 |
物理学 | 517篇 |
出版年
2022年 | 52篇 |
2021年 | 74篇 |
2020年 | 66篇 |
2019年 | 60篇 |
2018年 | 47篇 |
2017年 | 57篇 |
2016年 | 86篇 |
2015年 | 85篇 |
2014年 | 101篇 |
2013年 | 197篇 |
2012年 | 162篇 |
2011年 | 192篇 |
2010年 | 148篇 |
2009年 | 125篇 |
2008年 | 182篇 |
2007年 | 154篇 |
2006年 | 131篇 |
2005年 | 130篇 |
2004年 | 115篇 |
2003年 | 97篇 |
2002年 | 85篇 |
2001年 | 33篇 |
2000年 | 42篇 |
1999年 | 33篇 |
1998年 | 27篇 |
1997年 | 34篇 |
1996年 | 30篇 |
1995年 | 32篇 |
1994年 | 24篇 |
1993年 | 21篇 |
1992年 | 31篇 |
1991年 | 40篇 |
1990年 | 32篇 |
1989年 | 23篇 |
1988年 | 24篇 |
1987年 | 17篇 |
1986年 | 18篇 |
1985年 | 30篇 |
1984年 | 27篇 |
1983年 | 13篇 |
1982年 | 20篇 |
1981年 | 14篇 |
1980年 | 26篇 |
1979年 | 13篇 |
1978年 | 19篇 |
1977年 | 22篇 |
1976年 | 19篇 |
1975年 | 9篇 |
1974年 | 9篇 |
1973年 | 9篇 |
排序方式: 共有3100条查询结果,搜索用时 31 毫秒
111.
W. Kwiatkowski J. Karolak-wojciechowska 《SAR and QSAR in environmental research》2013,24(2-3):233-244
Abstract The present study was performed on a group of 27 derivatives of phenylsuccinimides, of which only 12 were active against maximal electrical shock in spite of the structural similarities of these compounds. The work consisted of four main parts: 1. crystallographic investigations of a subset of chosen compounds; 2. conformational analysis of characteristic molecules from the investigated series, performed by means of molecular mechanics calculations; 3. molecular orbital optimization of all the molecules using the MNDO method starting with conformations obtained in 2; 4. molecular electrostatic potential (MEP) analysis which was performed on the semiempirical (MNDO) and ab initio levels. This research showed that MEP maps provide a signature that distinguishes between active and inactive compounds. There are MEP minima close to the two carbonyl oxygens of the imide ring, and although the magnitude of the difference between the two minima is approximately constant, the sign of the difference provides an activity index. The initial orientations of phenylsuccinimide molecules in relation to the receptor are not equivalent and they depend on the potential distribution around both the succinimide molecules and around the receptor. In the active compounds the negative potential difference at the discussed points most probably influences the initial set-up of the molecules in relation to the receptor and results in a considerably higher probability of the molecules being bound at the right place on the receptor. 相似文献
112.
113.
Matúš Durec Francesco Zaccaria Dr. Célia Fonseca Guerra Prof. Dr. Radek Marek 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(31):10912-10922
Repetitive guanine‐rich nucleic acid sequences play a crucial role in maintaining genome stability and the cell life cycle and represent potential targets for regulatory drugs. Recently, it has been demonstrated that guanine‐based ligands with a porphyrin core can be used as markers of G‐quadruplex assemblies in cell tissues. Herein, model systems of guanine‐based ligands are explored by DFT methods. The energies of formation of modified guanine tetrads and those of modified tetrads stacked on the top of natural guanine tetrads have been calculated. The interaction energy has been decomposed into contributions from hydrogen bonding, stacking, and ion coordination and a twist–rise potential energy scan has been performed to find the individual local minima. Energy decomposition analysis reveals the impact of various substituents (F, Cl, Br, I, Me, NMe2) on individual energy terms. In addition, cooperative reinforcement in forming the modified and stacked tetrads, as well as the frontier orbitals participating in the hydrogen‐bonding framework involving the HOMO–LUMO gap between the occupied σHOMO on the proton‐accepting C=O and =N? groups and unoccupied σLUMO on the N?H groups, has been studied. The investigated systems are demonstrated to have a potential in ligand development, mainly due to stacking enhancement compared with natural guanine, which is used as a reference. 相似文献
114.
Rafa? Janus Piotr Natkański Anna Wach Marek Drozdek Zofia Piwowarska Pegie Cool Piotr Ku?trowski 《Journal of Thermal Analysis and Calorimetry》2012,110(1):119-125
Thermogravimetry, diffuse reflectance infrared Fourier transform spectroscopy, and X-ray photoelectron spectroscopy (XPS) were used for the studying of thermally induced structural changes of polyacrylonitrile (PAN) deposited on the surface of SBA-15 type mesoporous silica. Polymer was introduced onto the support by the precipitation polymerization of acrylonitrile in aqueous suspension of SBA-15. Low temperature transformation (to 723?K) of the deposited PAN was analyzed. It was found that at about 523?K, exothermic cyclization of polymer chains to the so-called ladder form of PAN occurred. However, the total cyclization of PAN required higher carbonization temperatures, at which gradual dehydrogenation followed by graphitization was initiated. XPS revealed that the cyclic form of PAN and a relatively large amount of carbonyl species, formed during the carbonization of the PAN/SBA-15 composite at 623?K, were responsible for the high sorption capacity in the methyl?Cethyl ketone (MEK) vapor elimination. The efficiency in the MEK adsorption was also influenced by the content of PAN-derived carbon deposited on the SBA-15 surface. 相似文献
115.
Góźdź Marek Góźdź Andrzej Gusev Alexander A. Vinitsky Sergue I. 《Physics of Atomic Nuclei》2018,81(6):853-857
Physics of Atomic Nuclei - We discuss the problem of the time variable in the nearly standard formulation of the quantum mechanics. In order to be able to describe the outcome of some of the... 相似文献
116.
Ewa Kłodzińska Wojciech Kupczyk Marek Jackowski Boguslaw Buszewski 《Electrophoresis》2013,34(22-23):3206-3213
A surgical site infection (SSI) is an infection that occurs after surgery in the part of the body where the surgery took place. An SSI may range from a spontaneously limited wound discharge within 7–10 days of an operation to a life‐threatening postoperative complication, such as a sternal infection after open heart surgery. Most SSIs are caused by contamination of an incision with microorganisms from the patient's own body during surgery. From the analytical point of view, the complex nature of these samples as well as the low concentrations of analytes require a system with high sensitivity and efficiency. Such situation requires a technique such as CE, which is a powerful and versatile separation technique that promises to rival HPLC when applied to the separation of both charged and neutral species. During the study, it has been demonstrated that CZE identifies characteristics of such groups of pathogens such as bacteria Gram (+) and different species of bacteria Gram (?), and also develops weekly individual profiles for patients after application of antibiotics. This was done in order to show the impact of antibiotic therapy in change “numbers” of bacteria present in the wound after surgery. The method proved to be the ideal straight specificity in the case of Escherichia coli (100%). Finally, analysis of the spectra and the second derivatives of the UV‐Vis spectra confirmed the similarity in the profiles and showed that the CZE is a great method for fast screening test in bacterial infection. 相似文献
117.
118.
119.
120.
Szymon Godlewski Jakub S. Prauzner-Bechcicki Janusz Budzioch Lukasz Walczak Irena G. Stará Ivo Starý Petr Sehnal Marek Szymonski 《Surface science》2012,606(21-22):1600-1607
Helicenes are carbon-rich materials with an ordered structure that possess interesting and remarkable electronic, chiroptical, mechanical and magnetic properties either in bulk or as single molecule devices. We report on the first attempt to anchor and organize [11]anthrahelicene ([11]AH) molecules onto a metal oxide surface. Molecular structures obtained on the (110) and (011) faces of rutile titania are characterized using scanning probe microscopy. On the (110) surface, [11]AH molecules form islands that are comprised of small domains of two types that are mirror reflections of each other and have an ordered quasi-hexagonal lattice. In contrast, molecules form unordered clusters on the (011) surface. Single molecules on both faces are imaged with sub-molecular resolution. 相似文献