Recent progress in tissue optical clearing

Tissue optical clearing technique provides a prospective solution for the application of advanced optical methods in life sciences. This paper gives a review of recent developments in tissue optical clearing techniques. The physical, molecular and physiological mechanisms of tissue optical clearing are overviewed and discussed. Various methods for enhancing penetration of optical‐clearing agents into tissue, such as physical methods, chemical‐penetration enhancers and combination of physical and chemical methods are introduced. Combining the tissue optical clearing technique with advanced microscopy image or labeling technique, applications for 3D microstructure of whole tissues such as brain and central nervous system with unprecedented resolution are demonstrated. Moreover, the difference in diffusion and/or clearing ability of selected agents in healthy versus pathological tissues can provide a highly sensitive indicator of the tissue health/pathology condition. Finally, recent advances in optical clearing of soft or hard tissue for in vivo imaging and phototherapy are introduced.     

Total synthesis of deoxymannojirimycin and d-mannolactam via carbonylation of 5-vinyloxazolidin-2-ones

The stereoselective synthesis of piperidine alkaloids deoxymannojirimycin and d-mannolactam from d-serine has been achieved. The key step involves palladium-catalysed decarboxylative carbonylation of a serine-derived 5-vinyloxazolidin-2-one to give 6-(tert-butyldimethylsilyloxymethyl)-3,6-dihydro-1H-pyridin-2-one which was subsequently converted into the title compounds.     

Double decomposition reaction of sodium salt of phenylhydroxysilane with aluminum sulfate

Conclusions A study was made of the double decomposition reaction of the sodium salt of phenylhydroxysilane with aluminum sulfate and it was shown that insoluble polyaluminophenylsiloxanes are obtained in water-toluene medium, while soluble polyaluminophenylsiloxanes are obtained in water-toluene-acetone medium.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 12, pp. 2834–2836, December, 1976.     

The attenuation of the higher-order cross-section modes in a duct with a thin porous layer

A numerical method for sound propagation of higher-order cross-sectional modes in a duct of arbitrary cross-section and boundary conditions with nonzero, complex acoustic admittance has been considered. This method assumes that the cross-section of the duct is uniform and that the duct is of a considerable length so that the longitudinal modes can be neglected. The problem is reduced to a two-dimensional (2D) finite element (FE) solution, from which a set of cross-sectional eigen-values and eigen-functions are determined. This result is used to obtain the modal frequencies, velocities and the attenuation coefficients. The 2D FE solution is then extended to three-dimensional via the normal mode decomposition technique. The numerical solution is validated against experimental data for sound propagation in a pipe with inner walls partially covered by coarse sand or granulated rubber. The values of the eigen-frequencies calculated from the proposed numerical model are validated against those predicted by the standard analytical solution for both a circular and rectangular pipe with rigid walls. It is shown that the considered numerical method is useful for predicting the sound pressure distribution, attenuation, and eigen-frequencies in a duct with acoustically nonrigid boundary conditions. The purpose of this work is to pave the way for the development of an efficient inverse problem solution for the remote characterization of the acoustic boundary conditions in natural and artificial waveguides.     

Satellite band in the rovibrational spectrum of CO2 in helium droplets

Pulsed infrared (nu approximately 2350 cm(-1)) laser excitation spectra of CO2 molecules embedded in helium droplets are reported. The spectra exhibit a sharp R(0) rovibrational line accompanied by a weak broader (deltanu approximately 10 cm(-1)) satellite band, which is shifted by 14 cm(-1) towards higher frequencies. We assign this satellite band to a simultaneous rovibrational excitation of a molecule and its helium solvation shell. The results are rationalized within a model, which includes coupling of the rotational states of a molecule and a ring of He atoms.     

Effect of vorticity production on the structure and velocity of curved flames

A nonlinear equation describing curved stationary flames with arbitrary gas expansion theta = rho(fuel)/rho(burnt) is obtained in a closed form without an assumption of weak nonlinearity. The equation respects all conservation laws and takes into account vorticity production in the flame. In the scope of the asymptotic expansion for theta -->1, the new equation solves the problem of stationary flame propagation with accuracy of the sixth order in theta - 1. Its analytical solutions give the flame velocity in tubes of arbitrary width, which agrees with available results of direct numerical modeling.     

Semileptonic b-->u decays: lepton invariant mass spectrum

We compute O(alpha(2)(s)) QCD corrections to the lepton invariant mass spectrum in the decay b-->ulnu(l), relevant for the determination of the Cabibbo-Kobayashi-Maskawa matrix element /V(ub)/. Our method can also be used to evaluate moments of the lepton energy distribution with an O(alpha(2)(s)) accuracy. The Abelian part of our result gives the neutrino invariant mass spectrum in the muon decay and, upon integration, the O(alpha(2)) correction to the muon lifetime.     

Synthesis of phenanthro[1,2-d]azepine derivatives containing a new heterocyclic system from the aporphine alkaloid glaucine

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