Preparation process for improving cathode electrode structure in direct methanol fuel cell

The cathode electrode structure of the direct methanol fuel cell (DMFC) was improved by a novel catalyst ink preparation method. Regulation of the solvent polarity in the cathode catalyst ink caused increases in the electrochemical active surface (EAS) for the oxygen reduction reaction (ORR) as well as decreases in the methanol crossover effect. In a two-step preparation, agglomerates consisting of catalyst and Nafion ionomers were decreased in size, and polar groups in the ionomers formed organized networks in the cathode catalyst layer. Despite Pt catalysts in the cathode being only 0.5 mg cm^? 2, the maximum power density of the improved membrane electrode assembly (MEA) was 120 mW cm^? 2, at 3 M methanol, which was much larger than that of traditional MEA (67 mW cm^? 2).     

The roles of phytochemicals in bronchial asthma

Despite gaps in our knowledge of how phytochemicals interfere with cellular functions, several natural plant products are utilized to prevent or treat a wide range of diseases. Identification of an agent with therapeutic potential requires multiple steps involving in vitro studies, efficacy and toxicity studies in animal models, and then human clinical trials. This review provides a brief introduction on natural products that may help to treat and/or prevent bronchial asthma and describes our current understanding of their molecular mechanisms based on various in vitro, in vivo, and clinical studies. We focus on the anti-inflammatory and anti-vascular actions of the plant products and other roles beyond the anti-oxidative effects.     

The dynamics of a double carbon nanotube charge qubit embedded in a suspended phonon cavity

We propose a novel quantum device in which a double carbon nanotube is embedded inside a suspended semiconductor slab. We theoretically investigate, in terms of a perturbation treatment based on a unitary transformation, the dynamics of the charge qubit in relation to the device. The phonon-induced decoherence and the quality of the qubit are analyzed in detail after a derivation of the phonon spectral density. It is shown that a charge qubit of high quality can be obtained due to the inhibition of the electron–phonon coupling in the confined structure of the slab, suggesting that the novel quantum device is a good candidate for quantum information processing.     

The high-frequency description of scatter of a plane compressional wave by an elliptic crack

High-frequency approximations that can be interpreted in terms of the Uniform Geometrical Theory of Diffraction (UGTD) and Uniform Kirchhoff Approximation (UKA) are used to develop a code for modeling ultrasonic scatter of a plane compressional wave by an elliptic crack in the radiating near field. The approximations are intercompared and partially validated against a direct numerical code based on an FD (Finite-Difference) scheme. At present, in many realistic situations the approximate codes of the type described here offer the only viable simulation tool; purely numeric codes are not only much slower, they still require too much computer memory to simulate the complex structure of the radiating near fields.     

A variational phase field method for curve smoothing

A variational phase field model is proposed for curve smoothing, in which a weight function is associated with the similarity measure term in the model so that important geometric features could be well preserved. Finite element approximation of the proposed model is given for its numerical implementation. Since the model has a linear weak variational form, the discretized system could be solved efficiently by many existing solution techniques. An effective algorithm is also developed, for the purpose of feature preservation, to automatically determine the weight from the given data. Various numerical examples are presented to demonstrate effectiveness and robustness of the proposed method.     

Direct Electrochemistry of Hemoglobin Immobilized on Colloidal Gold‐Hydroxyapatite Nanocomposite for Electrocatalytic Detection of Hydrogen Peroxide

A novel nanocomposite of colloidal gold (GNPs) and hydroxyapatite nanotubes (Hap) was prepared for immobilization of a redox protein, hemoglobin (Hb), on glassy carbon electrode. The immobilized Hb showed fast direct electron transfer and excellent electrocatalytic behavior toward reduction of hydrogen peroxide. A synergic effect between GNPs and Hap for accelerating the surface electron transfer of Hb was observed, which led to a pair of redox peaks with a formal potential of (?340±2) mV at pH 7.0, and a new biosensor for hydrogen peroxide with a linear range from 0.5 to 25 μM and a limit of detection of 0.2 μM at 3σ. Owing to the good biocompatibility of the nanocomposite, the biosensor exhibited good stability and acceptable reproducibility. The as‐prepared nanocomposite film provided a good matrix for protein immobilization and biosensor preparation.     

Modulation of protective immunity against herpes simplex virus via mucosal genetic co-transfer of DNA vaccine with ��2-adrenergic agonist

Cholera toxin, which has been frequently used as mucosal adjuvant, leads to an irreversible activation of adenylyl cyclase, thereby accumulating cAMP in target cells. Here, it was assumed that β₂-adrenergic agonist salbutamol may have modulatory functions of immunity induced by DNA vaccine, since β₂-adrenergic agonists induce a temporary cAMP accumulation. To test this assumption, the present study evaluated the modulatory functions of salbutamol co-administered with DNA vaccine expressing gB of herpes simplex virus (HSV) via intranasal (i.n.) route. We found that the i.n. co-administration of salbutamol enhanced gB-specific IgG and IgA responses in both systemic and mucosal tissues, but optimal dosages of co-administered salbutamol were required to induce maximal immune responses. Moreover, the mucosal co-delivery of salbutamol with HSV DNA vaccine induced T_h2-biased immunity against HSV antigen, as evidenced by IgG isotypes and T_h1/T_h2-type cytokine production. The enhanced immune responses caused by co-administration of salbutamol provided effective and rapid responses to HSV mucosal challenge, thereby conferring prolonged survival and reduced inflammation against viral infection. Therefore, these results suggest that salbutamol may be an attractive adjuvant for mucosal genetic transfer of DNA vaccine.     

Photolysis of o‐Nitrobenzaldehyde in the Gas Phase: A New OH. Formation Channel

New route to gas‐phase OH^. : UV photolysis of gaseous o‐nitrobenzaldehyde forms OH radicals via the transformation into the ketene or o‐nitrosobenzoic acid intermediate (see figure). The OH^. product is monitored by single‐photon laser‐induced fluorescence (LIF).

     

Synthesis of Polynucleotide Modified Gold Nanoparticles as a High Potent Anti‐Cancer Drug Carrier

Gold nanoparticles have been developed for the photoacoustic imaging, delivery of genes and laser induced photothermal therapy. In this study, we have developed oligonucleotide conjugated gold nanoparticles as the carrier for simultaneous DNA and anti‐cancer nucleoside delivery. The polynucleotidenanoparticle complex presented higher capacity in carrying 5‐FU anti‐cancer compounds than the original gold particles. The hydrodynamic size of the gold nanoparticles increased from 25 to 35 nm with an increase in the negative surface charge from ?9.58 to 21.66 mV after polynucleotide conjugation and drug loading. A positive association between environmental pH and drug release was observed in PBS, which implied their potential use in the controlled localized drug release in the lower GI tract. The MTT assay revealed dose dependent cytotoxicity to colon cancer cell line than free compounds. These results suggest the potential use of this new polynucleotide‐gold nanoparticles complex as the environmental controlled anti‐cancer nanocapsule, especially suitable for per oral colon cancer chemotherapy.     

Coordinating a supply chain with effort and price dependent stochastic demand

This paper investigates the issue of channel coordination for a supply chain facing stochastic demand that is sensitive to both sales effort and retail price. In the standard newsvendor setting, the returns policy and the revenue sharing contract have been shown to be able to align incentives of the supply chain’s members so that the decentralized supply chain behaves as well as the integrated one. When the demand is influenced by both retail price and retailer sales effort, none of the above traditional contracts can coordinate the supply chain. To resolve this issue, we explore a variety of other contract types including joint return policy with revenue sharing contract, return policy with sales rebate and penalty (SRP) contract, and revenue sharing contract with SRP. We find that only the properly designed returns policy with SRP contract is able to achieve channel coordination and lead to a Pareto improving win–win situation for supply chain members. We then provide analytical method to determine the contract parameters and finally we use a numerical example to illustrate the findings and gain more insights.