全文获取类型
收费全文 | 3497篇 |
免费 | 108篇 |
国内免费 | 2篇 |
专业分类
化学 | 2647篇 |
晶体学 | 49篇 |
力学 | 34篇 |
数学 | 148篇 |
物理学 | 729篇 |
出版年
2023年 | 23篇 |
2022年 | 28篇 |
2021年 | 39篇 |
2020年 | 41篇 |
2019年 | 51篇 |
2018年 | 37篇 |
2017年 | 33篇 |
2016年 | 72篇 |
2015年 | 61篇 |
2014年 | 70篇 |
2013年 | 172篇 |
2012年 | 150篇 |
2011年 | 188篇 |
2010年 | 97篇 |
2009年 | 102篇 |
2008年 | 209篇 |
2007年 | 204篇 |
2006年 | 190篇 |
2005年 | 228篇 |
2004年 | 189篇 |
2003年 | 138篇 |
2002年 | 148篇 |
2001年 | 91篇 |
2000年 | 64篇 |
1999年 | 34篇 |
1998年 | 46篇 |
1997年 | 32篇 |
1996年 | 53篇 |
1995年 | 23篇 |
1994年 | 32篇 |
1993年 | 26篇 |
1992年 | 29篇 |
1991年 | 35篇 |
1990年 | 29篇 |
1989年 | 32篇 |
1988年 | 31篇 |
1987年 | 27篇 |
1986年 | 25篇 |
1985年 | 56篇 |
1984年 | 49篇 |
1983年 | 33篇 |
1982年 | 45篇 |
1981年 | 42篇 |
1980年 | 40篇 |
1979年 | 43篇 |
1978年 | 43篇 |
1977年 | 24篇 |
1976年 | 35篇 |
1975年 | 23篇 |
1974年 | 19篇 |
排序方式: 共有3607条查询结果,搜索用时 31 毫秒
31.
32.
1-Alkoxy-3-trimethylsilylmethyl- and 1-alkoxy-3-trimethylsilyl-l,3-butadienes () were newly prepared. The cycloaddition reactions of with various dienophiles including heterodienophiles were found to proceed very smoothly in a perfectly regiospecific mode. 相似文献
33.
34.
35.
Nagaoka Y Inoue H el-Koussi N Tomioka K 《Chemical communications (Cambridge, England)》2002,(2):122-123
Upon treatment with lithium diisopropylamide achiral and chiral alpha,beta,psi,omega-unsaturated bisphosphine oxides underwent lithiation-conjugate addition tandem cyclization to afford the corresponding endo-alpha,beta-unsaturated cyclic bisphosphine oxides; sequential stereoselective reduction of the cyclized bisphosphine oxide gave the corresponding trans- and cis-bisphosphines that were successfully applicable in a catalytic asymmetric hydrogenation as chiral bisphosphine ligands. 相似文献
36.
Antiviral activity of natural occurring flavonoids in vitro 总被引:2,自引:0,他引:2
Y Tsuchiya M Shimizu Y Hiyama K Itoh Y Hashimoto M Nakayama T Horie N Morita 《Chemical & pharmaceutical bulletin》1985,33(9):3881-3886
37.
The controlled Smith degradation of ukonan A, a phagocytosis-activating polysaccharide isolated from the rhizome of Curcuma longa L., was performed. The reticuloendothelial system-potentiating, anti-complementary and alkaline phosphatase-inducing activities of ukonan A and its degradation products were investigated. Methylation analyses of both the primary and the secondary Smith degradation products indicated that the core structural features of ukonan A include a backbone chain mainly composed of beta-1,3-linked D-galactose, beta-1,4-linked D-xylose and alpha-1,2-linked L-rhamnose residues. All of the galactose units in the backbone carry side chains composed of alpha-L-arabino-beta-D-galactosyl or beta-D-galactosyl residues at position 6. Ukonan A has a remarkable effect on each of the three kinds of immunological activities. Periodate oxidation caused pronounced decrease or disappearance of the activities, but the controlled Smith degradation product having the core structure of polysaccharide showed considerable restoration of these activities. 相似文献
38.
Fumoto M Hinou H Ohta T Ito T Yamada K Takimoto A Kondo H Shimizu H Inazu T Nakahara Y Nishimura S 《Journal of the American Chemical Society》2005,127(33):11804-11818
The chemoselective polymer blotting method allows for rapid and efficient synthesis of glycopeptides based on a "catch and release" strategy between solid-phase and water-soluble polymer supports. We have developed a heterobifunctional linker sensitive to glutamic acid specific protease (BLase). The general procedure consists of five steps, namely (i) the solid-phase synthesis of glycopeptide containing BLase sensitive linker, (ii) subsequent deprotections and the release of the glycopeptide from the resin, (iii) chemoselective blotting of the glycopeptide intermediates in the presence of water-soluble polymers with oxylamino functional groups, (iv) sugar elongations using glycosyltransferases, and (v) the release of target glycopeptides from the polymer platform by selective BLase promoted hydrolysis. The combined use of the solid-phase chemical syntheses of peptides and the enzymatic syntheses of carbohydrates on water-soluble polymers would greatly contribute to the production of complicated glycopeptide libraries, thereby enhancing applicative research. We report here a high-throughput synthetic system for the various types of MUC1 glycopeptides exhibiting a variety of sugar moieties. It is our belief that this concept will become part of the entrenched repertoire for the synthesis of biologically important glycopeptides on the basis of glycosyltransferase reactions in automated and combinatorial syntheses. 相似文献
39.
The pinacol reaction of beta-halogenated alpha,beta-unsaturated aldehydes was promoted by titanium tetraiodide to give coupling products in good yields with high dl-selectivity. Subsequent reduction with H(2)/Pd-C gave saturated vic-diols in good yields. Heck coupling reaction enabled the displacement of halogens with vinyl groups without the loss of stereochemical integrities. [reaction: see text] 相似文献
40.
Electrophoretic mobilities, mu, and diffusion coefficients, D, of a small ion (molecular weight 579) were determined in dependence on the viscosity, eta, of aqueous buffer solutions containing ethylene glycol, or polyethylene glycol (PEG) with average molecular weights of 400, 20000, 100000 or 2000000, respectively, as additives. The values for mu and D are inversely proportional to the viscosity for the solutions with small-sized additives (ethylene glycol and PEG400), in accordance to Walden's rule. In contrast, for the longest polymers the mobilities and the diffusion coefficients approximate the values observed for pure water, and are nearly independent of the viscosity. This result agrees with the model of fractional free volume and the obstruction theory. For solutions with equal viscosity, three ranges can be differentiated for mu and D in relation to the size of the additive: for small additives, on the one hand, and the long-chained polymers, on the other hand, the values for mu and D are nearly independent of the size of the additive. In contrast, a pronounced increase of mu and D is found with increasing polymer size in the molecular weight range between 20000 and 100000. The ratio mu/D, occurring in a number of expressions for the plate height contributions, exhibits a remarkably small change over the entire polymer size and viscosity range (between 1 and 7 cP) under consideration. Consequently, the separation efficiency, expressed by the plate number, is found to be nearly constant, and is independent of viscosity. 相似文献