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71.
Saitoh F Mukaihira T Nishida H Satoh T Okano A Yumiya Y Ohkouchi M Johka R Matsusue T Shiromizu I Hosaka Y Matsumoto M Ohnishi S 《Chemical & pharmaceutical bulletin》2006,54(11):1535-1544
We have already reported unique compounds containing a N,O-spiro acetal structure as an orally active factor Xa (FXa) inhibitor. This time, we described a N,N-spiro acetal structure as an analogue of the N,O-spiro acetal structure for an orally active FXa inhibitor. The synthesis of these analogues could be achieved in a similar fashion to the N,O-spiro acetal synthesis. Consequently, FXa inhibitory activity was increased and more active compounds could be found (M58163: IC50 = 0.61 nM, M58169: IC50 = 0.58 nM). Additionally, the absolute configuration could be determined by X-ray crystallography analysis (M58169: (R)-config.). 相似文献
72.
Shin‐ichi Kondo Yasushi Sasai Shouichi Hosaka Takaaki Ishikawa Masayuki Kuzuya 《Journal of polymer science. Part A, Polymer chemistry》2004,42(17):4161-4167
We carried out the mechanolysis of polymethylmethacrylate (PMMA) at various mechanical energies and analyzed kinetically the mechanoradical concentration and molecular weight at various mechanical energies. The radical concentration gradually increased to a maximum and then gradually decreased after reaching the maximum value. It is suggested that the radical quenching reaction (disproportionation and/or recombination) progressed together with radical formation. Kinetic analysis of the mechanoradical concentration indicated that the actual amounts of mechanoradicals produced were larger than observed. It is also suggested that vast numbers of reactions take place in mechanolysis. The molecular weight decreased exponentially toward the limiting value, and the limiting molecular weight was larger with decreases in mechanical energy. It is also suggested that mechanoradical formation is inversely proportional to the change in molecular weight at any given mechanical energy. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 4161–4167, 2004 相似文献
73.
(Z)-3-Butylidene-4-hydroxyphthalide (5) was first synthesized regio- and stereoselectively from 3-methoxybenzyl alcohol (1) 相似文献
74.
Sumio Hosaka Toshimichi Shintani Atsushi Kikukawa Kenchi Itoh 《Applied Surface Science》1999,140(3-4):388-393
We study a nanometer-sized optical probe and image in a scanning near-field optical microscope (SNOM). We demonstrated the potential to observe 5-nm wide optical patterns using the SNOM. The probe profile was measured by using a knife-edge method and a modulated transfer function evaluation method. An aluminum covered and pipet-pulled fiber probe used here has two optical probes, one which has a large diameter of 350 nm and one which has a small diameter of around 10 nm. 相似文献
75.
To evaluate protein-protein interactions, a new voltammetric method was developed using a protein labeled with an electroactive compound. Concanavalin A (ConA), which is a lectin, recognizes α-mannose residues. Because the ConA was to be bound to ovalbumin (OVA), which has a high-mannose sugar chain, ConA labeled with daunomycin was prepared as the probe to monitor the binding. The binding to OVA was caused by the label modification of the ConA. As a result, the electrode response of the labeled ConA decreased as the OVA concentration increased. The electrode response of the labeled ConA was linearly over the range of 1.5 × 10−10 and 1.5 × 10−9 M OVA. The relative standard deviation of 1.5 × 10−8 M labeled ConA and 1.5 × 10−10 M OVA was 6.9% (n = 5). The labeled ConA-OVA binding could then be conveniently monitored based on the change in response. In contrast, interactions between the labeled ConA and a protein with no specific sugar chain also were investigated. Incubation scarcely influenced the peak current of the labeled ConA. When several concentrations of OVA were added to a serum, good recovery determined it. Consequently, this method could be applied to the measurement of protein-protein interactions. 相似文献
76.
We discuss the mass spectrum of doubly charmed mesons as hadronic molecules composed by D and D* meson. Considering the heavy quark symmetry and chiral symmetry, we introduce the one-boson ( ${\pi , \rho , \omega}$ ) exchange potential between D and D* meson. For all possible quantum numbers I(J P ) with isospin I, total angular momentum J( ≤ 2) and parity P, we solve the fully coupled channel Schrödinger equation. We find that in many quantum numbers the bound and resonant states composed by D or D* meson can exist near the DD, DD* and D*D* thresholds. 相似文献
77.
We study s-wave scattering of a hadron and a Nambu-Goldstone boson induced by the model-independent low energy interaction in the flavor SU(3) symmetric limit. Establishing the general structure of the interaction based on group theoretical arguments, we find that the interaction in the exotic channels are in most cases repulsive, and that for possible attractive channels the coupling strengths are weak and uniquely given independent of channel. Solving the scattering problem, we show that the attraction in the exotic channels is not strong enough to generate a bound state. 相似文献
78.
We study the role of magnetic interaction in the photoproduction of the kaon and hyperon. We find that the inclusion of a higher order diagram induced by the Wess–Zumino–Witten term has a significant contribution to the magnetic amplitude, which is compatible to the observed photon asymmetry in the forward angle region. This enables us to use the K∗ coupling constants which have been determined in a microscopic way rather than the phenomenological ones which differ largely from the microscopic ones. 相似文献
79.
Koichi Ichimiya
Nobuo Hosaka
《Experimental Thermal and Fluid Science》1992,5(6):803-807Experimental results are presented for characteristics of impingement heat transfer caused by three slot jets. Experimental values were obtained for the dimensionless distance H = 0.5−3, dimensionless pitch P = 6−16, and Reynolds number Re = 500−8000. For laminar impinging flow, they were compared with numerical results. For turbulent impinging flow, two peaks of the local Nusselt number were obtained behind the second nozzle. The position of the second peak approached the nozzle as the space between nozzle and impinged surface decreased. The average Nusselt number between the central and second nozzles was determined from the ratio P/H and the Reynolds number based on the pitch of the nozzles. 相似文献
80.
Ultrasound-enhanced membrane-cleaning processes applied water treatments: influence of sonic frequency on filtration treatments 总被引:15,自引:0,他引:15
Ultrasound (US) cleaning technique was applied to remove fouling of ultrafiltration (UF) and microfiltration (MF) membranes which were used to treat peptone and milk aqueous solutions, respectively. Membrane operations were performed by cross-flow filtration with 60 kPa operating pressure in an US field. The US employed had 28, 45 and 100 kHz frequency with 23 W/cm(2) output power. For each polymeric membrane made of polysulfone UF and cellulose MF, cleaning experiments were carried out with and without US after fouling. The fouled UF and MF membranes showed volume flux decline, but the membrane property was recovered by US irradiation. It was found in 28 kHz frequency that water cleaning was effective for recovery of declined condition due to fouling. Also, US-enhanced permeability of membranes was discussed in both membrane systems. We observed that US decreased the fouling condition in both membrane systems when US was irradiated before fouling. It was found that 28 kHz frequency US could enhance formation of the fouled layer in both filtration systems of peptone and milk solution. 相似文献