Shape optimization of coronary artery stent based on a parametric model

The implantation of intravascular stent (IVS) is a kind of coronary angioplasty to restore the blood flow perfusion to the downstream of the heart muscle tissue. The superior mechanical properties of a stent guarantee the successful implantation. This paper intends to improve the mechanical properties of MAC STENT^TM by utilizing optimization theory instead of the conventional trial-and-error approach. In order to achieve this goal, firstly, a reliable procedure of finite element analysis (FEA) is established based on a parametric geometric model. The FEA overcomes the difficulties due to nonlinearities such as elasto-plasticity, large deformation, large strains and contact. It can simulate the stent's deformations during a loading scheme of three phases without any possible failures or irregularities. Secondly, a single objective function, which includes the main mechanical properties of stents, is proposed to replace the initial multi-objective function and then an optimization model is formulated. An optimal design of MAC-J09-3.0 stent is obtained after successful execution of the optimizing process using 41 loops. Its comprehensive mechanical properties are largely improved. It is concluded that the optimization theory is very useful and efficient in the studies of coronary artery stents, although the optimization task encounters many severe difficulties and requires extensive calculation. The result also shows that the single objective function proposed in this paper is practical.     

Discovery of New Natural Products by Intact‐Cell Mass Spectrometry and LC‐SPE‐NMR: Malbranpyrroles,Novel Polyketides from Thermophilic Fungus Malbranchea sulfurea

Six photosensitive polyketides, malbranpyrroles A–F, were discovered from the thermophilic fungus Malbranchea sulfurea by using intact‐cell desorption/ionization on silicon mass (ICD‐MS) and LC‐SPE‐NMR. These two strategies facilitate the searching and structural determination of unstable natural products. The ICD‐MS indicated that only brown hyphae of M. sulfurea can produce malbranpyrroles. The biosynthetic pathway of malbranpyrroles was evidenced by ¹³C isotope precursors and amino acid feeding experiments. The cytotoxicity data revealed that the conformation of the conjugated system in malbranpyrroles does not affect cytotoxic potency against cancer cell lines. In addition, the chlorine atom was shown to be the pharmacophore for cytotoxicity.     

二维组装纳米银粒子上对巯基苯胺的表面增强拉曼光谱研究

采用表面自组装方法在聚赖氨酸修饰ITO电极表面和对巯基苯胺修饰光滑银表面组装了纳米银粒子的二维结构。FT -SERS光谱结果表明 ,巯基苯胺的吸附取向垂直于金属银表面 ,其中电磁增强机理起主导作用 ,但同时也存在化学增强的贡献。纳米银粒子的“体积效应”使其与吸附分子间的电荷转移更为有利。耦联于纳米银和光滑银表面间的巯基苯胺的拉曼散射增强则与纳米银粒子和光滑银表面的耦合而导致的局部电磁场增强直接相关。     

四元合金GaxIn1-xAs1-ySby的禁带宽度与组分关系的计

GalnAsSb是直接带隙、窄禁带的半导体材料,其波长范围为0. 87-12μm,粗盖了2-4 m, 3-5μm和8-12μm三个重要的红外应用波段,可制作室温下工作的红外光电器件,在光纤通信、环境监测、资源勘探、空间技术及军事等方面有广泛的应用前景.     

类氖钛X射线激光实验研究

在“星光”装置上采用预脉冲技术和透-反射线聚焦系统成功地进行了类氛钛x射线激光实验.测量了TiXⅢ,3s-3p,J=0～1激光线的增益系数.首次实验研究了预脉冲能量不同时,激光线强度随泵浦激光能量的变化及其发散角和偏转角.     

General Kloosterman Sums and the Difference Between an Integer and Its Inverse Modulo Q

The main purpose of this paper is to use the generalized Bernoulli numbers, Gauss sums and the mean value theorems of Dirichlet L-functions to study the asymptotic property of one class of number-theoretic functions, and to give four interesting hybrid mean value formulae.     

Stochastic Resonance in an Over-Damped Bias Linear System with Dichotomous Noise

The stochastic resonance in an over-damped bias linear system subject to multiplicative and additive dichotomous noise （DN） is investigated. By using the linear-response theory and the properties of the DN, the exact expressions are found for the signal-to-noise ratio （SNR）. It is shown that the SNR is a non-monotonic function of the correlation time of the additive DN, and it varies non-monotonically with the bias of the external field, the intensity and asymmetry of the multiplicative DN, as well as the external field frequency. Moreover, the SNR depends on the bias of the system, as well as the strength and asymmetry of the additive DN.     

氧化物表面的侧表面原子成象——Ⅰ.Eu_2O_2晶体由位错滑移形成表面台阶的动态原位观察

通过高分辨电子显微术获得了Eu_2O_3晶体分子清洁的表面侧面原子成象,观察到了由表面附近位错滑移出表面而形成表面原子台阶的动态变化过程,同时还观察到了此种表面台阶的形核生长。