Efficient synthesis of the core structure of muraymycin and caprazamycin nucleoside antibiotics based on a stereochemically revised sulfur ylide reaction

The reaction of protected uridine 5′-aldehydes with sulfur ylides has been reinvestigated. Further transformation of the resulting epoxide product provided a compound of which a single crystal for X-ray diffraction was obtained. As a consequence from the elucidated structure, the stereochemical configuration of the epoxide furnished by the sulfur ylide reaction was revised. Based on these results, an efficient synthesis of the core structure of the naturally occurring muraymycin and caprazamycin nucleoside antibiotics was developed.     

Spectro-temporal modulation subspace-spanning filter bank features for robust automatic speech recognition

In an attempt to increase the robustness of automatic speech recognition (ASR) systems, a feature extraction scheme is proposed that takes spectro-temporal modulation frequencies (MF) into account. This physiologically inspired approach uses a two-dimensional filter bank based on Gabor filters, which limits the redundant information between feature components, and also results in physically interpretable features. Robustness against extrinsic variation (different types of additive noise) and intrinsic variability (arising from changes in speaking rate, effort, and style) is quantified in a series of recognition experiments. The results are compared to reference ASR systems using Mel-frequency cepstral coefficients (MFCCs), MFCCs with cepstral mean subtraction (CMS) and RASTA-PLP features, respectively. Gabor features are shown to be more robust against extrinsic variation than the baseline systems without CMS, with relative improvements of 28% and 16% for two training conditions (using only clean training samples or a mixture of noisy and clean utterances, respectively). When used in a state-of-the-art system, improvements of 14% are observed when spectro-temporal features are concatenated with MFCCs, indicating the complementarity of those feature types. An analysis of the importance of specific MF shows that temporal MF up to 25 Hz and spectral MF up to 0.25 cycles/channel are beneficial for ASR.     

Search for charged Higgs,scalar tau's and a test of technicolor models

We have used our measurements of final states from e⁺e^? containing an isolated muon and a hadronic or electron shower to search for new spin 0 charged particles. We exclude (95% CL) a supersymmetric partner of the τ with a mass less than 14 GeV/c². We obtain upper limits on the branching ratio to τv_τ for charged Higgs particles or technipions with masses up to 14 GeV/c². This disagrees with some technicolor model predictions.     

Comparison of the temperature stresses in a free and in a constrained cylinder

The conditions under which the radial and peripheral stresses in a free and in a constrained cylinder coincide at the ends of the cylinder when the temperature distribution is axially symmetrical are considered.P. I. Baranov Central Institute for Aircraft Engine Construction, Moscow. Translated from Mekhanika Polimerov, No. 1, pp. 163–165, January–February, 1972.     

Freezing point osmometry of milk to determine the additional water content – an issue in general quality control and German food regulation

Background  

The determination of the osmolality of aqueous samples using a freezing point osmometer is a well-established, routine laboratory method. In addition to their use in clinical and pharmaceutical laboratories, freezing point osmometers are also employed in food testing laboratories. One application is the determination of the osmolality of milk. Although cow's milk is a natural product whose water content is approximately 87%, the osmolality of milk is a significant value when the milk is collected from a larger population of animals. This value is used in milk processing to control the water content, based on the German Food Control Regulations for Milk.     

Calculation of thermal stresses in an orthotropic cylinder

The present article describes the determination of thermal stresses in an orthotropic cylinder with an axially symmetric temperature field taking into account the change in the elasticity constants over the cylinder radius. A closed solution is given for constant elasticity coefficients.P. I. Baranov Central Institute of Aircraft-Engine Building, Moscow. Translated from Mekhanika Polimerov, No. 2, pp. 310–314, March–April, 1972.     

Balancing capacity and lot sizes

In many companies there is an on-going discussion about capacity, capacity utilization and capital tied up in inventories. However, traditional models such as the EOQ model only include capacity considerations in the set-up cost, or in the cost of a replenishment order. This implies e.g. that they do not consider the set-up time as a capacity constraint. Furthermore, in these models the set-up cost is usually treated as a constant, even though the opportunity cost for capacity in general is dependent upon the capacity utilization.The purpose of this paper is to derive an analytical model for the balancing of capacity and lot sizes. The model includes costs for capacity, work-in-process (queueing, set-up, and processing time), and finished goods inventory. The total costs are minimized with respect to capacity. Then, the corresponding, recommended lot sizes are determined. The model was tested with data from a Swedish manufacturing company. The results turned out to coincide with experiences of the company in many important respects. The model offers production management an opportunity to discuss the relationship between capacity, work-in-process, and lot sizes.