Robust Design of a Bimetallic Micro Thermal Sensor Using Taguchi Method

In this study, a performance optimization process for a bimetallic micro thermal sensor using the Taguchi quality engineering method is described. Sensor performance is obtained by simulating the theoretical model, which shows the effect of the beam deflection on capacitance during changes in temperature. Optimal parameter combinations are determined using Taguchi experimental design method with at least 90 % confidence level. The level of importance of the parameters on the sensor’s sensitivity is determined using the analysis of signal-to-noise ratio as well as analysis of variance. The improvement in S/N ratio is 29.47 dB, representing an increase of 29.74 times in sensitivity.     

Minimum Required Local Storages of an Automated Assembly System

An optimal strategy for selection of the required local storages of the workstations and transporter stations of a finite capacity flexible assembly line system is presented while controlling the bottleneck problem. For this purpose, a mixed non-Markovian queueing network with infinite capacity nodes is presented to model its performance, a stochastic optimization model is provided and a heuristic algorithm is developed for solving it. Finally, an example is presented and the approximation results are compared with those from a simulation study.     

Effects of final state interactions in B^ + \to D_S^ + \bar K^0 decay

We investigate the effects of final state interactions (FSI) contributions in the nonleptonic two body $B^ + \to D_S^ + \bar K^0$ decay, however the hadronic decay of $B^ + \to D_S^ + \bar K^0$ is analyzed by using “QCD factorization” (QCDF) method and final state interaction (FSI). First, the $B^ + \to D_S^ + \bar K^0$ decay is calculated via QCDF method and only the annihilation graphs exist in that method. Hence, the FSI must be seriously considered to solve the $B^ + \to D_S^ + \bar K^0$ decay and the D ⁰π⁺(D ⁰*ρ⁺), D ⁺π⁰(D ⁺*ρ⁰) and D ⁺η _c (D ⁺*J/ψ) via the exchange of K ^+(*), K ^0(*) and D _s ^+(*) mesones are chosen for the intermediate states. To estimate the intermediate states amplitudes, the QCDF method is again used. These amplitudes are used in the absorptive part of the diagrams. The experimental branching ratio of $B^ + \to D_S^ + \bar K^0$ decay is less than 8 × 10^?4 and the predicted branching ratio is 0.23 × 10^?9 in the absence of FSI effects and it becomes 6.74 × 10^?4 when FSI contributions are taken into account.     

Reconfigurable T-junction DNA Origami

DNA self-assembly allows the construction of nanometre-scale structures and devices. Structures with thousands of unique components are routinely assembled in good yield. Experimental progress has been rapid, based largely on empirical design rules. Herein, we demonstrate a DNA origami technique designed as a model system with which to explore the mechanism of assembly. The origami fold is controlled through single-stranded loops embedded in a double-stranded DNA template and is programmed by a set of double-stranded linkers that specify pairwise interactions between loop sequences. Assembly is via T-junctions formed by hybridization of single-stranded overhangs on the linkers with the loops. The sequence of loops on the template and the set of interaction rules embodied in the linkers can be reconfigured with ease. We show that a set of just two interaction rules can be used to assemble simple T-junction origami motifs and that assembly can be performed at room temperature.     

Reconfigurable T‐junction DNA Origami

DNA self‐assembly allows the construction of nanometre‐scale structures and devices. Structures with thousands of unique components are routinely assembled in good yield. Experimental progress has been rapid, based largely on empirical design rules. Herein, we demonstrate a DNA origami technique designed as a model system with which to explore the mechanism of assembly. The origami fold is controlled through single‐stranded loops embedded in a double‐stranded DNA template and is programmed by a set of double‐stranded linkers that specify pairwise interactions between loop sequences. Assembly is via T‐junctions formed by hybridization of single‐stranded overhangs on the linkers with the loops. The sequence of loops on the template and the set of interaction rules embodied in the linkers can be reconfigured with ease. We show that a set of just two interaction rules can be used to assemble simple T‐junction origami motifs and that assembly can be performed at room temperature.     

Study of the Effects of N Fertilization and Plant Density on the Essential Oil Composition and Yield of Cuminum cyminum L. Seeds by HS–SME

Headspace-solvent microextraction (HS–SME) with sample ultrasound irradiation was successfully used for the study of the influence of nitrogen fertilization and plant density on the essential oil yield and composition of cumin (Cuminum cyminum L.) seeds. The components were collected into a single microdrop of n-heptadecane and directly injected into a GC–MS injection port for analysis. A simplex method was used for fast optimization of the extraction parameters. The experiments were executed as split-plot based on randomized complete block design. Nitrogen fertilization as the main factor (in four levels) and plant density as subsidiary factor (in three levels) were applied. It was shown that the total GC peak areas of the HS–SME extract, is proportional to the essential oil yield of the cumin seeds obtained by a hydrodistillation method. Furthermore, similar trends in the concentrations of cuminaldehyde and most other volatile components were obtained by the two methods.     

Design,synthesis, biological evaluation,and docking study of new acridine-9-carboxamide linked to 1,2,3-triazole derivatives as antidiabetic agents targeting α-glucosidase

A new series of acridine-9-carboxamide-1,2,3-triazole derivatives 7a-m were designed, synthesized, and evaluated as novel α-glucosidase inhibitors. Acridine-9-carboxamide-1,2,3-triazole scaffold has been designed by combination of effective moieties from potent α-glucosidase inhibitors. Most of the synthesized compounds were more potent than standard inhibitor acarbose. Among the title compounds, the most potent compounds were compounds 7j , 7k , and 7a with IC₅₀ values of 120.2 ± 1.0, 151.1 ± 1.4, and 157.6 ± 1.6 μM, respectively (IC₅₀ value of acarbose = 750.0 ± 10.0 μM). Docking study of the most potent compounds demonstrated that these compounds formed stable complexes with α-glucosidase active site. Anti-α-amylase assay of compounds 7j , 7k , and 7a was performed and no activity was observed. in vitro cytotoxicity assay of the latter compounds revealed that these compounds were not cytotoxic toward human normal (HDF) and cancer (MCF-7) cell lines. ADME and toxicity prediction of compounds 7j , 7k , and 7a were also performed.     

Effects of Final State Interactions in Pure Annihilation Decay of B^{0}_{s}\rightarrow\pi^{0}\pi^{0}

We investigate the effects of final state interactions (FSI) contributions in the nonleptonic two body $B^{0}_{s} \rightarrow \pi^{0}\pi^{0}$ decay. The short distance interaction amplitude is calculated by using the annihilation diagrams and a tiny branching ratio is obtained, then the long distance amplitude is considered and calculated within FSI effects. For contributions of FSI, the ρ ⁰ ρ ⁰, π ⁺ π ^?(ρ ⁺ ρ ^?), K ⁺ K ^?(K ^+? K ^??) and $K^{0}\bar{K}^{0}(K^{0*}\bar{K}^{0*})$ are produced for intermediate states, in this case the π ⁰, π ^?(ρ ^?), K ^?(?) and $\bar{K}^{0(*)}$ mesons are exchanged. The absorptive part of the diagrams is directly calculated and the dispersive part of the rescattering amplitude can be obtained from the absorptive part via the dispersion relation. The imaginary and real parts of the amplitudes are summed over all intermediate states. The predicted branching ratio of $B^{0}_{s} \rightarrow \pi^{0}\pi^{0}$ is 0.69×10^?8 in the absence of FSI effects and it becomes 1.86×10^?4 when FSI contributions are taken into account, while the experimental result is less than 2.1×10^?4.