New insights into the selective inhibition of the β-carbonic anhydrases of pathogenic bacteria Burkholderia pseudomallei and Francisella tularensis: a proteochemometrics study

Molecular Diversity - Nowadays, antibiotic resistance has turned into one of the most important worldwide health problems. Biological end point of critical enzymes induced by potent inhibitors is...     

Thermal fluctuations in a hyperscaling-violation background

In this paper, we study the effect of thermal fluctuations on the thermodynamics of a black geometry with hyperscaling violation. These thermal fluctuations in the thermodynamics of this system are produced from quantum corrections of geometry describing this system. We discuss the stability of this system using specific heat and the entire Hessian matrix of the free energy. We will analyze the effects of thermal fluctuations on the stability of this system. We also analyze the effects of thermal fluctuations on the criticality of the hyperscaling-violation background.     

Estimating of CP-violation in <Emphasis Type="Italic">B</Emphasis><Superscript>0</Superscript>→ψ(2<Emphasis Type="Italic">S</Emphasis>)π<Superscript>0</Superscript> decay

I present estimates of CP-violating asymmetries in the non-leptonic charmonium two-body B⁰→ψ(2S)π⁰ decay and the same decays of B⁺→ψ(2S)π⁺ and B⁺→ψ(2S)K⁺ These estimates are based on QCD and improved QCD factorization approach making use of next-to-leading order (NLO) contributions. The CP-violating asymmetry for B⁰→ψ(2S)π⁰ decay is not available, according to the same calculations, it is expected if it can be measured in the future its value will be S_ψ(2S)π0(B⁰ → ψ(2S)π⁰)= 0.662 ± 0.197 and C_ψ(2S)π0(B⁰ → ψ(2S)π⁰)= 0.024 ± 0.007.     

Identification of structural systems with full characteristic matrices under single point excitation

The aim of “System Identification” is to determine modal and system properties of structural systems. This is while in “Damage Detection”, the identification of system characteristic matrices is as important as or even more important than the identification of frequency characteristics. Because of various constraints – i.e. difficulties in force excitation of structures due to their large size, geometry, and location – in practice only single excitation and partial measurement, at selected degrees of freedom, is possible. In this paper, a single dynamic load was applied to identify a structural system only along one of the degrees of freedom of the structure. Further, responses corresponding to a few degrees of freedom were also measured. To identify a system with this sort of restricted information, a new approach was introduced enabling identification of the structure?s parameters of mass, damping and stiffness. Taking into account the significant effect of noise reduction in improving system identification accuracy levels, a noise reduction technique was also proposed. The accuracy of the method was also assessed against noise level and location of single excitation. It was shown that as noise level increases, identification errors will also increase (less than 3.5 percent). It was further observed that applying single force at the first storey of the flexural structure would yield the lowest error levels in the identification results. Later, the method?s efficiency and precision were examined through the application of a “closed loop solution” to a six-storey flexural structure, and a four-span Pratt truss. The obtained results showed that the proposed method could act as an effective model in identification of system properties.     

Coarse homotopy groups

In this note on coarse geometry we revisit coarse homotopy. We prove that coarse homotopy indeed is an equivalence relation, and this in the most general context of abstract coarse structures. We introduce (in a geometric way) coarse homotopy groups. The main result is that the coarse homotopy groups of a cone over a compact simplicial complex coincide with the usual homotopy groups of the underlying compact simplicial complex. To prove this we develop geometric triangulation techniques for cones which we expect to be of relevance also in different contexts.     

Lead(II)-selective electrode based on phenyl disulfide.

A PVC membrane electrode for lead ions based on phenyl disulfide as the membrane carrier was developed. The electrode exhibits a good Nernstian slope of 29.3 +/- 0.7 mV/decade and a linear range of 2.0 x 10(-6)-1.0 x 10(-2) M for Pb(NO3)2. The limit of detection is 1.2 x 10(-6) M. It has a response time of 45 s and can be used for at least fifty days without any divergence in potential. The proposed membrane sensor revealed high selectivity for Pb2+ over a wide variety of other metal ions and could be used in the pH range of 3.5-6.3. The electrode was used as an indicator electrode in potentiometric titration of lead ions.     

Bispyridinesilver permanganate[Ag(C5H5N)2]MnO4: an efficient oxidizing reagent for organic substrates

Bispyridinesilver permanganate is an easily prepared crystalline relatively stable compounds, soluble in organic solvents; its uses as an oxidizing agent of organic compounds in benzene are described.     

The 13C chemical shifts of 2′-hydroxy-substituted N-benzylidene-anilines and some N,N-(o-hydroxy-benzylidene)diamines

¹³C chemical shifts of fourteen substituted 2′-hydroxy-N-benzylidene-anilines and three N,N-(o-hydroxy-benzylidene)-diamines are reported.     

Recognition of \text {PSL}(2,p) by order and some information on its character degrees where p is a prime

Let \(G\) be a finite group and \(\text {cd}(G)\) be the set of irreducible character degrees of \(G\) . In this paper we prove that if \(p\) is a prime number, then the simple group \(\text {PSL}(2,p)\) is uniquely determined by its order and some information about its character degrees. In fact we prove that if \(G\) is a finite group such that (i) \(|G|=|\text {PSL}(2,p)|\) , (ii) \(p\in \text {cd}(G)\) , (iii) \(\text {cd}(G)\) has an even integer, and (iv) there does not exist any element \(a\in \text {cd}(G)\) such that \(2p\mid a\) , then \(G\cong \text {PSL}(2,p)\) . As a consequence of our result we get that \(\text {PSL}(2,p)\) is uniquely determined by its order and the largest and the second largest character degrees.     

A Simulation-free Nonlinear Model Order-reduction Approach and Comparison Study

In this paper, a new approach to the model order reduction of nonlinear systems is presented. This approach does not need a simulation of the original system, and therefore, it is suitable for large systems. By separating the linear and nonlinear parts of the original nonlinear model, the idea is to consider the nonlinearities of the resulting system as additional inputs. Based on the linear system from the last step, a known order-reduction method can be applied to find the coefficients of the nonlinear and the linear parts of a reduced-order model. Two different methods from linear-order reduction (balancing and truncation and Eitelberg's method with some modification) are used for this purpose, and their advantages and disadvantages are discussed. For comparison with some known methods in order reduction of nonlinear systems, three other methods are discussed briefly. Finally, a technical nonlinear system is reduced, and different methods are compared.