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排序方式: 共有570条查询结果,搜索用时 203 毫秒
561.
Dash J Waller ZA Pantoş GD Balasubramanian S 《Chemistry (Weinheim an der Bergstrasse, Germany)》2011,17(16):4571-4581
Herein, we report the design, synthesis and biophysical evaluation of novel 1,2,3-triazole-linked diethynyl-pyridine amides and trisubstituted diethynyl-pyridine amides as promising G-quadruplex binding ligands. We have used a Cu(I)-catalysed azide-alkyne cycloaddition click reaction to prepare the 1,2,3-triazole-linked diethynyl-pyridine amides. The G-quadruplex DNA binding properties of the ligands have been examined by using a F?rster resonance energy transfer (FRET) melting assay and surface plasmon resonance (SPR) experiments. The investigated compounds are conformationally flexible, having free rotation around the triple bond, and exhibit enhanced G-quadruplex binding stabilisation and specificity between intramolecular promoter G-quadruplex DNA motifs compared to the first generation of diaryl-ethynyl amides (J. Am. Chem. Soc. 2008, 130, 15950-15956). The ligands show versatility in molecular recognition and promising G-quadruplex discrimination with 2-50-fold selectivity exhibited between different intramolecular promoter G-quadruplexes. Circular dichroism (CD) spectroscopic analysis suggested that at higher concentration these ligands disrupt the c-kit2 G-quadruplex structure. The studies validate the design concept of the 1,3-diethynyl-pyridine-based scaffold and demonstrate that these ligands exhibit not only significant selectivity over duplex DNA but also variation in G-quadruplex interaction properties based on small chemical changes in the scaffold, leading to unprecedented differential recognition of different DNA G-quadruplex sequences. 相似文献
562.
Dash Nitali Patra Sudhanwa Pritimita Prativa Yajnik Urjit A. 《The European Physical Journal C - Particles and Fields》2022,82(9):1-12
The European Physical Journal C - We present the EpIC Monte Carlo event generator for exclusive processes based on generalised parton distributions. EpIC utilises the PARTONS framework, which... 相似文献
563.
Laser material processing involving welding, ablation and cutting involves interaction of intense laser pulses of nanosecond
duration with a condensed phase. Such interaction involving high brightness radiative flux causes multitude of non-linear
events involving thermal phase transition at soild-liquid-gas interfaces. A theoretical perspective involving thermal dynamics
of the vaporization process and consequent non-linear multiple thermal phase transitions under the action of laser plasma
is the subject matter of the present work. The computational calculations were carried out where titanium (Ti) was treated
as a condensed medium. The solution to the partial differential equations governing the thermal dynamics and the underlying
phase transition event in the multiphase system is based on non-stationary Eulerian variables. The Mach number M depicts significant fluctuations due to thermal instabilities associated with the laser beam flux and intensity. A conclusive
amalgamation has been established which relates material surface temperature profile to laser intensity, laser flux and the
pressure in the plasma cloud.
相似文献
564.
Choi SK Olsen SL Adachi I Aihara H Aulchenko V Aushev T Aziz T Bakich AM Balagura V Bedny I Bitenc U Bondar A Bozek A Bracko M Brodzicka J Browder TE Chang P Chao Y Chen A Chen KF Chen WT Cheon BG Chistov R Choi Y Dalseno J Danilov M Dash M Eidelman S Gabyshev N Golob B Haba J Hara T Hayasaka K Hayashii H Hazumi M Heffernan D Hoshi Y Hou WS Hyun HJ Iijima T Inami K Ishikawa A Ishino H Itoh R Iwasaki M Iwasaki Y Kah DH Kang JH Katayama N Kawai H Kawasaki T Kichimi H Kim HO Kim SK Kim YJ 《Physical review letters》2008,100(14):142001
A distinct peak is observed in the pi +/- psi' invariant mass distribution near 4.43 GeV in B-->K pi +/- psi' decays. A fit using a Breit-Wigner resonance shape yields a peak mass and width of M=4433+/-4(stat)+/-2(syst) MeV and Gamma=45-13+18(stat)-13+30(syst) MeV. The product branching fraction is determined to be B(B 0-->K -/+Z+/-(4430)) x B(Z+/-(4430)-->pi+/-psi')=(4.1+/-1.0(stat)+/-1.4(syst)) x 10(-5), where Z+/-(4430) is used to denote the observed structure. The statistical significance of the observed peak is 6.5 sigma. These results are obtained from a 605 fb(-1) data sample that contains 657 x 10(6) BB pairs collected near the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric energy e+ e- collider. 相似文献
565.
Iwabuchi M Nakao M Adachi I Arinstein K Aulchenko V Aushev T Bakich AM Balagura V Barberio E Bay A Belous K Bhardwaj V Bitenc U Bozek A Bracko M Browder TE Chen A Chen WT Cheon BG Cho IS Choi Y Dalseno J Dash M Drutskoy A Eidelman S Fujikawa M Gabyshev N Ha H Haba J Hayasaka K Hazumi M Heffernan D Horii Y Hoshi Y Hou WS Hyun HJ Inami K Ishikawa A Ishino H Itoh R Iwasaki M Kah DH Kaji H Kang JH Kawai H Kawasaki T Kichimi H Kim HJ Kim HO Kim YI Kim YJ Kinoshita K Korpar S Krizan P Krokovny P 《Physical review letters》2008,101(4):041601
We report on a search for the doubly Cabibbo suppressed decay B+-->D*+pi0, based on a data sample of 657x10(6) BB pairs collected at the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider. We find no significant signal and set an upper limit of B(B+-->D*+pi0)<3.6x10(-6) at the 90% confidence level. This limit can be used to constrain the ratio between suppressed and favored B-->D*pi decay amplitudes, r<0.051, at the 90% confidence level. 相似文献
566.
Ushiroda Y Sumisawa K Taniguchi N Adachi I Aihara H Arinstein K Aushev T Bahinipati S Bakich AM Balagura V Barberio E Belous K Bitenc U Bondar A Bozek A Bracko M Browder TE Chang P Chao Y Chen A Chen WT Cheon BG Chistov R Cho IS Choi Y Dalseno J Dash M Eidelman S Epifanov D Gabyshev N Golob B Ha H Haba J Hara K Hara T Hayasaka K Hazumi M Heffernan D Hokuue T Hoshi Y Hou WS Hyun HJ Inami K Ishikawa A Ishino H Itoh R Iwasaki Y Kah DH Kang JH Kawai H Kawasaki T Kichimi H Kim YJ Kinoshita K 《Physical review letters》2008,100(2):021602
We report the first measurement of CP-violation parameters in B0-->rho0gamma decays based on a data sample of 657x10(6)BB pairs collected with the Belle detector at the KEKB asymmetric-energy e+e- collider. We obtain the time-dependent and direct CP-violating parameters, Srho0gamma=-0.83+/-0.65(stat)+/-0.18(syst) and Arho0gamma=-0.44+/-0.49(stat)+/-0.14(syst), respectively. 相似文献
567.
Nakahama Y Sumisawa K Adachi I Aihara H Aushev T Bakich AM Balagura V Barberio E Bedny I Belous K Bitenc U Bondar A Bozek A Bracko M Browder TE Chang P Chao Y Chen A Chen KF Chen WT Cheon BG Chistov R Cho IS Choi Y Dalseno J Dash M Drutskoy A Eidelman S Gabyshev N Golob B Ha H Haba J Hara K Hara T Hayasaka K Hazumi M Heffernan D Hoshi Y Hsiung YB Hyun HJ Iijima T Inami K Ishikawa A Ishino H Itoh R Iwasaki M Iwasaki Y Kah DH Kaji H Kang JH Katayama N Kawai H Kawasaki T Kichimi H Kim HJ Kim HO 《Physical review letters》2008,100(12):121601
We report a measurement of the CP-violating parameters in B;{0}-->K_{S}{0}K_{S}{0} decays based on a data sample of 657x10{6} BB[over ] pairs collected at the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric-energy e;{+}e{-} collider. In this Letter, one neutral B meson is fully reconstructed in the B;{0}-->K_{S}{0}K_{S}{0} decay mode, and the flavor of the accompanying B meson is identified by its decay products. The CP-violating parameters are measured from the asymmetry in the distributions of the proper-time interval between the two B decays: S_K_{S}{0}K_{S}{0}}=-0.38_{-0.77}{+0.69}(stat)+/-0.09(syst) and A_{K_{S}{0}K_{S}{0}}=-0.38+/-0.38(stat)+/-0.05(syst). 相似文献
568.
Pratigyan Dash Sasmita Samal Gyanendra Prasad Panda Anna Maria Piras Mamoni Dash 《Macromolecular bioscience》2023,23(11):2300211
Osteosarcoma (OS) is a malignant tumor, fatal for pediatric patients who do not respond to chemotherapy, alternative therapies and drugs can provide better outcomes. Zoledronic acid (Zol) belonging to the class of bisphosphonates (BPs) has a direct antitumor ability to prevent Ras GTPases modification and stimulate apoptosis. Despite advances in maintaining balance in skeletal events and direct anticancer properties, Zol causes cytotoxicity to normal healthy pre-osteoblast cells, hampering mineralization and differentiation. The study reports the preparation and evaluation of a nanoformulation that can diminish the existing drawbacks of native Zol. The cytotoxic effect is evaluated on bone cancer cells and healthy bone cells with three different cell lines namely, K7M2 (mouse OS cell line), SaOS2 (human OS cell line), and MC3T3E1 (healthy cell counterpart). It is observed that Zol nanoformulation is uptaken more (95%) in K7M2 whereas in MC3T3E1, the percent population internalizing nanoparticles (NPs) is 45%. Zol has a sustained release of 15% after 96 h from the NP which leads to a rescuing effect on the normal pre-osteoblast cells. In conclusion, it can be stated that Zol nanoformulation can be used as a good platform for a sustained release system with minimum side effects to normal bone cells. 相似文献
569.
Ritapa Chaudhuri Thumpati Prasanth Dr. Jyotirmayee Dash 《Angewandte Chemie (International ed. in English)》2023,62(7):e202219003
Herein, we demonstrate for the first time that noncanonical DNA can direct macrocyclization-like challenging reactions to synthesize gene modulators. The planar G-quartets present in DNA G-quadruplexes (G4s) provide a size complementary reaction platform for the bio-orthogonal macrocyclization of bifunctional azide and alkyne fragments over oligo- and polymerization. G4s immobilized on gold-coated magnetic nanoparticles have been used as target templates to enable easy identification of a selective peptidomimetic macrocycle. Structurally similar macrocycles have been synthesized to understand their functional role in the modulation of gene function. The innate fluorescence of the in situ formed macrocycle has been utilized to monitor its cellular localization using a G4 antibody and its in cell formation from the corresponding azide and alkyne fragments. The successful execution of in situ macrocyclization in vitro and in cells would open up a new dimension for target-directed therapeutic applications. 相似文献
570.