全文获取类型
收费全文 | 419篇 |
免费 | 11篇 |
国内免费 | 4篇 |
专业分类
化学 | 253篇 |
晶体学 | 2篇 |
力学 | 10篇 |
数学 | 91篇 |
物理学 | 78篇 |
出版年
2023年 | 7篇 |
2022年 | 24篇 |
2021年 | 19篇 |
2020年 | 18篇 |
2019年 | 24篇 |
2018年 | 15篇 |
2017年 | 10篇 |
2016年 | 13篇 |
2015年 | 15篇 |
2014年 | 14篇 |
2013年 | 42篇 |
2012年 | 24篇 |
2011年 | 29篇 |
2010年 | 21篇 |
2009年 | 18篇 |
2008年 | 19篇 |
2007年 | 18篇 |
2006年 | 15篇 |
2005年 | 11篇 |
2004年 | 11篇 |
2003年 | 7篇 |
2002年 | 4篇 |
2001年 | 4篇 |
2000年 | 3篇 |
1999年 | 2篇 |
1998年 | 4篇 |
1997年 | 4篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1990年 | 2篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1980年 | 4篇 |
1978年 | 1篇 |
1975年 | 1篇 |
1973年 | 1篇 |
1971年 | 1篇 |
1970年 | 3篇 |
1969年 | 3篇 |
1968年 | 2篇 |
1967年 | 2篇 |
1966年 | 1篇 |
排序方式: 共有434条查询结果,搜索用时 15 毫秒
41.
Tarfah Al-Warhi Adil Aldhahrani Fayez Althobaiti Eman Fayad Ola A. Abu Ali Sarah Albogami Ali H. Abu Almaaty Amgad I. M. Khedr Syed Nasir Abbas Bukhari Islam Zaki 《Molecules (Basel, Switzerland)》2022,27(12)
A novel series of amides based TMP moiety was designed, synthesized and evaluated for their antiproliferative as well as enzyme inhibition activity. Compounds 6a and 6b showed remarkable cytotoxic activity against HepG2 cells with IC50 values 0.65 and 0.92 μM, respectively compared with SAHA and CA-4 as reference compounds. In addition, compound 6a demonstrated good HDAC-tubulin dual inhibition activity as it showed better HDAC activity as well as anti-tubulin activity. Moreover, compound 6a exhibited G2/M phase arrest and pre-G1 apoptosis as demonstrated by cell cycle analysis and Annexin V assays. Further apoptosis studies demonstrated that compound 6a boosted the level of caspase 3/7. Caspase 3/7 activation and apoptosis induction were evidenced by decrease in mitochondrial permeability suggesting that activation of caspase 3/7 may occur via mitochondrial apoptotic pathway. 相似文献
42.
Yousaf Raffia bintay Bakar Shahzad Abu Mazhar Muhammad Mansoor Muhammad Adil Iqbal Mudassir 《Russian Journal of Applied Chemistry》2022,95(1):37-45
Russian Journal of Applied Chemistry - Owing to high stability, metal oxide-based ceramic thin films are of great interest for photocatalytic oxidation of water. Therefore, the current research is... 相似文献
43.
Cibacron Blue F3GA was immobilized on poly(hydroxyethyl methacrylate) cryogel and it was used for selective and efficient depletion of albumin from human serum. The poly(hydroxyethyl methacrylate) was selected as the basic component because of its inertness, mechanical strength, chemical and biological stability, and biocompatibility. Cibacron Blue F3GA was covalently attached to the poly(hydroxyethyl methacrylate) cryogel to produce poly(hydroxyethyl methacrylate)-Cibacron Blue F3GA cryogel affinity column. The poly(hydroxyethyl methacrylate)-Cibacron Blue F3GA cryogel was characterized with respect to gelation yield, swelling degree, total volume of macropores, Fourier Transform Infrared spectroscopy, and scanning electron microscopy. It was found that the maximum amount of adsorption (343 mg/g of dry cryogel) obtained from experimental results is very close to the calculated Langmuir adsorption capacity (345 mg/g of dry cryogel). The maximum adsorption capacity for poly(hydroxyethyl methacrylate)-Cibacron Blue F3GA cryogel column was obtained as 950 mg/g of dry cryogel for nondiluted serum. The adsorption capacity decreased with increasing dilution ratios while the depletion ratio of albumin remained as 77% in serum sample. Finally, the poly(hydroxyethyl methacrylate)-Cibacron Blue F3GA cryogel was optimized for using in the fast protein liquid chromatography system for rapid removal of the high abundant proteins from the human serum. 相似文献
44.
Adil Yaqub 《Results in Mathematics》2006,49(3-4):377-386
A well-known theorm of Jacobson asserts that a ring R with the property that for every x in R there exists an integer n(x) > 1 such that xn(x) = x is necessarily commutative. With this as motivation, we define an N0-ring to be a ring which satisfies a weaker hypothesis than the “xn(x) = x” condition in Jacobson’s Theorem. We consider commutativity of N0-rings, usually with the additional hypothesis that the ground ring is also weakly periodic-like. 相似文献
45.
Navasardyan T Adams GS Ahmidouch A Angelescu T Arrington J Asaturyan R Baker OK Benmouna N Bertoncini C Blok HP Boeglin WU Bosted PE Breuer H Christy ME Connell SH Cui Y Dalton MM Danagoulian S Day D Dodario T Dunne JA Dutta D El Khayari N Ent R Fenker HC Frolov VV Gan L Gaskell D Hafidi K Hinton W Holt RJ Horn T Huber GM Hungerford E Jiang X Jones M Joo K Kalantarians N Kelly JJ Keppel CE Kubarovski V Li Y Liang Y Malace S Markowitz P McGrath E McKee P Meekins DG Mkrtchyan H Moziak B 《Physical review letters》2007,98(2):022001
A large data set of charged-pion (pi+/-) electroproduction from both hydrogen and deuterium targets has been obtained spanning the low-energy residual-mass region. These data conclusively show the onset of the quark-hadron duality phenomenon, as predicted for high-energy hadron electroproduction. We construct several ratios from these data to exhibit the relation of this phenomenon to the high-energy factorization ansatz of electron-quark scattering and subsequent quark-->pion production mechanisms. 相似文献
46.
Dilara Saçlıgil Serap Şenel Handan Yavuz Adil Denizli 《Journal of separation science》2015,38(15):2729-2736
Immunoaffinity adsorbent for transferrin (Tf) purification was prepared by immobilizing anti‐transferrin (Anti‐Tf) antibody on magnetic monosizepoly(glycidyl methacrylate) beads, which were synthesized by dispersion polymerization technique in the presence of Fe3O4nanopowder and obtained with an average size of 2.0 μm. The magnetic poly(glycidyl methacrylate) (mPGMA) beads were characterized by Fourier transform infrared spectroscopy, swelling tests, scanning electron microscopy, electron spin resonance spectroscopy, thermogravimetric analysis and zeta sizing analysis. The density and swelling ratio of the beads were 1.08 g/cm3 and 52%, respectively. Anti‐Tf molecules were covalently coupled through epoxy groups of mPGMA. Optimum binding of anti‐Tf was 2.0 mg/g. Optimum Tf binding from aqueous Tf solutions was determined as 1.65 mg/g at pH 6.0 and initial Tf concentration of 1.0 mg/mL. There was no remarkable loss in the Tf adsorption capacity of immunoaffinity beads after five adsorption–desorption cycles. Tf adsorption from artificial plasma was also investigated and the purity of the Tf molecules was shown with gel electrophoresis studies. 相似文献
47.
Sarı MM Armutcu C Bereli N Uzun L Denizli A 《Colloids and surfaces. B, Biointerfaces》2011,84(1):140-147
Affinity adsorption technique is increasingly used for protein purification, separation and other biochemical applications. Therapeutic molecules such as antibodies, cytokines, therapeutic DNA and plasma proteins must be purified before characterization and utilization. The aim of this study was to prepare micronsized spherical polymeric beads and to investigate the extent of their human insulin adsorption capability. Monosize poly(ethylene glycol dimethacrylate-N-methacryloyl-(L)-histidine) [poly(EDMA-MAH)] beads were prepared by modified suspension copolymerization. Functional monomer (MAH) was synthesized using methacryloyl chloride and L-histidine. The beads were characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy, swelling test and elemental analysis. MAH incorporation into monosize polymeric beads, having an average size around 2-3 μm, was estimated as 55.3 μmol MAH/g bead. Equilibrium swelling ratios of poly(EDMA-MAH) and poly(EDMA) beads were 65% and 55%, respectively. Adsorption experiments were performed under different conditions (i.e., pH, temperature, protein concentration and ionic strength). It was found that adsorption characteristics are strongly depend on these conditions. Maximum insulin adsorption capacity was achieved as 24.7 mg insulin/g poly(EDMA-MAH) beads. Results were well fitted to the Langmuir isotherm model. Compared with poly(EDMA-MAH), nonspecific insulin adsorption onto poly(EDMA) beads was very low (0.61 mg insulin/g bead) and can be negligible. It was observed that insulin could be repeatedly adsorbed and desorbed (at least 10 times) without significant loss in adsorption capacity. 相似文献
48.
Bicyclams inhibit HIV replication by binding to the CXCR4 chemokine receptor, which is the main coreceptor for gp120 used by X4, T‐tropic strains of HIV for membrane fusion and cell entry. Bicyclam AMD3100 mainly interacts with the aspartic acid residues namely Asp171 and Asp262, which are located at the extracellular ends in the CXCR4 coreceptor. Incorporation of some metal ions by the macrocyclic rings of bicyclam enhances its binding affinity to the CXCR4 receptor and enhances their anti‐HIV activity because the acetate can make a strong coordination bond to the metal and one weaker hydrogen bond to nitrogen in the cyclam ring. The interaction energy (Eint) between 150 metal–bicyclam complexes and aspartic acid has been evaluated. The metal–bicyclam complexes are obtained by the incorporation of six metal ions namely Fe3+, Co3+, Ni2+, Cu2+, Zn2+, and Pd2+ in 25 well‐known bicyclams including AMD3100. In most of the cases, Fe and Co–bicyclam complexes interact best with aspartic acid. The anti‐HIV activity of metal–bicyclam complexes can be predicted on the basis of interaction energy before the synthesis of the metal–bicyclam complex. On the basis of interaction energy, the anti‐HIV activity of bicyclam complexes can be predicted in advance to their synthesis. © 2011 Wiley Periodicals, Inc. Int J Quantum Chem, 2011 相似文献
49.
Hanane El Hajaji Nadya Lachkar Katim Alaoui Yahya Cherrah Abdellah Farah Abdesslam Ennabili Brahim El Bali Mohammed Lachkar 《Arabian Journal of Chemistry》2011,4(3):321-324
We evaluated the in vitro antioxidant property and phytochemical constituents of the crude ethyl acetate and methanol extract of the three genders of carob tree barks (spontaneous male, spontaneous female, and grafted female). The scavenging activity on DPPH (1,1-diphenyl-2-picrylhydrazyl) was determined, as well as the phenolic contents (Folin–Ciocalteu method) of both the extracts. The highest antioxidant activity and the higher amounts of total phenols were shown in methanol crude bark extract for the three genders. Variety significantly affected the phenol content and the antioxidant activity, with the spontaneous male variety globally showed a higher polyphenol concentration and antioxidant activity than the grafted female and spontaneous female. 相似文献
50.
Astulla A Hirasawa Y Rahman A Kusumawati I Ekasari W Widyawaruyanti A Zaini NC Morita H 《Natural product communications》2011,6(3):323-326
Two new acyclic diterpenes, melidianolic acids A (1) and B (2), have been isolated from the bark of Aphanamixis grandifolia. Their structures were elucidated on the basis of spectroscopic and chemical methods. Melidianolic acids A (1) and B (2) showed antimalarial activity against Plasmodium falciparum 3D7 with IC50 of 6.1 and 7.3 microg/mL, respectively. 相似文献