部分相干光在大气湍流中传输的闪烁指数

实验测量了不同空间相干度的部分相干光在实际大气湍流中传输的闪烁指数。结果表明：随着入射光空间相干度的降低,闪烁随光传输距离增长而增加的趋势变得缓慢,甚至出现减小的情况。此外,与完全相干光的闪烁指数随着径向距离的增加而增加不同,部分相干光的闪烁指数沿着光斑径向距离的增加不一定增加,而有可能出现降低。相干度越低,该效应越明显。     

弱谐波情况下透射光栅衍射效率标定方法

同步辐射光源中的高次谐波会使透射光栅衍射效率标定精度变差。为了校正光源中的高次谐波对透射光栅衍射效率标定的影响,提出了一种光源存在弱谐波情况下的透射光栅衍射效率标定方法,通过使用谐波X射线的衍射效率修正基波衍射效率标定中谐波的影响,从而得到更为准确的透射光栅衍射效率。使用该标定方法在北京同步辐射光源上开展了透射光栅相对衍射效率标定工作。实验结果表明：在100~800 eV存在高次谐波能段,修正后透射光栅一级与零级的相对衍射效率与理论模拟结果吻合较好,修正后光栅二级与一级的相对衍射效率更接近理论模拟结果,但与理论模拟结果仍有较大偏差,该偏差主要来源光栅较弱的二级衍射。     

连续波多普勒引信雷电电磁脉冲辐照效应

为了研究雷电电磁脉冲场对连续波多普勒引信安全性能的影响,确定引信的能量耦合通道和效应规律,构建了引信雷电电磁脉冲辐照试验系统,并开展了该引信雷电电磁脉冲辐照效应试验。试验结果表明：受试引信最佳能量耦合姿态为引信竖直向上,弹体轴线与辐射场传播方向垂直,三角环天线平面垂直于辐射场传播方向; 主要能量耦合通道为弹体; 不同辐照波形下引信的临界干扰场强不同,在配用152 mm弹体时,1.2/50,5.4/70,0.25/100和10/350 s波形的临界干扰场强分别约为74,60,65和75 kV/m。雷电电磁脉冲对受试引信的作用机理为：辐射能量通过弹体耦合到执行电路输入端,由于感应信号脉冲宽度满足触发脉冲宽度的最低要求,从而推动引信执行电路误动作。     

Protective Effects of Ferulic Acid on Metabolic Syndrome: A Comprehensive Review

Metabolic syndrome (MetS) is a complex disease in which protein, fat, carbohydrates and other substances are metabolized in a disorderly way. Ferulic acid (FA) is a phenolic acid found in many vegetables, fruits, cereals and Chinese herbs that has a strong effect on ameliorating MetS. However, no review has summarized the mechanisms of FA in treating MetS. This review collected articles related to the effects of FA on ameliorating the common symptoms of MetS, such as diabetes, hyperlipidemia, hypertension and obesity, from different sources involving Web of Science, PubMed and Google Scholar, etc. This review summarizes the potential mechanisms of FA in improving various metabolic disorders according to the collected articles. FA ameliorates diabetes via the inhibition of the expressions of PEPCK, G6Pase and GP, the upregulation of the expressions of GK and GS, and the activation of the PI3K/Akt/GLUT4 signaling pathway. The decrease of blood pressure is related to the endothelial function of the aortas and RAAS. The improvement of the lipid spectrum is mediated via the suppression of the HMG-Co A reductase, by promoting the ACSL1 expression and by the regulation of the factors associated with lipid metabolism. Furthermore, FA inhibits obesity by upregulating the MEK/ERK pathway, the MAPK pathway and the AMPK signaling pathway and by inhibiting SREBP-1 expression. This review can be helpful for the development of FA as an appreciable agent for MetS treatment.     

气相色谱矩形离子阱质谱联用仪的设计与性能

气相色谱离子阱质谱联用仪(GC-ITMS)广泛地应用于药物分析、环境分析、农药检测和食品分析、有机化学品分析、毒品分析以及医学和生物分析等领域。离子阱质谱作为色谱的检测器,决定了色质联用仪的分析性能,包括检出限、分辨率。离子阱质量分析器从传统的双曲型3D离子阱发展到2D线性离子阱,质量歧视效应得到了极大的改善,灵敏度得到了提高。矩形离子阱作为线性离子阱,结构简单,加工和装配容易,因此应用到GCMS系统中将具有非常大的优势。介绍了矩形离子阱质谱仪的设计方案、仪器整机的性能测试、质量分辨和质量歧视效应分析,与Agilent6890组成GCMS联用仪,对实际样品进行了分析。     

乙烯-辛烯共聚物/淀粉共混体系的非等温结晶动力学

通过差示扫描量热仪(DSC)研究了乙烯-辛烯共聚物/淀粉共混体系的非等温结晶动力学,用Jeziorny和Ozawa方程描述了结晶动力学过程.共混物的结晶温度和结晶焓强烈依赖于淀粉含量和冷却速率.结果表明,随着冷却速率的增加,每个试样的结晶放热曲线均变宽,并向低温区移动.当温度一定高时,所有试样均具有较快的结晶速率. Jeniorzy方程可以较好地描述POE/淀粉共混物的非等温结晶模式,而Ozawa方程对于POE/淀粉共混体系不太适合.     

Repurposing of intestinal defensins as multi-target,dual-function amyloid inhibitors via cross-seeding

Amyloid formation and microbial infection are the two common pathological causes of neurogenerative diseases, including Alzheimer''s disease (AD), type II diabetes (T2D), and medullary thyroid carcinoma (MTC). While significant efforts have been made to develop different prevention strategies and preclinical hits for these diseases, conventional design strategies of amyloid inhibitors are mostly limited to either a single prevention mechanism (amyloid cascade vs. microbial infection) or a single amyloid protein (Aβ, hIAPP, or hCT), which has prevented the launch of any successful drug on the market. Here, we propose and demonstrate a new “anti-amyloid and anti-bacteria” strategy to repurpose two intestinal defensins, human α-defensin 6 (HD-6) and human β-defensin 1 (HBD-1), as multiple-target, dual-function, amyloid inhibitors. Both HD-6 and HBD-1 can cross-seed with three amyloid peptides, Aβ (associated with AD), hIAPP (associated with T2D), and hCT (associated with MTC), to prevent their aggregation towards amyloid fibrils from monomers and oligomers, rescue SH-SY5Y and RIN-m5F cells from amyloid-induced cytotoxicity, and retain their original antimicrobial activity against four common bacterial strains at sub-stoichiometric concentrations. Such sequence-independent anti-amyloid and anti-bacterial functions of intestinal defensins mainly stem from their cross-interactions with amyloid proteins through amyloid-like mimicry of β-sheet associations. In a broader view, this work provides a new out-of-the-box thinking to search and repurpose a huge source of antimicrobial peptides as amyloid inhibitors, allowing the blocking of the two interlinked pathological pathways and bidirectional communication between the central nervous system and intestines via the gut–brain axis associated with neurodegenerative diseases.

Amyloid formation and microbial infection are the two common pathological causes of neurogenerative diseases. Here, we proposed a new “anti-amyloid and anti-bacteria” strategy to repurpose two intestinal defensins as multiple-target, dual-function amyloid inhibitors.     

Dielectric Properties Investigation of Metal–Insulator–Metal (MIM) Capacitors

This study presents the construction and dielectric properties investigation of atomic-layer-deposition Al₂O₃/TiO₂/HfO₂ dielectric-film-based metal–insulator–metal (MIM) capacitors. The influence of the dielectric layer material and thickness on the performance of MIM capacitors are also systematically investigated. The morphology and surface roughness of dielectric films for different materials and thicknesses are analyzed via atomic force microscopy (AFM). Among them, the 25 nm Al₂O₃-based dielectric capacitor exhibits superior comprehensive electrical performance, including a high capacitance density of 7.89 fF·µm⁻², desirable breakdown voltage and leakage current of about 12 V and 1.4 × 10⁻¹⁰ A·cm⁻², and quadratic voltage coefficient of 303.6 ppm·V⁻². Simultaneously, the fabricated capacitor indicates desirable stability in terms of frequency and bias voltage (at 1 MHz), with the corresponding slight capacitance density variation of about 0.52 fF·µm⁻² and 0.25 fF·µm⁻². Furthermore, the mechanism of the variation in capacitance density and leakage current might be attributed to the Poole–Frenkel emission and charge-trapping effect of the high-k materials. All these results indicate potential applications in integrated passive devices.     

Co-Catalyzed Asymmetric Intramolecular [3+2] Cycloaddition of Yne-Alkylidenecyclopropanes and its Reaction Mechanism

Developing new transition metal-catalyzed asymmetric cycloadditions for the synthesis of five-membered carbocycles (FMCs) is a research frontier in reaction development due to the ubiquitous presence of chiral FMCs in various functional molecules. Reported here is our discovery of a highly enantioselective intramolecular [3+2] cycloaddition of yne-alkylidenecyclopropanes (yne-ACPs) to bicyclo[3.3.0]octadiene and bicyclo[4.3.0]nonadiene molecules using a cheap Co catalyst and commercially available chiral ligand (S)-Xyl-BINAP. This reaction avoids the use of precious Pd and Rh catalysts, which are usually the choices for [3+2] reactions with ACPs. The enantiomeric excess in the present reaction can be up to 92 %. Cationic cobalt(I) species was suggested by experiments as the catalytic species. DFT calculations showed that this [3+2] reaction starts with oxidative cyclometallation of alkyne and ACP, followed by ring opening of the cyclopropyl (CP) group and reductive elimination to form the cycloadduct. This mechanism is different from previous [3+2] reactions of ACPs, which usually start from CP cleavage, not from oxidative cyclization.     

A class of azocarbazole-based carboxylates: High-efficiency ionic unimolecular photobase generators for thiol-epoxy click polymerization under blue light

Two new unimolecular azocarbazole-based visible photobase generators (Ac-C-Base) with different strong bases such as 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) and 1,1,3,3-tetramethylguanidine (TMG) as the potential active species were prepared. Their structures were confirmed by ¹H NMR, ¹³C NMR, and HR-MS. According to the photolysis and EPR results, Ac-C-Base could generate free radicals and strong bases simultaneously through the photodecarboxylation mechanism under 455 nm LED irradiation. Thus they can effectively catalyze the thiol-epoxy polymerization without post exposure baking under light exposure. In addition, the Ac-C-TBD containing a stronger base shows a faster polymerization rate and higher epoxy conversion.