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101.
In this report, we develop smart surfaces for the spatial and temporal control of mammalian cell behavior. We integrate a bioactive surface strategy with a photo-electroactive surface strategy to generate dynamic ligand surface gradients for controlling cell adhesion, tissue shape morphing, and cell tissue migration. 相似文献
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Cell‐Surface Engineering by a Conjugation‐and‐Release Approach Based on the Formation and Cleavage of Oxime Linkages upon Mild Electrochemical Oxidation and Reduction 
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下载免费PDF全文 Abigail Pulsipher Debjit Dutta Wei Luo Prof. Muhammad N. Yousaf 《Angewandte Chemie (International ed. in English)》2014,53(36):9487-9492
We report a strategy to rewire cell surfaces for the dynamic control of ligand composition on cell membranes and the modulation of cell–cell interactions to generate three‐dimensional (3D) tissue structures applied to stem‐cell differentiation, cell‐surface tailoring, and tissue engineering. We tailored cell surfaces with bioorthogonal chemical groups on the basis of a liposome‐fusion and ‐delivery method to create dynamic, electroactive, and switchable cell‐tissue assemblies through chemistry involving chemoselective conjugation and release. Each step to modify the cell surface: activation, conjugation, release, and regeneration, can be monitored and modulated by noninvasive, label‐free analytical techniques. We demonstrate the utility of this methodology by the conjugation and release of small molecules to and from cell surfaces and by the generation of 3D coculture spheroids and multilayered cell tissues that can be programmed to undergo assembly and disassembly on demand. 相似文献
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Muhammad Majid Anam Farhan Muhammad Waleed Baig Muhammad Tariq Khan Yousaf Kamal Syed Shams ul Hassan Simona Bungau Ihsan-ul Haq 《Molecules (Basel, Switzerland)》2023,28(1)
The pentacyclic triterpenoids (PTs) of plant origin are reputed to restrain prostate cancer (PCa) cell proliferation. This study aims to assess 3-epifriedelinol (EFD) isolated from aerial part of Ipomoea batatas against PCa and its potential mechanism, in vitro and in vivo. Molecular docking affirms good binding affinity of the compound with target proteins exhibiting binding energy of −7.9 Kcal/mol with BAX, −8.1 Kcal/mol (BCL-2), −1.9 Kcal/mol (NF-κB) and −8.5 Kcal/mol with P53. In the MTT assay, EFD treatment (3–50 µM) showed a significant (p < 0.05 and p < 0.01) dose and time dependent drop in the proliferative graph of DU145 and PC3, and an upsurge in apoptotic cell population. EFD displayed substantial IC50 against DU145 (32.32 ± 3.72 µM) and PC3 (35.22 ± 3.47 µM). According to Western blots, EFD administration significantly enhanced the cleavage of caspases and PARP, elevated BAX and P53 and decreased BCL-2 and NF-κB expression, thereby triggering apoptosis in PCa cells. When male Sprague Dawley rats were intoxicated with Bisphenol A (BPA), an apparent increase in prostate mass (0.478 ± 0.08 g) in comparison to control (0.385 ± 0.03 g) indicates prostatitis. Multidose treatment of EFD (10 mg/kg) significantly reduced prostate size (0.404 ± 0.05 g). EFD exhibited substantial curative potential in vivo, as hematological, hormonal and histopathological parameters have been significantly improved. Reduced peroxidation (TBARS), and suppression of inflammatory markers i.e., NO, IL-6 and TNF-α, signposts substantial antiinflammatory potential of the compound. Overall, EFD has shown better binding affinity with target molecules, acceptable ADMET profile, potent antiproliferative and apoptotic nature and significant reduction in inflamed prostate mass of rats. The present study demonstrates acceptable physicochemical and pharmacokinetic properties of the compound with excellent drugable nature, hence EFD in the form of standardized formulation can be developed as primary or adjuvant therapy against PCa and toxins-induced gonadotoxicity. 相似文献
105.
Even though extended gravity theories have come up with different healthy measures of complexity for spherical and non-spherical systems, the study of complexity factors for axially symmetric bodies under the influence of strong matter-field coupling is still up for debate. The formation of complexity factors for static axially symmetric bodies is induced by the cracking of the Riemann curvature tensor in an orthogonal manner as initiated by Herrera et al. [Phys. Rev. D 99 , 044049(2019)]. We provide the continuation of this work in the gravitational theory, where that indicates the powerful matter-field coupling due to the bilateral influence of the curvature and matter tensors. We proceed our analysis by considering axial geometry confined with anisotropic fluid constituents. In this context, we compute the field equations for the system under discussion. To examine the source's energy content, two dynamical equations that correspond to independent coordinates are constructed. The curvature tensor is split into tensorial quantities to formulate the scalar functions (structure scalars), which involve the physical attributes of the source in the domain of high curvature regimes. Among all, three of the scalars 's are nominated as complexity factors, whose inclusion enhances the inhomogeneity of the propagating system. The vanishing complexity factors criteria are set out for the specific form of the cosmic model that provides the favorable setting to minimize the system's complexity and boost its stability. Furthermore, some analytical insights under various backgrounds of the matter spheroids are presented. 相似文献
106.
Erum Jabeen;Muhammad Saad Khan;Zarmeena Qazi;Kalsoom Ghani;Hafiz Muhammad Dawood;Samar Yousaf;Rabia Fatima;Azmat Ali Khan;Roha Razzaq;Muhammad Waqas; 《应用有机金属化学》2024,38(11):e7654
DNA-binding agents often exhibits dual behavior of simultaneous binding with protein associated with cancerous cell development pathways. This simultaneous protein binding if contributed to malfunctioning of pro-apoptotic proteins will reduce anticancerous potential of drugs. The elucidation of binding target for anticancerous agent can give an insight into the cancer cell apoptotic pathway. Therefore, anticancerous Zn(II) and Ni(II) complexes of 2-guanidinobenzimidazole (2GBz) were subjected to DNA-binding mode assay along with protein-binding interference assay. The stoichiometry Zn-2GBz and Ni-2GBz were determined through density functional theory (DFT) and UV–Vis spectroscopy, followed by structural verification by X-ray crystallography. The 2GBz and Ni-2GBz were found to bind with grooves of DNA while groove binding of Zn-2GBz induced unwinding of DNA through interactive pi-stacking. Binding constant revealed the M-2GBz to be a strong binder of DNA molecule with the effect of enhanced cell killing potential of M-2GBz against MCF-7 cell lines. Protein-binding assay revealed that despite of significant interaction of M-2GBz with chick serum albumin, DNA binding was not altered by simultaneous protein binding. The most potent Zn-2GBz was found to be sphingosine 1 kinase 2 (SPhK2) which can be a cause of enhanced cancer cell apoptosis with lesser normal cell apoptosis than standard fluorouracil in MCF-7 cell lines. Co-administered Zn-2GBz increased cancer cell sensitivity towards fluorouracil as potent anticancerous agent. 相似文献
107.