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11.
Gaál V Kilár F Acs B Szijjártó Z Kocsis B Kustos I 《Colloids and surfaces. B, Biointerfaces》2005,45(3-4):125-130
Implantation of artificial intraocular lenses into the eye during ophthalmic surgical procedures ensures an unliving surface on which bacterial pathogens may attach and form biofilms. Despite antibiotic treatment bacteria growing in biofilms might cause inflammation and serious complications. In this study the adhesive ability of 7 Staphylococcus aureus and 11 coagulase-negative Staphylococcus (CNS) strains to the surface of acrylic intraocular lenses had been examined by the ultrasonic method. In untreated cases adhesion of the S. aureus and CNS strains did not differ significantly. We could not demonstrate significant differences between the adhesive ability of the standard strains and the clinical isolates. In this study a single – 60 min long – antibiotic (ciprofloxacin and tobramycin) treatment had been applied, that correlate well with the single or intermittant antibiotic prophylaxis of patients. Ciprofloxacin administration was able to reduce significantly the number of attached cells on the surface of acrylic lenses both in the case of S. aureus and CNS strains. Dependence of the effect from concentration could also be demonstrated. Tobramycin treatment was able to inhibit significantly the attachment of S. aureus cells. Despite the debate on antibiotic prophylaxis we presented in our experiments that a single antibiotic administration can decrease the attachment of bacterial cells to the surface of acrylic intraocular lenses, and might be effective in the prevention of postoperative endophthalmitis, that is a rare but serious complication of ophthalmic surgery. 相似文献
12.
Thai A Skrobol C Bates PK Arisholm G Major Z Krausz F Karsch S Biegert J 《Optics letters》2010,35(20):3471-3473
We present three-dimensional simulations of optical-parametric chirped-pulse amplification stages for a few-cycle petawatt-class laser. The simulations take into account the effects of depletion, diffraction, walk-off, quantum noise, and the nonlinear refractive index (n(2)). In the absence of n(2) effects, we show these stages can generate 3.67J pulses supporting 4fs transform-limited pulse durations. Adding the nonlinear refractive index to the simulation, the energy output is reduced by ~11% and the bandwidth narrows by ~129nm, increasing the Fourier limit by ~17.5%. 相似文献
13.
Sample preparation is the critical step in analysis of residues in biological samples. The development of a ragged method is time-consuming, because a huge number of parameters must be checked. To reduce the number of experiments Taguchi's method was applied in the sample preparation of metabolites of albendazole. During the experiments 11 controllable and 7 noise factors were investigated. From the influence of controllable and noise factors on recovery and standard deviation, conditions for the sample preparation and recovery could be concluded with high accuracy and reliability. 相似文献
14.
The capability of solid porous catalysts has been studied for the destruction or modification of halogenated aromatic compounds contaminating the pyrolysis oil of recycled plastics from electronic waste. A fast and simple experimental procedure is carried out using a micropyrolyser coupled to GC-MS in such a way that catalyst microbed was placed in the sample tube of the pyrolyser. The pyrolysis products of polycarbonate blended with a frequently applied flame retardant tetrabromobisphenol A (TBBPA) and epoxy resin containing TBBPA monomer units have been analysed, and the brominated components were compared with the thermal decomposition products of TBBPA and its diallyl ether. When TBBPA vapour passes through molecular sieve 4A a slight debromination and a partial cleavage of bisphenol A into phenols occur. Over molecular sieves of larger pore size (13X and NaY zeolite) an important decrease of TBBPA amount is observed indicating effective trapping ability of these catalysts of basic character for brominated aromatic compounds. A total chemical modification of the vapour was achieved by Al-MCM-41 catalyst that split TBBPA into bromophenols. Analogous results were obtained by carrying out similar experiments on diallyl ether of TBBPA. Moreover, it was revealed that brominated bisphenol A compounds are modified essentially the same way, either evaporated or evolved from a polycarbonate blend or produced by pyrolysis from an epoxy resin. 相似文献
15.
2-Arylsulfanyl- and benzylsulfanylpyridinium N-arylimides (2), easily available from tetrazolo[1,5-b]pyridinium salts (1), participate in 1,3-dipolar cycloaddition with aryl isothiocyanates and aryl isocyanates to result in formation of fused thioxo- and oxo[1,2,4]triazolium salts (5 and 12), respectively. This transformation is interpreted as a regular 1,3-cycloaddition followed by spontaneous elimination of the aryl- or benzylsulfanyl group. Formation of these triazolium salts can be followed--under appropriate reaction conditions--by ring-opening reactions to afford some new triazolyldienes (6). Recognition of the intermediate participation of the thiolate anion along the pathway 1 --> 5 allowed elaboration of a simple procedure to 5 implying a tandem reaction sequence. 相似文献
16.
Zsuzsanna Czibulya Éva Horváth Zoltán Nagymihály László Kollár 《Supramolecular chemistry》2016,28(5-6):582-588
AbstractThe interaction of caffeic acid and a newly synthesised cavitand derivative was investigated by UV–vis and fluorescence spectroscopy in tetrahydrofuran–water matrix. The temperature dependence of the equilibrium constants was determined first, then the thermodynamic parameters were calculated using the van’t Hoff equation. Absorption measurements highlighted entropy-controlled formation of cavitand–caffeic acid complexes with 1:2 stoichiometry. It was proved by fluorescence measurements that caffeic acid dimerisation is followed by the formation of cavitand–caffeic acid complexes with 1:2 stoichiometry. It was also shown that both the caffeic acid dimerisation and the formation of 1:2 complexes are controlled by the entropy gain. PL signal is preferred to use for analytical application in this particular case. 相似文献
17.
Dr. Mihály Herczeg Dr. László Lázár Dr. Zsuzsanna Bereczky Prof. Dr. Katalin E. Kövér István Timári Prof. Dr. János Kappelmayer Prof. Dr. András Lipták Prof. Dr. Sándor Antus Dr. Anikó Borbás 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(34):10643-10652
Two pentasaccharide sulfonic acids that were related to the antithrombin‐binding domain of heparin were prepared, in which two or three primary sulfate esters were replaced by sodium‐sulfonatomethyl moieties. The sulfonic‐acid groups were formed on a monosaccharide level and the obtained carbohydrate sulfonic‐acid esters were found to be excellent donors and acceptors in the glycosylation reactions. Throughout the synthesis, the hydroxy groups to be methylated were masked in the form of acetates and the hydroxy groups to be sulfated were masked with benzyl groups. The disulfonic‐acid analogue was prepared in a [2+3] block synthesis by using a trisaccharide disulfonic acid as an acceptor and a glucuronide disaccharide as a donor. For the synthesis of the pentasaccharide trisulfonic acid, a more‐efficient approach, which involved elongation of the trisaccharide acceptor with a non‐oxidized precursor of the glucuronic acid followed by post‐glycosidation oxidation at the tetrasaccharide level and a subsequent [1+4] coupling reaction, was elaborated. In vitro evaluation of the anticoagulant activity of these new sulfonic‐acid derivatives revealed that the disulfonate analogue inhibited the blood‐coagulation‐proteinase factor Xa with outstanding efficacy; however, the introduction of the third sulfonic‐acid moiety resulted in a notable decrease in the anti‐Xa activity. The difference in the biological activity of the disulfonic‐ and trisulfonic‐acid counterparts could be explained by the different conformation of their L ‐iduronic‐acid residues. 相似文献
18.
Ildikó NagyDénes Kónya Zsuzsanna RiedlAndrás Kotschy Géza Timári András MessmerGyörgy Hajós 《Tetrahedron》2003,59(38):7485-7489
1-Methoxy-4-aryltetrazolyldienes have been subjected to oxidative degradation to yield tetrazolyl acroleins. These compounds when reacted with 1,1-dimethylhydrazine gave 1-dimethylamino-4-aryltetrazolyl-1-azadienes. Both the acroleins and the new 1-azadienes underwent ring transformation in reaction with fumaronitrile to afford pyrazolyl derivatives. 相似文献
19.
Zsuzsanna Cs. Gyarmati Pter Csoms Gbor Bernth Pauliina Valtamo Henri Kivel Karel D. Klika Kalevi Pihlaja Gyula Argay Alajos Klmn 《Journal of heterocyclic chemistry》2004,41(2):187-199
The reactions of ethyl 5‐oxotricyclo[4.3.1.13,8]undecane‐4‐carboxylate (2) with methyl‐substituted 2‐aminopyridines in polyphosphoric acid (PPA) gave two products, linearly‐condensed pyridopyrimidinones 4a‐c and 2‐pyridylcarboxamides 5a‐c , whereas the reactions with amino, hydroxy and nitro derivatives of 2‐aminopyridine furnished only linearly‐condensed pyridopyrimidinones (4g‐j). Use of a mixture of PPA and phosphorus oxychloride as solvent afforded both linearly‐ (4a‐c,e,f) and angularly‐condensed (6a–c,e,f) pyridopyrimidinones. In toluene, with p‐toluenesulfonic acid as catalyst, 2‐pyridylcarboxamides 5a‐f were obtained. In a mixture of PPA and phosphorus oxychloride at 80–120 °C, 5a‐f yielded angularly‐condensed pyridopyrimidinones 6a‐f. All the products exhibited characteristic features, as determined by NMR and electron ionization mass spectrometry and X‐ray crystallography. 相似文献
20.
Zsuzsanna Kardos-Balogh Ferenc Sóti Mária Incze Mária Kajtár Mária Kajtár-Peredy Csaba Szántay 《Tetrahedron letters》1985,26(45):5593-5596
A stable 3-acylindolenine derivative (2) has been prepared intramolecular electrophilic acylation. The reactivity of 2 has been studied. 相似文献