Numerical simulation of flow‐induced noise using LES/SAS and Lighthill's acoustic analogy

We present a finite element (FE) formulation of Lighthill's acoustic analogy for the hybrid computation of noise generated by turbulent flows. In the present approach, the flow field is computed using large eddy simulation and scale adaptive simulation turbulence models. The acoustic propagation is obtained by solving the variational formulation of Lighthill's acoustic analogy with the FE method. In order to preserve the acoustic energy, we compute the inhomogeneous part of Lighthill's wave equation by applying the FE formulation on the fine flow grid. The resulting acoustic nodal loads are then conservatively interpolated to the coarser acoustic grid. Subsequently, the radiated acoustic field can be solved in both time and frequency domains. In the latter case, an enhanced perfectly matched layer technique is employed, allowing one to truncate the computational domain in the acoustic near field, without compromising the numerical solution. Our hybrid approach is validated by comparing the numerical results of the acoustic field induced by a corotating vortex pair with the corresponding analytical solution. To demonstrate the applicability of our scheme, we present full 3D numerical results for the computed acoustic field generated by the turbulent flow around square cylinder geometries. The sound pressure levels obtained compare well with measured values. Copyright © 2009 John Wiley & Sons, Ltd.     

Structure and dynamics in poly(L-lactide) copolymer networks

Poly(L-lactide) networks (PmLA) hydrophilized with different amounts of 2-hydroxyethyl acrylate (HEA) were investigated by dielectric relaxation spectroscopy, thermally stimulated depolarization currents, and differential scanning calorimetry. The incorporation of HEA units in the PmLA network, with the aim of modulating the water sorption capacity of the system, results in a material with a complex behavior. The system consists of phase-separated microdomains richer in one or the other comonomers that constitute the network. Initially, the addition of smalls amount of HEA units in the network gives rise to a one-phase, two-component system; however, when the amount of HEA in the system increases, a new phase (HEA-rich one) is formed containing some mLA chains that modify the main relaxation mode of these domains and the local dynamics of the system. The structure of the system has been analyzed by comparing the relaxational modes in the PmLA and PHEA homonetworks with those in the copolymer networks.     

Induced and photoinduced DNA damage by quinolones: ciprofloxacin, ofloxacin and nalidixic acid determined by comet assay

Quinolones are degraded by light with loss of their antimicrobial activity, generating active species or radicals. Evidence exists that some fluoroquinolones (lomefloxacin, fleroxacin and enoxacin) induce damage to the cellular membrane and DNA cleavage by photosensitization. In this study, the genotoxic potential of the quinolones ofloxacin, nalidixic acid and ciprofloxacin (three antimicrobials frequently used in therapy) was evaluated upon irradiation with UV light by using the comet assay on cells of the Jurkat line. The results demonstrate that there are significant differences between the control groups (positive control with 50 microM H2O2, negative controls without drug and with and without irradiation) and the groups of irradiated quinolones (ofloxacin 2.76 x 10(-5) M, nalidixic acid 2.15 x 10(-4) M and ciprofloxacin 2.01 x 10(-5) M), indicating that, at the dose of irradiation employed (necessary to produce 50% photodegradation), the photodecomposition of the quinolones enhanced DNA damage. The unirradiated drugs also exhibited genotoxicity significantly different from that of the negative control.