邻-(N-芳酰基-N-甲氨基苯)-二硫化合物的合成：通过N-甲基-2-单芳基苯并噻唑啉在溶剂中的自发偶联反应和它们的血管内皮生长因子抑制活性

N-甲基-2-单芳基苯并噻唑啉 (1) 在固体状态时可以稳定地储藏在空气中。但是,它们在不同溶剂中却表现出了不同的行为。在醇溶液或二甲亚砜-水的体系中,1相对稳定;而在其它有机溶剂如：丙酮,氯仿,二氯甲烷和乙酸乙酯等溶剂中,会发生自发偶联反应生成相应的邻-(N-芳酰基-N-甲氨基苯)-二硫化合物 (2)。对这些新的化合物 (1) 和 (2) 进行了体外人乳腺癌细胞 (MDA-MB-231) 血管内皮生长因子靶点筛选,大部分化合物都表现出了抑制活性。实验结果表明这两类化合物 (1) 和 (2) 作为血管内皮生长因子抑制剂值得进行深入研究。     

二元无机物标准熵 So298的拓扑研究

为了预测二元无机物的标准熵,基于分子图的连接矩阵和离子参数gi、qi,提出了一种新的连接性指数mQ, mG及其逆指数mQ’, mG’。 qi、gi定义为：qi=(1.1+Zi1.1) /(1.7+ni), gi=(1.4+Zi) /(0.9+ri+ri-1),其中Zi 、ni和 ri分别代表离子i的电荷数、最外层主量子数和半径。从0Q, 0Q’, 1G,和1G’,利用多元线性回归分析方法和人工神经网络方法,可以构建优良的QSPR模型。对371个二元无机物,其多元线性模型及神经网络模型的相关系数、标准偏差和平均绝对偏差分别是：0.9905, 8.29 J.K-1.mol-1, 6.48 J. K-1.mol-1, 0.9960, 5.37 J.K-1.mol-1 和 3.90 J.K-1.mol-1。留一法交叉验证表明,其多元线性模型具有良好的稳定性。两个模型对187个未进入模型的二元无机物的标准熵的预测值和实验值之间的相关系数、标准偏差和平均绝对偏差分别是：0.9897, 8.64 J. K-1.mol-1, 6.84 J. K-1.mol-1, 0.9957, 5.63 J.K-1.mol-1, 和 4.18 J.K-1.mol-1。研究表明,本文方法在预测二元无机物标准熵时比文献方法更有效,两种模型均能较精确的预测二元无机物的标准熵,且神经网络模型的预测结果更精确。     

Preparation of a Novel COOH Ion Implantation Sensor and Its Application

A novel ion implantation sensor (DNA/COOH/ITO) based on DNA immobilization in COOH/ITO probe was manufactured for the first time. The surface morphologies of the electrodes were characterized by X‐ray photoelectron spectroscopy (XPS), field‐emission‐scanning electron microscopy (FSEM) and electrochemical methods. In a 0.5 mol/L PBS solution, a sensitive oxidation peak of DNA on the COOH/ITO electrode was obtained by voltammetry. The electrochemical behavior of DNA was studied. And the oxidative peak potential of DNA was +0.400 V (vs. Ag/AgCl). Its peak current was proportional to the concentration of DNA over the range of 1.0×10^?8?1.0×10^?6 mol/L with a detection limit of 5.0×10^?9 mol/L (about 0.5 ng/mL). This sensor was applied to the direct detection of DNA samples.     

Determination and dynamics of difenoconazole residues in Chinese cabbage and soil

An analytical method was developed using a solid phase extraction （SPE） cleanup and gas chromatography for detecting the residues of difenoconazole in Chinese cabbage and soil. The recovery and the relative standard deviation of this method in Chinese cabbage was 87.6-99.0%, 1.71-10.50%, respectively; in soil was 92.4-95.5%, 4.93-10.70%, respectively. Further degradation of difenoconazole residue in Chinese cabbage and soil was studied to evaluate residue behavior and environmental safety of difenoconazole. Degradation rate of difenoconazole in both Chinese cabbage and soil followed the first order kinetics with the half-lives of 6.6-7.8 and 54.2-55.0 days, respectively.     

Novel Zn（Ⅱ） ladder-like coordination polymer constructed from designed ferrocenyl ligand

Reaction of Zn（NO3）2·6H2O with 3-（4-carboxylphenylamino）-l-ferrocenyl-2-butylen-l-one （HL） and 4,4′-bipyfidine （4,4′- bipy） in methanol solution resulted in a novel ladder-like coordination polymer {[Zn2L2（μ2-L）2（4,4′-bipy）2]·MeOH}n （1）. Its crystal structure, thermal and electrochemical properties are presented.     

A new cytotoxic 2-（2-phenylethyl）chromone from Chinese eaglewood

A new compound 8-chloro-5,6,7-trihydroxy-2-（3-hydroxy-4-methoxyphenethyl）-5,6,7,8-tetralaydro-4H-chromen-4-one （1） was isolated from the Chinese eaglewood [Aquilaria sinensis （Lour.） Gilg]. Its structure was elucidated on the basis of spectral data. Compound I showed cytotoxicity against human gastric cancer cell line （SGC-7901） in vitro by MTT method with the IC50 value of 14.6 μg/mL.     

A new anthraquinone glycoside from seeds of Cassia obtusifolia

A new anthraquinone glycoside 1, along with a known anthraquinone glycoside aurantio-obmsin-6-O-β-D-glucopyranoside 2, were isolated from the seeds of Cassia obtusifolia. On the basis of spectral and chemical evidences, the structure of 1 was established as 1-demethylaurantio-obtusin-2-O-β-D-glucopyranoside. Moreover, the 13C NMR of 2 was assigned totally and correctly for the first time based on the two-dimensional NMR.     

Glucose, cellobiose, lactose and raffinose used as chiral stationary phases in HPLC

This paper presents the enantioseparation using glucose, cellobiose, lactose and raffinose as chiral selector bonded to silica gel via an arm in HPLC. Surprisingly, they also possess high enantioseparation selectivity, may be used in normal-phase and reversed- phase mode, and there is a big chiral discriminating complementary. This work indicates that oligosaccharides could soon become very attractive as a new class of chiral stationary phase for HPLC.     

Improved Electrocatalytic Activity and Stability by Single Iridium Atoms on Iron-based Layered Double Hydroxides for Oxygen Evolution

Full understanding to the origin of the catalytic performance of a supported nanocatalyst from the points of view of both the active component and support is significant for the achievement of high performance. Herein, based on a model electrocatalyst of single-iridium-atom-doped iron (Fe)-based layered double hydroxides (LDH) for oxygen evolution reaction (OER), we reveal the first completed origin of the catalytic performance of such supported nanocatalysts. Specially, besides the activity enhancement of Ir sites by LDH support, the stability of surface Fe sites is enhanced by doped Ir sites: DFT calculation shows that the Ir sites can reduce the activity and enhance the stability of the nearby Fe sites; while further finite element simulations indicate, the stability enhancement of distant Fe sites could be attributed to the much low concentration of OER reactant (hydroxyl ions, OH⁻) around them induced by the much fast consumption of OH⁻ on highly active Ir sites. These new findings about the interaction between the main active components and supports are applicable in principle to other heterogeneous nanocatalysts and provide a completed understanding to the catalytic performance of heterogeneous nanocatalysts.     

The Universal Super Cation-Conductivity in Multiple-cation Mixed Chloride Solid-State Electrolytes

As exciting candidates for next-generation energy storage, all-solid-state lithium batteries (ASSLBs) are highly dependent on advanced solid-state electrolytes (SSEs). Here, using cost-effective LaCl₃ and CeCl₃ lattice (UCl₃-type structure) as the host and further combined with a multiple-cation mixed strategy, we report a series of UCl₃-type SSEs with high room-temperature ionic conductivities over 10⁻³ S cm⁻¹ and good compatibility with high-voltage oxide cathodes. The intrinsic large-size hexagonal one-dimensional channels and highly disordered amorphous phase induced by multi-metal cation species are believed to trigger fast multiple ionic conductions of Li⁺, Na⁺, K⁺, Cu⁺, and Ag⁺. The UCl₃-type SSEs enable a stable prototype ASSLB capable of over 3000 cycles and high reversibility at −30 °C. Further exploration of the brand-new multiple-cation mixed chlorides is likely to lead to the development of advanced halide SSEs suitable for ASSLBs with high energy density.