The semirigid tridentate 8-(2-pyridinylmethylthio)quinoline ligand (Q1) is shown to form the structurally characterized transition metal complexes [Cu(Q1)Cl2] (1), [Co(Q1)(NO3)2] (2), [Cd(Q1)(NO3)2] (3), [Cd(Q1)I2] (4). [Cu(Q1)2](BF4)2·(H2O)2 (5), [Cu(Q1)2](ClO4)2·(CH3COCH3)2 (6), [Zn(Q1)2](ClO4)2(H2O)2 (7), [Cd2(Q1)2Br4] (8), [Ag2(Q1)2(ClO4)2] (9), and [Ag2(Q1)2(NO3)2] (10). Four types of structures have been observed: ML-type in complexes 1–4, in which the anions Cl−, NO3− or I− also participate in the coordination; ML2− type in complexes 5–7 without direct coordination of the anions BF4− or ClO4− and with more (Cu2+) or less (Zn2+) distorted bis-fac coordinated Q1; M2L2-type in complex 8, in which two Br− ions act as bridges between two metal ions; and M2(μ-L)2-type in complexes 9 and 10, in which the ligand bridges two anion binding and Ag–Ag bonded ions. Depending on electron configuration and size, different coordination patterns are observed with the bonds from the metal ions to Npyridyl longer or shorter than those to Nquinoline. Typically Q1 acts as a facially coordinating tridentate chelate ligand except for the compounds 9 and 10 with low-coordinate silver(I). Except for 6 and 8, the complexes exhibit distinct constraining effects against both G(+) and G(-) bacteria. Complexes 1, 3, 4, 5, 7 have considerable antifungal activities and complexes 1, 5, 7, and 10 show selective effects to restrain certain botanic bacteria. Electrochemical studies show quasi-reversible reduction behavior for the copper(II) complexes 1, 5 and 6. 相似文献
采用荧光光谱法系统研究了β-CD对o-, m, p-氨基苯甲酸同分异构体的分子识别作用,详细讨论了介质酸度对包合过程的影响,测定了它们之间形成包合物的包合常数,比较了β-CD对三者的包合能力,提出了相应的包合机理.用一维、二维核磁共振技术对包合部位进行了探讨,并结合分子力学计算以及计算机模拟技术提出了包合物的空间构型.分子力学计算得出的结果与NMR方法所得结果相吻合. 相似文献
A series of β,γ‐unsaturated ketones were isomerized to their corresponding α,β‐unsaturated ketones by the introduction of DABCO in iPrOH at room temperature. The endo‐cyclic double bond (β,γ‐position) on ketone was rearranged to exo‐cyclic double bond (α,β‐position) under the reaction conditions. 相似文献
A series of phenyl modified polydimethylsiloxane (PDMS) / polyhydrogenmethylsiloxane (PHMS) random copolymers containing both internal Si‐H and terminal SiH2 and T (MeSiO3/2) units was synthesized in one step through n‐BuLi‐catalyzed ring‐opening polymerization of cyclic comonomers and characterized by GPC, IR and 1H and 29Si NMR. Sequential microstructures of these copolymers were determined by 29Si‐NMR spectroscopy. Epoxy‐modified polysiloxanes were prepared and used as comparable standards for the assignment of the NMR spectra. A hydride‐transfer mechanism has been proposed to account for the formation of terminal Si‐H and T group. Detailed sequential analyses and chemical shifts of 29Si‐NMR for various siloxane units are reported for the first time. 相似文献
To meet growing needs for high throughput gene expression profiling, we established a new automated high throughput TaqMan RT-PCR method for quantitative mRNA expression analysis. In this method, the Allegro( trade mark ) (Zymark) system conducts all sample tracking and liquid handling steps, and ABI PRISM 7900 HT (Applied Biosystems) is used to conduct real-time determination of the C(t) value when amplification of PCR products is first detected and accumulation of inhibitory PCR products is unlikely to occur. The ABI PRISM 7900 HT Sequence Detection System features a real-time PCR instrument with 384-well-plate compatibility and robotic loading, and continuous wavelength detection, which enables the use of multiple fluorophores in a single reaction. The Allegro System offers an assembly line approach with a modular design that allows reconfiguration of the components to accommodate variations in the assay flow. In the present study, we have established and validated a new automated High Throughput (HT) TaqMan RT-PCR- based method for quantitative mRNA expression analysis. The data demonstrate that HT-Taqman PCR is a powerful tool that can be used for measuring low concentrations of mRNA, and is highly accurate, reproducible, and amenable to high throughput analysis. Results suggest that HT-TaqMan is a reliable method for the quantification of low-expression genes and a powerful tool with HT capability for target identification/validation, structure-activity relationship (SAR) study, compound selection for efficacy studies, and biomarker identification in drug discovery and development. 相似文献
Summary: An experimental method has been developed to compare the amount of monomer absorbed in freshly produced poly(propylene) with the amount of monomer absorbed in the same material after degassing. It has been found that propylene sorption in freshly produced poly(propylene) is significantly higher than the sorption in the same but degassed polymer. The difference depends on the degree of drying and is time‐dependent. This fact can be an explanation for reduced activity often observed in the transition from liquid‐ to gas‐phase polymerization.
Pressure profile during the pressure‐swing part of the experiment. 相似文献
