One‐Pot Synthesis and Characterization of Some New Types of 5,5′‐Disubstituted Bis(imidazolidine‐2,4‐diones)

The synthesis and structural elucidation of some novel 5,5′‐disubstituted spiro and nonspiro‐bis‐hydantoins are reported. The Bucherer Burge's method has been modified for the preparation of some 5,5′‐substituted bis(imidazolidine‐2,4‐dione) derivatives starting with diketones ( 1–5 ) and dialdehydes ( 6 , 7 ). In some cases, diastereoisomeric mixtures of compounds were obtained. The resulting bis‐hydantoins ( 8–11 , 13 , 14 ) have not to our knowledge been previously reported in the literature.     

Preparation of 2,5-disubstituted pyrimidines from vinamidinium salts and synthesis of novel disulfane derivatives

Novel pyrimidine derivatives were prepared from the reaction of 2-substituted 1,3-bis(dimethylamino)-trimethinium salts with thiourea or guanidine in the presence of ethyl-diisopropylamine in ethanol at reflux, and also some 5-substituted pyrimidine-2-thiols has been used for the synthesis of novel disulfane compounds. Infrared, ¹H NMR, ¹³C NMR, and mass spectral data confirm the molecular structures of the newly synthesized compounds. The ultraviolet spectral behavior of these compounds was examined in DMSO and the ƛ_max of these compounds was studied.