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901.
Qun Dang Zhibo Zhang Shuangsheng He Yaohong Liu Tongqian Chen Stephane Bogen Vinay Girijavallabhan David B. Olsen Peter T. Meinke 《Tetrahedron letters》2014
To discover novel nucleosides as potential antiviral agents, 4′-spirocyclic phosphono-nucleosides were designed to mimic the monophosphate of R-1479, a known nucleoside inhibitor of HCV NS5B. Bypassing the first kinase step to nucleoside monophosphate is viewed as advantageous since this phosphorylation is often observed as the rate-limiting transformation to the active NTP for many nucleosides. Efficient synthetic routes were developed with a triphenylphosphine–iodine cyclization reaction as the key step to form the tetrahydrofuran 4′-spirocycle. The desired 4′-spirocyclic phosphono-cytidine analogs 12a, 12b, and 16 were prepared in 11 steps. 相似文献
902.
This article discusses the effect of water fraction on the rheological properties of waxy crude oil emulsions including gel point, yield stress, viscosity, and thixotropy. The experimental results reveal that the rheological behaviors of the w/o emulsion samples all intensify with the increase of water volume fraction within 60%. Of more significance is that a correlation for w/o emulsions between yield stress and water volume fraction is put forward with an average relative error of 6.75%. In addition, some mainstream viscosity prediction models of w/o emulsions are evaluated, and Elgibaly model is the best-fit for the emulsions in this study. 相似文献
903.
Yulin He Weina Zhou Xiangcheng Wang Baoliang Bao Guojian Zhang Cheng Wang Chunmei Wang Xuemei Wang Wei Fang 《Journal of Radioanalytical and Nuclear Chemistry》2014,301(2):469-474
In this study, we synthesized and characterized N-[11C]methyl-dopamine ([11C]MDA) for cardiac sympathetic nerve imaging. [11C]MDA was synthesized by direct N-methylation of dopamine with [11C]methyl iodide and purified by semi-preparation reverse high pressure liquid chromatography (HPLC). The total synthesis time was 45 min including HPLC purification. The radiochemical yields of [11C]MDA was 20 ± 3 %, without decay correction. The radiochemical purity was >98 % and the specific activity was about 50 GBq/mmol. The biological properties of [11C]MDA were evaluated by biodistribution study in normal mice. PET imaging was performed in healthy Chinese mini-swines. Biodistribution study showed that [11C]MDA had high myocardium uptake. PET/CT imaging showed [11C]MDA had clear and symmetrical myocardium uptake, which was blocked obviously by injecting imipramine hydrochloride. [11C]MDA would be a promising candidate of radiotracer for cardiac sympathetic nervous system imaging. 相似文献
904.
Xiao-gui Feng Qian-ge He Jian-chen Wang Jing Chen 《Journal of Radioanalytical and Nuclear Chemistry》2014,299(1):509-516
90Sr is a product of nuclear fission, the radioactivity of which can be determined by liquid scintillation counting (LSC). Because the LSC spectra of 90Sr and its daughter 90Y overlap each other, the following methods are usually used: (1) measuring immediately after 90Sr/90Y separation; (2) waiting to reach radioactive equilibrium; (3) adopting the conventional 2-window approach; and (4) using the spectra deconvolution technique. The first one requires 90Sr/90Y separation and immediate measurement; the second one is time-consuming; the third one is valid only for samples with the same quench level as the calibration standard; the last one is somewhat complicated, and in some cases it is not convenient to export the experimental data to some deconvolution software. Therefore, we have developed a modified 2-window approach to rapidly determine 90Sr and 90Y in either equilibrium or disequilibrium at low quench level. The key modification of the approach is to provide an LSC spectrum of pure 90Y with the same quench level as the sample to be determined. This modification eliminates the need to conduct 90Sr/90Y separation for the sample itself, to prepare the quench curves, and to fit the LSC spectra with some deconvolution software. 相似文献
905.
Peng He Xiaolin Hou Ala Aldahan Göran Possnert 《Journal of Radioanalytical and Nuclear Chemistry》2014,299(1):249-253
Relatively large amounts of radioactive iodine 129I (T 1/2 = 15.7 Ma) have been documented in seawater such as the English Channel, the Irish Sea and the North Sea. Data on the concentration of the iodine isotopes in waters of the Celtic Sea are missing. Aiming to provide first 129I data in the Celtic Sea and compare them with levels in the other close-by seawater bodies, surface seawater samples were analyzed for the determination of 127I and 129I concentrations. The results revealed a high level of 129I in these waters and suggest strong influence by liquid discharges from La Hague and Sellafield reprocessing facilities. 127I concentrations are rather constant while the 129I/127I ratio reaches up to 2.8 × 10?8 (ranging from 10?10 to 10?8), which is 2–4 orders of magnitude higher than pre-nuclear era natural level. Transport of 129I to the Celtic Sea is difficult to depict accurately since available data are sparse. Most likely, however, that discharges originated from La Hague may have more influence on the Celtic Sea 129I concentrations than the Sellafield. Comprehensive surface water and depth profiles 129I data will be needed in the future for assessment of environmental impact in the region. 相似文献
906.
Adsorptive removal of La(III) from aqueous solutions with 8-hydroxyquinoline immobilized GMZ bentonite 总被引:1,自引:0,他引:1
Yonggui Chen Runqiu Huang Chunming Zhu Dongbei Wu Yanhong Sun Yong He Weimin Ye 《Journal of Radioanalytical and Nuclear Chemistry》2014,299(1):665-674
Due to the low permeability, high swelling capacity and good retardation properties, bentonite has been considered as the main component of buffer/backfill material for high level radioactive wastes repository all over the world. The adsorptions of metal ion were widely investigated recently. In this presentation, we provide an easy-to-use method to immobilize 8-hydroxyquinoline onto the surface of bentonite for the use of adsorption studies of La(III) from the aqueous solution. The effects of various parameters such as contact time, pH of the solution, ionic strength and metal ion concentration on the adsorption were investigated by the batch experiments. The biggest adsorption capacity is 41.7 mg/g, higher than the value reported by our previous work which is performed by the raw bentonite. Langmuir isotherm fits the experimental data well and the adsorption follows pseudo-second-order kinetic model. In summary, 8-hydroxyquinoline immobilized GMZ bentonite is an effective adsorbent for the removal of La(III) from aqueous solutions. 相似文献
907.
Han Han Ai-Zhen Xiong Chun-Yong He Qing Liu Li Yang Zheng-Tao Wang 《Analytical and bioanalytical chemistry》2014,406(6):1781-1793
The metabolic investigation of natural products is a great challenge because of unpredictable metabolic pathways, little knowledge on metabolic effects, and lack of recommended analytical methodology. Herein, a combined strategy based on ultrahigh-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UHPLC/Q-TOF-MS), nuclear magnetic resonance (NMR) spectroscopy, and electronic circular dichroism (ECD) calculation was developed and employed for the human metabolism study of gentiopicroside (GPS), a naturally hepato-protective iridoid glycoside. The whole metabolic study consisted of three major procedures. First, an improved UHPLC/Q-TOF-MS method was used to separate and detect a total of 15 GPS metabolites that were obtained from urine samples (0 to 72 h) of 12 healthy male participants after a single 50-mg oral dose of GPS. Second, a developed “MS-NMR-MS” method was applied to accurately identify molecular structures of the observed metabolites. Finally, given that the associated stereochemistry may be a crucial factor of the metabolic activation, the absolute configuration of the reactive metabolites was revealed through chemical calculations. Based on the combined use, a pair of diastereoisomers (G05 and G06) were experimentally addressed as the bioreactive metabolites of GPS, and the stereochemical determination was completed. Whereas several novel metabolic transformations, occurring via oxidation, N-heterocyclization and glucuronidation after deglycosylation, were also observed. The results indicated that GPS has to undergo in vivo metabolism-based activation to generate reactive molecules capable of processing its hepato-protective activity. Figure
Identification of metabolites of gentiopicroside using a combined strategy 相似文献
908.
Shuai Guo Ling Qiu Yanming Wang Xuzhen Qin Hui Liu Manwen He Yaping Zhang Zhili Li Xiaohong Chen 《Analytical and bioanalytical chemistry》2014,406(18):4357-4370
Changes in serum lipidome and in tissue lipidome are associated with cancer. In this study, tissue mass spectrometry imaging (MSI) and serum lipid profiling by matrix-assisted laser desorption/ionization-Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FTICR MS) were performed to investigate significantly changed lipids in both tumor (malignant thyroid cancer (MTC) and benign thyroid tumor (BTT)) tissues and sera. Y-scatterplots of variable importance in the projection (VIP) values vs. fold change values indicate that change trends in the levels of ten lipids (i.e., phosphatidylcholine (PC)(34:1), PC(36:1), PC(38:6), phosphatidic acid (PA) (36:2), PA(36:3), PA(38:3), PA(38:4), PA(38:5), PA(40:5), and sphingomyelin (SM)(34:1)) in both tissues and sera from MTC patients, BTT patients, and normal individuals are significantly associated with these three types of pathophysiological status. In order to examine their diagnostic ability, 289 serum samples from 124 MTC patients, 43 BTT patients, and 122 normal controls were randomly divided into the training set and validation set. A biomarker of PC(34:1) exhibited excellent diagnostic ability to differentiate both MTC and BTT patients from normal individuals, with an area under the receiver operating characteristic (ROC) curve value of 0.984, a sensitivity of 96.4 %, and a specificity of 92.7 %. A panel which included PA(36:3) and SM(34:1) could distinguish between MTC and BTT, with an area under receiver operating characteristic curve (AUC) of 0.961, a sensitivity of 87.8 %, and a specificity of 92.9 %. It is worth noting that a panel consisting of PC(34:1), PA(36:3), and SM(34:1) could differentiate MTC patients from both BTT patients and normal individuals, with an AUC of 0.841, a sensitivity of 86.6 %, and a specificity of 75.5 %. Figure
Comparison of tissue lipid Profiling and serum lipid profiling using MALDI-FTICR MS to select thyroid disease-specific lipids 相似文献
909.
New Conjugated Molecules with Two and Three Dithienyldiketopyrrolopyrrole (DPP) Moieties Substituted at meta Positions of Benzene toward p‐ and n‐Type Organic Photovoltaic Materials
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Chenmin Yu Dr. Chang He Yang Yang Zhengxu Cai Hewei Luo Wenqiang Li Dr. Qian Peng Dr. Guanxin Zhang Dr. Zitong Liu Prof. Deqing Zhang 《化学:亚洲杂志》2014,9(6):1570-1578
Two conjugated molecules, TADPP3 and TADPP2‐TT , are reported, in which three and two dithienyldiketopyrrolopyrrole (DPP) moieties, respectively, are substituted at the meta positions of benzene. Based on cyclic voltammetry and absorption data, TADPP3 and TADPP2‐TT possess similar HOMO and LUMO energies of about ?5.2 and ?3.4 eV, respectively. Thin films of TADPP3 and TADPP2‐TT exhibit p‐type semiconducting behavior with hole mobilities of 2.36×10?3 and 3.76×10?4 cm2 V?1 s?1 after thermal annealing. Molecules TADPP3 and TADPP2‐TT were utilized as p‐type photovoltaic materials to fabricate organic solar cells after blending with phenyl C71 butyric acid methyl ester ( PC71BM ) and phenyl C61 butyric acid methyl ester ( PC61BM ). The relatively low JSC and fill factor values can be attributed to poor film morphologies based on AFM and XRD studies. A solar cell with a thin film of TADPP3 with PC71BM in a weight ratio of 1:2 exhibits a high open‐circuit voltage (VOC) of 0.99 V and a power conversion efficiency (PCE) of 2.47 %. Interestingly, TADPP3 can also be employed as an n‐type photovoltaic material. The blended thin film of TADPP3 with P3HT in a weight ratio of 1:2 gave a high VOC of 1.11 V and a PCE of 1.08 % after thermal annealing. 相似文献
910.
Dr. Seiji Shirakawa Dr. Lijia Wang Dr. Rongjun He Dr. Satoru Arimitsu Prof. Dr. Keiji Maruoka 《化学:亚洲杂志》2014,9(6):1586-1593
Although phase‐transfer reactions catalyzed by using quaternary ammonium salts are generally believed to require base additives, we discovered that, even without any base additives, conjugate additions of 3‐substituted oxindoles to nitroolefins proceeded smoothly in the presence of lipophilic quaternary ammonium bromide under water–organic biphasic conditions. The mechanism of this novel base‐free neutral phase‐transfer reaction system is investigated and the assumed catalytic cycle is presented together with interesting effects of water and lipophilicity of the phase‐transfer catalyst. The base‐free neutral phase‐transfer reaction system can be applied to highly enantioselective conjugate addition and aldol reactions under the influence of chiral bifunctional ammonium bromides as key catalysts. The structure of the chiral ammonium enolate intermediate is discussed based on the single‐crystal X‐ray structures of relevant ammonium salts and the importance of bifunctional design of catalyst is clearly explained in the model of intermediate. 相似文献