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21.
Zhili Wang Peiping Zhu Wanxia Huang Qingxi Yuan Xiaosong Liu Kai Zhang Youli Hong Huitao Zhang Xin Ge Kun Gao Ziyu Wu 《Analytical and bioanalytical chemistry》2010,397(6):2091-2094
Differential phase-contrast (DPC) X-ray imaging has been performed in the Talbot–Lau configuration, in which the X-ray source was a combination of an absorption grating and a laboratory X-ray generator. We report here quantitative analysis of partial coherence effects on the X-ray Talbot–Lau interferometer. Based on the visibility of the self-image, the well-known geometry condition is reproduced. It is shown that effects of partial coherence are determined by the opening ratio of the source grating, and that the effects are independent of the Talbot order and the type of the phase grating, a condition quite different from those in a Talbot interferometer. A possible explanation is discussed from the point of view of the effective spatial coherence length. Taking into account the available X-ray flux and experimental fluctuations, we present the optimum opening ratio. Furthermore, we mention that our results can also be successfully used to discuss the properties of a multiline X-ray source. 相似文献
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According to the principle of double-beam interference imaging using an infrared broadband light source, a novel method based on the optical fiber low-coherence Young's interferometer for the measurement of programmable optical fiber delay line is proposed. By measuring the small length increments of delay fiber through the evaluation of the central positions of zero-order interference fringes, we successfully construct a system with a variety of important functions, such as real-time controlling, measurement and displaying. This system offers the benefit that it can be regulated precisely to generate interference stripes once again after the length of fiber segment changes. When the locations of central stripes are moved to coincide with the original markers, the determination of the corresponding fiber optical delay time becomes really simplified, as just by reading out the tinny displacement of the reference arm. Multiple groups of experimental results demonstrate the outstanding performance of the proposed system since it bears a measuring accuracy of μm and a measuring range from 1 mm to 20 cm. 相似文献
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Shuang Cai Taoguang Huo Ning Li Zhili Xiong Famei Li 《Biomedical chromatography : BMC》2009,23(7):782-786
An UPLC/MS/MS based metabonomic method was developed and applied to the elucidation of biomarker of metformin action. The plasma metabolite profiling in healthy volunteers before and after per os metformin was determined with UPLC/MS/MS and analyzed by using multivariate statistics. Significant difference in endogenous metabolite profiles was revealed before and after administration of metformin. Four biomarkers found were lysophosphatidylcholines (LPCs), and their structures were tentatively identified to be 16:0 LPC, 18:0 LPC, 18:1 LPC and 18:2 LPC according to the molecular ions information and corresponding fragments of product ion scan. Lysophosphatidylcholine in blood may be involved in metformin treatment. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
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利用气相色谱质谱(GC/MS)电子轰击方法,对6种不同年龄和不同性别的赤鳞鱼肉中的饱和、不饱和脂肪酸(经甲酯化后)进行了测定,用色谱法作了定量,共鉴定出18种脂肪酸。 相似文献
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以2,4-二氨基-6-羟甲基吡啶并[3,2-d]嘧啶为原料,与对甲酰基苯甲酰谷氨酸二乙酯发生Wittig反应构建叶酸类似物的骨架结构,还原吡啶环得到4-氨基-8,10-二碳杂四氢叶酸类似物,在N5位取代不同基团得到四个新的4-氨基-N8,N10-二碳杂四氢叶酸类化合物,经1H NMR,13C NMR和MS对化合物的结构进行了表征.初步生物活性结果表明,此类化合物对人重组胸苷酸合成酶的抑制作用与N5位取代基有关,2个化合物在0.1 μmol·L-1的浓度下对HL-60白血病细胞的抑制率达到60%以上. 相似文献
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报道了N-{4-{N-甲基-N-[2-羟基-3-(2,4-二氧代-1,2,3,4-四氢嘧啶-5-基)氨基]丙基}氨基-3-溴}苯甲酰基-L-谷氨酸二乙酯及其衍生物的简便合成方法. 分别以4-氨基苯甲酸乙酯和4-氨基苯甲酰基-L-谷氨酸二乙酯为起始物, 经甲基化、烯丙基化、溴羟基化、环氧化、开环、脱保护等反应首次合成了6个新型5-取代氨基嘧啶类化合物, 并通过1H NMR, 13C NMR 和MS对其化学结构进行了表征. 初步生物活性结果表明, 苯环侧链的L-谷氨酸酯部分是此类化合物抑制人重组二氢叶酸还原酶的必需结构. 相似文献