钼钨铌磷杂多化合物的研究（Ⅰ）：杂多酸的合成和表征

提出了分步酸化一分步加料合成[PNb_2Mo_xW_(10-x)O_(40)]~(5-)(x=0,2,4,6)系列杂多酸的方法,给出了最佳配料比和生成反应的pH值,并进行了红外、紫外、极谱、电位滴定及热稳定性研究。     

磺胺二甲嘧啶的极谱伏安行为

本文考察了磺胺二甲嘧啶在多种底液中的极谱伏安行为，发现其在ＢｒｉｔｏｎＲｏｂｉｎｓｏｎ（ＢＲ）缓冲溶液（ｐＨ２．２）中产生一个良好的还原峰，峰电位为－０．８５Ｖ（ｖｓ．ＳＣＥ），峰电流与磺胺二甲嘧啶浓度在１×１０－７３×１０－４ｍｏｌ／Ｌ范围内呈良好的线性关系，检出限为９×１０－８ｍｏｌ／Ｌ，大多数金属离子和无机阴离子不干扰测定，可望用于定量测定用多种电化学方法研究了该还原峰电流的性质，结果表明，它是具有吸附性质的不可逆还原峰     

苦味酸荧光光化学传感器在药物分析中的应用

苦味酸水浴液对固定在增塑的聚氯乙烯（ＰＶＣ）膜中的蒽有可逆荧光熄灭作用，据此研制了测定苦味酸的荧光光化学传感器。该传感器的敏感膜的最佳组成为６～８ｍｇ蒽、５０ｍｇＰｖＣ粉、１００ｍｇ邻苯二甲酸二异辛酯。测定苦味酸的浓度范围为３．０４×１０￣（－６）～６．１６×１０￣（－３）ｍｏｌ／Ｌ，重现性良好，响应时间为５～４０秒，该传感器选择性好，许多常见亲脂明离子不干扰测定，可用于药物奎宁及辛可宁的间接测定。     

Formation of nitrogen‐containing heterocycles using di(imidazole‐1‐yl)methanimine

A mild and efficient synthesis of five‐ and six‐membered nitrogen containing heterocyclic compounds, in which di(imidazole‐1‐yl)methanimine serves as a one‐carbon source, is reported.     

Carbon Nanotubes Grown on Sepiolite as Catalyst Carrier

Multi-walled carbon nanotubes were synthesized by the catalytic decomposition of acetylene at 750℃ over sepiolite powder,which was treated with aqueous cobalt nitrate. It is expected that the composite with high specific area will have high capacity of hydrogen storage.     

Identification of formylglycine in sulfatases by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

C(alpha)-Formylglycine, the catalytic amino acid residue in the active site of sulfatases, is generated by post-translational modification of a cysteine or serine residue. We describe a highly sensitive procedure for the detection of C(alpha)-formylglycine-containing peptides in tryptic digests of sulfatase proteins. The protocol is based on the formation of hydrazone derivatives of C(alpha)-formylglycine-containing peptides when using dinitrophenylhydrazine as a matrix for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS). The hydrazone derivatives desorb and ionize with high efficiency and can be detected in the sub-femtomole range. The presence of C(alpha)-formylglycine is indicated by a mass increment of 180.13 u, corresponding to the hydrazone moiety, and also by a unique C-terminal fragment ion, characteristic of sulfatases, that becomes prominent in MALDI post-source decay mass spectra of the hydrazone derivatives.     

Modular synthesis of chiral homo- and heterotrisoxazolines. Improving the enantioselectivity in the asymmetric Michael addition of indole to benzylidene malonate

A simple approach to a diverse set of chiral trisoxazolines is described. Deprotonation of bisoxazolines 2, followed by treatment of 2-chloromethyloxazolines 3, affords chiral trisoxazolines, including chiral homo- and hetero-trisoxazolines in good to high yields. These trisoxazolines are successfully applied in the asymmetric reaction of indole with benzylidene malonate, and ee's up to 93% were obtained.