一类吡唑衍生物的3D-QSAR研究

通过比较分子力场分析方法（CoMFA）和比较分子相似性指数分析方法 (CoMSIA),系统研究了30个2-烷基（烷硫基）-5-吡唑基-1,3,4-噁二唑（噻二? 颉⑷颍├嗷衔镆种扑疚瓶莶【锘钚缘娜酆隙抗剐Ч叵怠６杂? CoMFA,研究了不同移动步长对考虑静电场和立体场作用时构效关系的影响;对于 CoMSIA,研究了移动步长、场的组合、衰减因子α等参数变化对构效关系的影响, 发现当考虑立体场、疏水场、氢键受体场的贡献时能得到较好的结果。分别得到了 两种方法最为理想的3D-QSAR模型,所得三维等值线图为发现更高活性化合物提供 了有力的指导作用。     

纤维增强复合材料强度理论的研究现状与发展趋势——————``破坏分析奥运会'评估综述

复合材料强度涉及许多力学问题,计算分析复杂. 由于分析问题的角度和解决问题的方法不同, 迄今为止已经产生了许许多多不同的强度理论. 那么, 究竟这些理论的效果如何?为此,在英国的工程与自然科学研究委员会和机械工程师协会支持下, 一个堪称为复合材料``破坏分析奥运会'的评估于1991年启动并在2004年完成. 本文根据参赛理论和评比结果, 对复合材料破坏与强度理论的研究现状进行了简要综述, 并指出了今后发展所需解决的一些问题.      

Synthesis and Insecticidal Activity of Novel N‐Pyridylpyrazole Carbonyl Thioureas

A series of novel N‐pyridylpyrazole carbonyl thioureas were designed and synthesized. Their structures were characterized by melting points, ¹H NMR, IR and elemental analysis or HRMS. The bioassay tests indicated that some of these compounds exhibited moderate insecticidal activity against Mythimna separata Walker and Culex pipiens pallens. Among 17 compounds, 5n and 5p showed 100% larvicidal activity against Mythimna separata Walker at the test concentration of 100 mg/L.     

埋在土中的输液管道的耦联振动

本文对平面应变情况下,管道、流体与外土壤介质三者间的耦联振动进行了精确分析。在严格满足所有耦合边界条件的情况下,导出了系统自由振动的频率方程,并给出了各参数对最低阶固有频率影响的数值结果。当对更复杂水一管一土耦合系统进行数值解时,本文结果可作为检验其精度的一个依据。     

A hierarchical structure with improved OMP sparse representation used with face recognition

With the rapid development of the face recognition technology, more and more optical products are applied in people's real life. The recognition accuracy can be improved by increasing the number of training samples, but the colossal training samples will result in the increase of computational complexity. In recent years, sparse representation method becomes a research hot spot on face recognition. In this paper we propose an energy constrain orthogonal matching pursuit (ECOMP) algorithm for sparse representation to select the few training samples and a hierarchical structure for face recognition. We filter the training samples with ECOMP algorithm and then we compute the weights by all selected training samples. At last we find the closest recovery sample to the test sample. Simultaneously the experimental results in AR, ORL and FERET database also show that our proposed method has better recognition performance than the LRC and SRC_OMP method.     

Nonlinear Evolution of Driven Electron Plasma Oscillations in Inhomogeneous Plasmas

ＮｏｎｌｉｎｅａｒＥｖｏｌｕｔｉｏｎｏｆＤｒｉｖｅｎＥｌｅｃｔｒｏｎＰｌａｓｍａＯｓｃｉｌｌａｔｉｏｎｓｉｎＩｎｈｏｍｏｇｅｎｅｏｕｓＰｌａｓｍａｓ￥ＳＨＥＮＧＺｈｅｎｇｍｉｎｇ；ＸＵＺｈｉｚｈａｎ；ＹＵＷｅｉ；ＭＡＪｉｎｘｉｕ（ＳｈａｎｇｈａｉＩｎ...     

柠檬醛的非均相催化氢化：二氢香茅醛的制备

对含有多个可被还原的官能团化合物的催化氢化,难以找到既有高活性又具有高度选择性的催化剂。柠檬醛分子中含有两个碳碳双键和一个醛基,随氢化条件的不同可能生成下列4种产物:     

高温超导微带线滤波器的精确设计方法探讨

文中对高温超导微带线滤波器的精确设计方法进行了探讨 ,以 GSM180 0移动通信基站用高温超导带通滤波器为例进行了设计、模拟和优化。滤波器选用平行耦合型发夹式微带线结构 ,中心频率 174 7.5 MHz,通带带宽 75 MHz。模拟结果表明 :该滤波器具有良好的频响特性 ,带内波纹 <0 .1d B,反射损耗 >15 d B,基本符合设计要求     

Synthesis and Insecticidal Evaluation of Novel Anthranilic Diamides Derivatives Containing 4‐Chlorine Substituted N‐Pyridylpyrazole

To search for potent insecticides targeting at ryanodine receptors (RyRs), a series of novel anthranilic diamides analogs containing 4‐chlorine N‐pyridylpyrazole were designed and synthesized. Their insecticidal activities were evaluated and the preliminary structure‐activity relationships (SARs) were discussed. The insecticidal results showed that some of the compounds (8a—8h, 8m, 8n) exhibited good larvicidal activities against oriental armyworm at 2.5 mg·L^–1, and compound 8m possessed 60% insecticidal activity at 0.5 mg·L^–1. For diamondback moth, 8m exhibited better activity than Chlorantraniliprole at a hundred fold preference. The calcium imaging technique experiment results suggested that compound 8m could increase the intracellular [Ca²⁺]_i. With the neurons preincubated experiment, the results confirmed that the target of this series of compounds could be RyRs in the central larvae neurons of oriental armyworm. The results indicated that compound 8m could respond as a potential modulator of the insect ryanodine receptor.