Boron doping and structure control of carbon materials for supercapacitor application: the effect of freeze-drying and air-drying for porosity engineering

Journal of Solid State Electrochemistry - In the present work, we demonstrate a strategy of combining boron doping and porosity engineering for a highly modulated carbon component and pore...     

Landweber iterative method for identifying the initial value problem of the time-space fractional diffusion-wave equation

Numerical Algorithms - This paper considers the inverse problem for identifying the initial value problem of a space-time fractional diffusion wave equation. In general, this problem is ill-posed...     

A derivative-free conjugate residual method using secant condition for general large-scale nonlinear equations

Numerical Algorithms - A fully derivative-free conjugate residual method, using secant condition, is introduced to solve general large-scale nonlinear equations. Under some conditions, global and...     

$$M_2$$M2-ranks of overpartitions modulo 6 and 10

The Ramanujan Journal - In this paper, we obtain inequalities on $$M_2$$-ranks of overpartitions modulo 6. Let $$overline{N}_2(s,m,n)$$ be the number of overpartitions of n whose $$M_2$$-rank is...     

Yellow-to-transmissive electrochromic poly(dibenzothiophene/dibenzofuran-bithiophene)

Journal of Solid State Electrochemistry - Electrochromic technologies require electrochromic π-conjugated polymers to reversibly transition between highly transmissive and broadly absorbing...     

An Activatable Lanthanide Luminescent Probe for Time‐Gated Detection of Nitroreductase in Live Bacteria

Herein we report the development of a turn‐on lanthanide luminescent probe for time‐gated detection of nitroreductases (NTRs) in live bacteria. The probe is activated through NTR‐induced formation of the sensitizing carbostyril antenna and resulting energy transfer to the lanthanide center. This novel NTR‐responsive trigger is virtually non‐fluorescent in its inactivated form and features a large signal increase upon activation. We show that the probe is capable of selectively sensing NTR in lysates as well as in live bacteria of the ESKAPE family which are clinically highly relevant multiresistant pathogens responsible for the majority of hospital infections. The results suggest that our probe could be used to develop diagnostic tools for bacterial infections.     

Preparing molecularly imprinted nanoparticles of saponins via cooperative imprinting strategy

Saponin is an important class of natural products with various pharmacological activities. The selective separation of saponins is an essential step before further analysis. Molecular imprinting has been an effective strategy for preparing antibody mimics. However, a facile and efficient imprinting strategy for saponins is still lacking owing to their amphiphilic nature. Herein, we have prepared the saponins imprinted nanoparticles via cooperative imprinting strategy. This new strategy relies on the combination of various non‐covalent interactions (hydrophobic and hydrogen bonding) and covalent boronate affinity interactions. The obtained imprinted nanoparticles could rebind specific saponins from complex matrices with good selectivity, superb tolerance to interference, and fast binding equilibrium. This method was verified to be versatile and facile. Thus, this strategy could greatly facilitate the preparation of imprinted nanoparticles for the specific recognition of saponins.     

Affibody‐Conjugated RALA Polymers Delivering Oligomeric 5‐Fluorodeoxyuridine for Targeted Therapy of HER2 Overexpressing Gastric Cancer

Affibody‐conjugated RALA (affi‐RA) are designed for delivering oligomeric 5‐fluorodeoxyuridine (FUdR, metabolite of 5‐FU) strand to raise the selectivity of 5‐fluorouracil (5‐FU), decrease its toxicity and improve its suboptimal therapeutic efficacy. The nanodrugs, FUdR@affi‐RA, are spontaneously assembled by electrostatic interaction between positively charged affi‐RA and negatively charged FUdR₁₅‐strands (15 consecutive FUdR). FUdR@affi‐RA exhibits excellent stability under simulated physiological conditions. Compared with free FUdR, FUdR@affi‐RA shows excellent targeting and higher cytotoxicity in human epidermal growth factor receptor 2 (HER2) overexpressing gastric cancer N87 cells. Moreover, the anticancer mechanism studies reveal that FUdR@affi‐RA enhances the expression and activity of apoptosis‐associated proteins in the Bcl‐2/Bax‐caspase 8,9‐caspase 3 apoptotic pathway induced by FUdR. This study indicates that the fusion vector, affi‐RA, presents a promising delivery system platform for nucleoside analogue drugs and provides a new strategy for the development of therapeutics of cancer treatment.