钇与2-(4′-氯-2′-膦酰基一苯偶氮)-7-(2′,6′-二溴-4′-氯-一苯偶氮)-1,8-二羟基-3,6-萘二磺酸配位反应动力学研究和机理探讨

用停流分光光度法获得反应的经验速率方程为R=k[y(H_2O~n)~(3+)]·[H_6R]·[H~+]~(-1)。参考Eigen-Tamm机理和测得的动力学参数,拟出了反应的可能机理。     

Indium-mediated Facile Synthesis of （6-Chloropyridine-3-yl）methyl Heterocyclic Thioether Derivatives in Aqueous Media

A series of substituted (6-chloropyridine-3-yl)methyl heterocyclic thioether derivatives were prepared by indium mediating in water. The preliminary biological tests showed that compound 3d exhibited good antiviral activity.     

Controlled/“Living “Radical Polymerization of(-)-Menthyl Methacrylate

The atom transfer radical polymerization(ARP)of (-)-menthyl methacrylatc((-)-MnMA) mediated by CuCl/bipyridine and ethy1 2-bromopropionate or 1-phenylethyl bromide in THF system has been studied.The dependence of the specific rotation on molecular weight and the CD of Poly((-)-MnMA) thus obatined was investigated.     

Stereoselective Synthesis of (+)-Avarol, (+)-Avarone, and Some Nonracemic Analogues

Synthesis of the rearranged drimane sesquiterpenoids (+)-avarol and (+)-avarone from Wieland-Miescher ketone is described. This synthetic sequence provides convenient access to the natural enantiomers and, based on comparison of the optical rotation of synthetic avarol dimethyl ether with literature data, affords material of significantly higher optical rotation than a natural source. Similar synthetic strategies have been used to obtain several related compounds, including a decalin bearing an exocyclic olefin and a highly substituted cyclohexane, that can be viewed as hybrids of the trans-fused avarol and cis-fused arenarol skeletons.     

Novel design of a pentacyclic scaffold as structural mimic of saframycin A

The design, synthesis and evaluation of a pentacyclic scaffold, CWO-324 to mimic saframycin A is described. CWO-324 is readily synthesized in five steps from 1,4-diacetyl-piperazine-2,5-dione and 2,5-dimethoxybenzaldehyde. CWO-324 was found to scission DNA, binds to bases 69-83(5′-GCAGTCAGG CACCGT-3′) of Hind III/Rsa I from plasmid pBR322 DNA in a foot-printing study and possesses anti-tumor activity.     

The Tolman length: is it positive or negative?

By means of a large-scale molecular dynamics simulation, we show that the Tolman length, although positive, is much smaller in magnitude than previously reported. We found that the range of interparticle interaction can significantly affect the magnitude of the Tolman length. When the range of interaction is longer than five molecular diameters, the Tolman length is on the order of a few hundredths of the molecular diameter, rather than a few tenths known previously.     

Investigations in the field of vinyl ethers and esters of the furan series

Vinyl-furancarboxylate has been synthesized by the reaction of-furancarboxylic acid with acetylene and with vinyl acetate in the presence of various catalysts. The structure of the vinyl ester has been confirmed by IR spectra and by catalytic hydrogenation. The acid and alkaline hydrolyses of vinyl-furancarboxylate have been studied.     

新型有机锗倍半氧化物及硫化物的合成

已先后合成的倍半氧化物类及倍半硫化物类化合物的前体,即有机锗三氯化物中只含1个锗原子。为了考查从含2个锗原子的前体合成的有机锗倍半氧化物及硫化物的药物活性,我们合成了1类化合物及相应的倍半氧化物(2类)及倍半硫化物(3类),并合成了酰基苯胺化合物1_e、2_e及3_e。结果见表1。     

KF/Al~2O~3/PEG 4000(FAP)存在下氯仿的Michael加成反应

在KF/Al~2O~3/PEG4000(FAP)存在下,氯仿可与α,β-不饱和羰基化合物进行Michael加成反应,得到中等产率的三氯甲基化合物。     

Bis{2-[dimethylamino)methyl]phenyl}silverlithium,a tetranuclear organometallic compound with bridging aryl groups between silver and lithium

Bis{2-[(dimethylamino)methyl]phenyl}silverlithium has been prepared and characterized. Molecular weight determinations, and ¹³C NMR and ¹H NMR spectra reveal that the compound exists (in benzene) as a tetranuclear mixed metal cluster containing aryl groups bridging the silver and lithium atoms. Silver-proton, silver-carbon and lithium-carbon couplings have been observed in the NMR spectra of this compound.