SHEAR BEAM MODEL FOR INTERFACE FAILURE UNDER ANTIPLANE SHEAR (Ⅱ)- INSTABILITY

Based on the (Ⅰ) of the present work, the behavior of shear beam model at crack initiation stage and at instable propagation stage was studied. The prime results include: 1) discriminant equation which clarifies the mode of instability, snap-back or snap-through, was established; 2) analytical solution was given out for the double shear beam and the load-displacement diagram for monotonic loading was presented for a full process; and 3) the problem of the energy release induced by instability was discussed.     

求解层间界面反平面剪切破坏的剪切梁模型(Ⅱ)——失稳特性

在研究(Ⅰ)的基础上,研究了剪切梁模型在裂纹萌生和失稳扩展阶段的行为特性,1)给出了软化失稳(snap-through)和回折失稳(snap-back)两种失稳行为发生的条件.2)对剪切梁在反平面剪切载荷及侧压力共同作用下的力学行为作了解析分析计算,给出了结构的位移—载荷全过程曲线.3)讨论了失稳过程中的能量释放问题,并给出了回折失稳过程中结构对外界的能量释放的计算式.     

On the differentiability of the solutions of translation equation

Aequationes mathematicae - We consider the differentiability of the solution $${F:I\times }{{\mathbb {R}}}\rightarrow I$$ of the translation equation, where I is an interval. The stability of this...     

Transplant-insert-constrain-relax-assemble (TICRA): protein-ligand complex structure modeling and application to kinases

We introduce TICRA (transplant-insert-constrain-relax-assemble), a method for modeling the structure of unknown protein-ligand complexes using the X-ray crystal structures of homologous proteins and ligands with known activity. We present results from modeling the structures of protein kinase-inhibitor complexes using p38 and Lck as examples. These examples show that the TICRA method may be used prospectively to create and refine models for protein kinase-inhibitor complexes with an overall backbone rmsd of less than 0.75 ? for the kinase domain, when compared to published X-ray crystal structures. Further refinement of the models of the kinase domains of p38 and Lck in complex with their cognate ligands from the published crystal structures was able to improve the rmsd's of the model complexes to below 0.5 ?. Our results show that TICRA is a useful approach to the problem of structure-based drug design in cases where little structural information is available for the target proteins and the binding mode of active compounds is unknown.     

Inhibition of inflammatory mediators by neobavaisoflavone in activated RAW264.7 macrophages

Flavonoids and coumarins are the major bioactive constituents identified in Psoralea corylifolia. The active fraction isolated from fruits, seeds and roots possesses antibacterial, antioxidative and immunomodulatory properties. Neobavaisoflavone is one of the flavonoids found in Psoralea corylifolia. In the present study we investigated in vitro the anti-inflammatory activity of neobavaisoflavone. Macrophages play an important role in inflammation through the release of inflammatory mediators involved in the immune response. Inappropriate and prolonged macrophage activation is largely responsible for the pathology of acute and chronic inflammatory conditions. Neobavaisoflavone significantly inhibited the production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and cytokines: IL-1β, IL-6, IL-12p40, IL-12p70, TNF-α in LPS+IFN-γ- or PMA- stimulated RAW264.7 macrophages.     

Do there exist complete sets for promise classes?

In this paper we investigate the following two questions:

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Minimum wetting rate for a decelerating liquid film

The paper presents an analytical study of a laminar decelerating liquid film falling along a vertical plate. Approximate solutions are obtained for the boundary layer within the film, film thickness, entrance length, and minimum wetting rate. It is shown that the analysis may be extended also to a film flowing over a horizontal cylinder. The theory is in reasonable agreement with the parametric trends observed in experiments on horizontal cylinders.     

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