Proton decay and horizontal symmetry

Proton decay can teach us about the so-called horizontal or family symmetry.     

Families,the invisible axion,and domain walls

We consider models in which the unbroken discrete subgroup of a Peccei-Quinn symmetry may be effectively embedded in the rest of the continuous symmetry group to avoid the formation of domain walls. In this context we may gain insight into the family question. We note that instantons in an unbroken “hypercolor” group might be used to reduce the size of the discrete symmetry or to eliminate it altogether.     

Reaction of 1-Methylindole with Dimethyl-Acetylenedicarboxylate an 2:1 Adduct-Dimethyl α, α-Bis(1-Methylindol-3-YL)-Succinate

The structure of 2:1 adduct of 1-methylindole and dimethyl acetylenedicar-boxylate was elucidated as dimethyl α, α-bis(1-methylindol-3-yl)-succinate. Some of its derivatives were prepared.     

Orientation dependence of surface critical phenomena in antiferromagnets: exact results in two dimensions

For an Ising antiferromagnet, we analyze exact expressions for the one- and two-point correlation functions for spins on the edge of a square lattice with a magnetic field applied to the surface sites. Two different edge orientations, with respect to the crystal axes, are treated. At bulk criticality, we confirm that the surface universality class depends on the edge orientation and show the importance of having the bulk phase in a pure state. For the two-point function, we find a singularity in the correlation length due to depinning effects which we argue is also present in higher dimensions.     

A new cyanogenic glycoside from Sorbaria sorbifolia var. stellipila

A new cyanogenic glycoside, sutherlandin-5-trans-p-coumarate was isolated along with a known cardiosdiospermin-5-(4-hydroxy) benzoate fr the aerial parts of Sorbaria sorbifolia (L.) A. Br. var. stellipila MAX. (Rosaceae). The structure of the new compound was established based on spectral evidence.     

Chip-LC-MS for label-free profiling of human serum

The discovery of biomarkers in easily accessible body fluids such as serum is one of the most challenging topics in proteomics requiring highly efficient separation and detection methodologies. Here, we present the application of a microfluidics-based LC-MS system (chip-LC-MS) to the label-free profiling of immunodepleted, trypsin-digested serum in comparison to conventional capillary LC-MS (cap-LC-MS). Both systems proved to have a repeatability of approximately 20% RSD for peak area, all sample preparation steps included, while repeatability of the LC-MS part by itself was less than 10% RSD for the chip-LC-MS system. Importantly, the chip-LC-MS system had a two times higher resolution in the LC dimension and resulted in a lower average charge state of the tryptic peptide ions generated in the ESI interface when compared to cap-LC-MS while requiring approximately 30 times less (~5 pmol) sample. In order to characterize both systems for their capability to find discriminating peptides in trypsin-digested serum samples, five out of ten individually prepared, identical sera were spiked with horse heart cytochrome c. A comprehensive data processing methodology was applied including 2-D smoothing, resolution reduction, peak picking, time alignment, and matching of the individual peak lists to create an aligned peak matrix amenable for statistical analysis. Statistical analysis by supervised classification and variable selection showed that both LC-MS systems could discriminate the two sample groups. However, the chip-LC-MS system allowed to assign 55% of the overall signal to selected peaks against 32% for the cap-LC-MS system.     

Coumarin-Cu(II) ensemble-based cyanide sensing chemodosimeter

An "ensemble"-based chemodosimeter 1-Cu(II) for cyanide detection is reported. 1-Cu(II) can recognize a cyanide ion over other anionic species to show a marked fluorescence enhancement under aqueous conditions. "Off-on" fluorescence change of 1-Cu(II) is proceeded by addition of cyanide, which induces decomplexation of the Cu(II) ion from nonfluorescent 1 followed by hydrolytic cleavage of the resulted Schiff base to give a strongly fluorescent coumarinaldehyde (2). The selective detection of cyanide with 1-Cu(II) for biological application was also performed in HepG2 cells.