全文获取类型
收费全文 | 8897篇 |
免费 | 477篇 |
国内免费 | 206篇 |
专业分类
化学 | 5543篇 |
晶体学 | 80篇 |
力学 | 362篇 |
综合类 | 25篇 |
数学 | 1458篇 |
物理学 | 2112篇 |
出版年
2023年 | 72篇 |
2022年 | 150篇 |
2021年 | 186篇 |
2020年 | 208篇 |
2019年 | 221篇 |
2018年 | 196篇 |
2017年 | 163篇 |
2016年 | 265篇 |
2015年 | 272篇 |
2014年 | 288篇 |
2013年 | 612篇 |
2012年 | 549篇 |
2011年 | 597篇 |
2010年 | 393篇 |
2009年 | 343篇 |
2008年 | 474篇 |
2007年 | 412篇 |
2006年 | 410篇 |
2005年 | 355篇 |
2004年 | 304篇 |
2003年 | 291篇 |
2002年 | 264篇 |
2001年 | 192篇 |
2000年 | 171篇 |
1999年 | 131篇 |
1998年 | 91篇 |
1997年 | 83篇 |
1996年 | 114篇 |
1995年 | 73篇 |
1994年 | 115篇 |
1993年 | 78篇 |
1992年 | 99篇 |
1991年 | 76篇 |
1990年 | 64篇 |
1989年 | 65篇 |
1988年 | 60篇 |
1987年 | 48篇 |
1986年 | 54篇 |
1985年 | 80篇 |
1984年 | 81篇 |
1983年 | 53篇 |
1982年 | 81篇 |
1981年 | 70篇 |
1980年 | 74篇 |
1979年 | 64篇 |
1978年 | 72篇 |
1977年 | 66篇 |
1976年 | 55篇 |
1975年 | 48篇 |
1973年 | 56篇 |
排序方式: 共有9580条查询结果,搜索用时 46 毫秒
11.
Thermodynamic study of transthyretin association (wild‐type and senile forms) with heparan sulfate proteoglycan: pH effect and implication of the reactive histidine residue 下载免费PDF全文
Ambre Geneste Claire André Nadine Magy‐Bertrand Lydie Lethier Gharbi Tijani Yves Claude Guillaume 《Biomedical chromatography : BMC》2015,29(4):514-522
The tetramer destabilization of transthyretin into monomers and its fibrillation are phenomena leading to amyloid deposition. Heparan sulfate proteoglycan (HSPG) has been found in all amyloid deposits. A chromatographic approach was developed to compare binding parameters between wild‐type transthyretin (wtTTR) and an amyloidogenic transthyretin (sTTR). Results showed a greater affinity of sTTR for HSPG at pH 7.4 compared with wtTTR owing to the monomeric form of sTTR. Analysis of the thermodynamic parameters showed that van der Waals interactions were involved at the complex interface for both transthyretin forms. For sTTR, results from the plot representing the number of protons exchanged vs pH showed that the binding mechanism was pH‐dependent with a critical value at a pH 6.5. This observation was due to the protonation of a histidine residue as an imidazolium cation, which was not accessible when TTR was in its tetrameric structure. At pH >6.5, dehydration at the binding interface and several contacts between nonpolar groups of sTTR and HSPG were also coupled to binding for an optimal hydrogen‐bond network. At pH <6.5, the protonation of the His residue from sTTR monomer when pH decreased broke the hydrogen‐bond network, leading to its destabilization and thus producing slight conformational changes in the sTTR monomer structure. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
12.
P Vincent A BrioudeC Journet S RabasteS.T Purcell J Le BrusqJ.C Plenet 《Journal of Non》2002,311(2):130-137
We report here the successful inclusion of carbon nanotubes (CNs) into a TiO2 matrix prepared by a sol-gel method. The presence of CNs in the sol-gel matrix and the structure of the film were analyzed principally by transmission electron microscopy. Complementary information about the behavior of embedded carbon nanotubes versus heat treatment and ion irradiation were obtained by X-ray photoelectron spectroscopy. The elaboration of an inorganic matrix containing embedded carbon nanotubes leads to a new nanocomposite. The possible applications of this nanocomposite are discussed. 相似文献
13.
P. Le Bars 《Journal of Combinatorial Theory, Series A》2006,113(8):1771-1782
The aggregate error locator is defined and a computation method is given. The aggregate error locator is then used in a type of Forney algorithm to compute the error values in the received words of a Ca,b algebraic geometry code. 相似文献
14.
We present some algorithms related to rings of Ore polynomials (or, briefly, Ore rings) and describe a computer algebra library
for basic operations in an arbitrary Ore ring. The library can be used as a basis for various algorithms in Ore rings, in
particular, in differential, shift, and q-shift rings.
__________
Translated from Sovremennaya Matematika i Ee Prilozheniya (Contemporary Mathematics and Its Applications), Vol. 13, Algebra,
2004. 相似文献
15.
从现有的PCDFs分子的正辛醇 /水分配系数 (logKow)实验数据出发 ,建立定量结构 性质关系方程(QSPR) .采用G98W程序包中的PM3方法对 13 5个多氯代二苯并呋喃 (PCDFs)分子和二苯并呋喃进行了优化计算 ,作业命令为 #pPM3optfreqscf(conver =9) ,以计算所得的分子轨道能量、碳原子电荷作为PCDFs分子结构描述符 ,运用多元线性回归技术建立了PCDFs的logKow与分子结构描述符的四元方程 ,最优相关系数为 0 .95 0 7,标准偏差为 0 .173 7,经检验该模型的稳健性好 ,并对未有实验数据的 85个PCDFs的logKow进行预测 相似文献
16.
O. Perru F. Ibrahim O. Bajeat C. Bourgeois F. Clapier E. Cottereau C. Donzaud M. Ducourtieux S. Galès D. Guillemaud-Mueller C. Lau H. Lefort F. Le Blanc A. C. Mueller J. Obert N. Pauwels J. C. Potier F. Pougheon J. Proust B. Roussière J. Sauvage O. Sorlin D. Verney 《Physics of Atomic Nuclei》2003,66(8):1421-1427
The PARRNe facility has been used to produce neutron-rich isotopes 83,84Gaby the ISOL method. Their decay has been studied, and β-γ coincidence and γ-γ coincidence data were collected as a function of time. The first two excited levels in 83Ge and the first excited level in 84Ge have been measured for the first time. 相似文献
17.
Franois Lavaud Michel Fontanille Yves Gnanou 《Journal of polymer science. Part A, Polymer chemistry》2004,42(19):4964-4975
Studies on the anionic polymerization of methyl methacrylate in tetrahydrofuran and in the presence of sparteine have revealed a beneficial effect due to this additive, resulting in a decrease in the extent of termination. Better control of the definition of the polymers formed can thus be achieved in the presence of this additive. On the other hand, macromolecular engineering requires a range of active species concentrations lower than 10?3 mol L?1 and particularly the synthesis of polymers of high molar masses. For a better understanding of the mechanism of chain growth under such concentration conditions, the kinetics of polymerization have been investigated with a technique based on adiabatic calorimetry. Sparteine has been found to lack sufficient cation‐binding power to prevent the propagating enolate ion pairs from aggregating. The rate constant of propagation of nonaggregated species has been estimated, as well as the aggregation constant of equilibrium. For very low initiator concentrations, termination reactions have been shown to profoundly alter the control of the polymerization and to prevent a quantitative monomer conversion. Theoretical maximal conversions have been calculated from kinetic data and compare well with the experimental values. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 4964–4975, 2004 相似文献
18.
Abraham Chemtob Valrie Hroguez Yves Gnanou 《Journal of polymer science. Part A, Polymer chemistry》2004,42(11):2705-2716
This study critically examines the similarities and differences between poly(ethylene oxide) (PEO) stabilized latices of polynorbornene and polybutadiene. Features such as the kinetics of copolymerization of norbornene and cyclooctadiene with a macromonomer of PEO, the particles' size and morphology, the type of copolymer formed, and the stability of these latices were investigated and the results obtained are considered. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 2705–2716, 2004 相似文献
19.
20.
Jérôme Le NôtreAna Acosta Martinez Pierre H DixneufChristian Bruneau 《Tetrahedron》2003,59(47):9425-9432
Enyne rearrangement of silylated modified terpenoids has been used as the key step for the synthesis of new terpenes and terpenoids. The catalytic system generated in situ from [RuCl2(p-cymene]2, 1,3-bis(mesityl)imidazolinium chloride and cesium carbonate is able to perform the transformation of silylated 1,7-enynes into cyclic siloxanes. Selective cleavage of the silicon-carbon and silicon-oxygen bonds by simple reactions has been performed to afford new terpenes and terpenoids by formal addition of a C5 unit. 相似文献