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991.
Arpansiree Wongmekiat Satoko Yoshimatsu Yuichi Tozuka Kunikazu Moribe Keiji Yamamoto 《Journal of inclusion phenomena and macrocyclic chemistry》2006,56(1-2):29-32
Drugs with poor water solubility were co-ground with cyclodextrins (CDs) to create nanoparticles with improved solubility characteristics. Indomethacin (IDM), furosemide (FRM) and naproxen (NAP) were co-ground with β-CD at the molar ratio of 2:1 (CD:drug). Co-grinding of a drug with CD resulted in not only the formation of drug nanoparticles but also the solubilization of the drug by inclusion complex formation with CD in aqueous media. The nanoparticle fraction of IDM, and FRM from ground mixtures prepared with β-CD was as high as 60–70% while the solubilization fraction was less than 10%. In contrast, β-CD–NAP ground mixture showed a large fraction, 48%, for drug solubilization and only 4% for nanoparticle formation. Furosemide ground mixtures prepared with α-CD, β-CD and γ-CD showed comparatively high nanoparticle fraction while the solubilization fraction was around 10%. Both the nanoparticle fraction and the solubilization fraction were greater in the IDM–β-CD system than those in γ-CD and α-CD systems. The nanoparticle formation of NAP depended on the types of CD used as a co-grinding additive. Naproxen nanoparticles could be prepared by co-grinding NAP and α-CD, while the solubilization of NAP tended to improve when β-CD or γ-CD was used. 相似文献
992.
Y. Suzuki T. Nankawa T. Yoshida T. Ozaki T. Ohnuki A. J. Francis S. Tsushima Y. Enokida I. Yamamoto 《Journal of Radioanalytical and Nuclear Chemistry》2005,266(2):199-204
Summary We have investigated the structure of Eu(III)-citrate complexes in aqueous solution and their degradability by Pseudomonas fluorescens. Analysis of 1:1, 1:2, and 1:5 Eu(III):citrate solutions at pH 7 by electrospray ionization mass spectrometry (ESI-MS) showed
that the 2:2 Eu(III)-citrate complex is the predominant complex species at a low citrate/Eu(III) ratio, while at a high ratio,
a 1:2 Eu(III)-citrate complex is formed preferably. Studies on the biodegradation of Eu(III)-citrate complex by P. fluorescens have shown that a 2:2 Eu(III)-citrate complex is resistent to degradation while a 1:2 complex transforms to a 2:2 complex
with the degradation of excess citric acid. 相似文献
993.
Tonegawa H Kuboe Y Amaike M Nishida A Ohkawa K Yamamoto H 《Macromolecular bioscience》2004,4(5):503-511
Poly(L-lysine)s having an Nepsilon-substituted tetrapeptide, Lys-Gly-Tyr-Gly, were synthesized by the coupling of the protected tetrapeptide active ester, Boc-Lys(Z)-Gly-Tyr(Bzl)-Gly (4-hydroxyphenyl)dimethylsulfonium methylsulfate and Nepsilon-group of the poly(L-lysine) side chain. The Nepsilon-substituted tetrapeptide functions as the substrate of tyrosinase and is responsible for the enzyme-mediated interpolymer cross-linking. The degree of Nepsilon-substitution (DS) was mostly controlled by changing the stoichiometry between the Nepsilon-amino groups of the parent poly(L-lysine) and the protected tetrapeptide active ester. Two kinds of samples having DS values of 8.6 and 18 mol-% were prepared. The resulting cationic Nepsilon-(Lys-Gly-Tyr-Gly)-poly(L-lysine) (abbreviated as PLL(GYGK)) was spun into hybrid fibers with the anionic polysaccharide gellan via a polyionic complexation reaction at the interface between aqueous solutions of the two polymers. The mechanical strengths of the PLL(GYGK)-gellan hybrid fibers were superior to those of the original poly(L-lysine)-gellan fibers. The mechanical strength of the hybrid fibers further increased upon the tyrosinase-mediated cross-linking reaction of the PLL(GYGK). This result indicates that the covalent cross-bridge formation between the Nepsilon-substituted peptides significantly contributed to reinforcement of the hybrid fibers. The present study affords a new methodology for reinforcement inspired by a biological process. 相似文献
994.
T. Shinohara M. Fujioka H. Onodera K. Hisatake H. Yamamoto H. Watanabe 《Hyperfine Interactions》1975,1(1):345-360
From internal conversion experiments and the Mössbauer effect measurements, the 4s electron density and isomer shift for Fe impurity atoms in Cr, Ni, Cu, Pt and Au metals were studied. The M and N shell conversion electron spectra of the 14.4 keV transition of57Fe were measured using a high resolution β-ray spectrometer and analyzed using a deconvolution methods. The Mössbauer effect measurements were performed by a standard spectrometer with a moving absorber. Most of the samples showed isomer shift values consistent with the published ones. It is concluded that the 4s electron density, \(\rho _{4_S} (0)\) , at the nucleus of57Fe embedded is nearly equal in these host metals. The relation between \(\rho _{4_S} (0)\) and the isomer shift indicates that \(\rho _{3_S} (0)\) plays an important role in the variation of the isomer shift. 相似文献
995.
Let Γ be a fuchsian group which preserves the unit disc Δ and hence also its complement Δ* in the Riemann sphere
. The Bers embedding represents the Teichm=:uller space T(Γ) of Γ in the space (B (Δ*, Γ) of bounded quadratic differentials for Γ in Δ*. Then, T(Γ) is included in the closed ball centred at the origin of radius 6 inB(Δ*, Γ) with respect to the norm employed in a paper by Nehari [The Schwarzian derivative and Schlicht functions; Bull. Amer.
Math. Soc. 55 (1949), 545–551]. In other words the outradiuso(Γ) ofT(Γ) is not greater than 6. The purpose of this paper is to give a complete characterization of a fuchsian group Γ for which
the outradiuso(Γ) ofT(Γ) attains this extremal value 6. The main theorem is: Let Γ be a fuchsian group preserving Δ*. Then the outradiuso(Γ) of the Teichmüller spaceT(Γ) equals 6 if and only if for any positive numberd, either (i) there exists a hyperbolic disc of radiusd precisely invariant under the trivial subgroup, or (ii) there exists the collar of widthd about the axis of a hyperbolic element of Γ.
Dedicated to Professor K?taro Oikawa on his 60th birthday 相似文献
996.
Ruckstuhl W Stroynowski R Atwood WB Barish BC Bonneaud GR Courau A Donaldson GJ Dubois R Duro MM Elsen EE Gao SG Huang YZ Irwin GM Johnson RP Kichimi H Kirkby J Klem DE Koop DE Ludwig J Mills GB Ogawa A Pal T Pitthan R Pollard DL Prescott CY Rochester LS Sakuda M Sherman SS Wang SQ Wojcicki SG Yamamoto H Yan WG Young CC 《Physical review letters》1986,56(20):2132-2135
997.
Goto M Yamamoto Y Sumimoto M Tsuruda N Kurosaki H 《Chemical & pharmaceutical bulletin》2003,51(10):1157-1162
Square-planar complexes with the formula [Pt(L(2))(L(1))](X)(2) x nH(2)O, where L(1) is S-2-aminomethylpyrrolidine (S-pyrda) or 2-aminomethylpiperidine (pipda) and L(2) is diammine (X=Cl), cyclobutane-1,1-dicarboxylato (cbdca) (X=none), 2,2'-bipyridine (bpy) (X=NO(3)), or 1,10-phenanthroline (phen) (X=Cl), were prepared and the nature of the coordination of L(1) was examined by (1)H-NMR spectroscopy and X-ray crystallography. These 2-aminomethylazacycloalkane derivatives form five-membered chelate rings condensed with an azacycloalkane ring in cis- or trans-configurations. The (1)H-NMR spectrum of complexes with S-pyrda as L(1) were consistent with cis-condensed rings in an S(N) conformation with any of L(2) group. However, (1)H-NMR spectra of the complexes with pipda as L(1) indicated trans-fused successive rings for the diammine and cbdca as L(2), but spectra for bpy and phen as L(2) were consistent with a conformation having cis-fused successive rings. X-Ray crystallography data for the two complexes with pipda as L(1) and cbdca (1) and bpy (2) as L(2) confirms the different coordination behavior in the solid state. 相似文献
998.
This communication presents studies that illustrated nitroso Diels-Alder adduct has been obtained in uniformly high enantioselectivity via a tandem nitroso aldol/Michael reaction using an amine catalyst. The regiochemical outcome of this construction is documented to be the opposite to that of the normal nitroso aldol reaction, which has been determined by X-ray analysis. The reaction of the enone with silver-BINAP catalyst has also been investigated in conjunction with the control of regiochemistry in a stepwise process. 相似文献
999.
Kunishima M Yamamoto K Watanabe Y Hioki K Tani S 《Chemical communications (Cambridge, England)》2005,(21):2698-2700
A novel immobilized dehydrocondensing reagent comprised of a triazine-type dehydrocondensing reagent itself in a polymerized form was synthesized by copolymerization between tetra(ethylene glycol) bis(dichlorotriazinyl) ether and tris(2-aminoethyl)amine. 相似文献
1000.
Benten H Ohkita H Ito S Yamamoto M Tohda Y Tani K 《The Journal of chemical physics》2005,123(8):084901
Photoinduced intramolecular charge separation (CS) in a polar polymer glass, cyanoethylated pullulan (CN-PUL), was studied below the glass transition temperature (Tg=395 K). A series of three carbazole (Cz: donor)-cyclohexane (S: spacer)-acceptor (A: acceptor) molecules (Cz-S-A) was used as intramolecular donor-acceptor dyads. The photoinduced CS rate was evaluated by the fluorescence decay measurement at temperatures from 100 to 400 K. The CS rate (kCS) increased above 200 K even far below Tg where micro-Brownian motions of the whole polymer chain are frozen. Below 200 K, on the other hand, kCS showed weak dependence on temperature. The temperature dependence of kCS is discussed in terms of the dielectric relaxation time of the polymer matrix. Consequently, CS below Tg was well explained by a thermally nonequilibrium electron transfer (ET) formula above 200 K and by a two-mode quantum-mechanical ET formula below 200 K. The increase in kCS above 200 K is mainly caused by a thermally activated low-frequency matrix mode originating from the side-chain relaxation of polar cyano groups. The weak temperature dependence of kCS can be explained by a nuclear-tunneling effect caused by a high-frequency matrix mode (variant Planck's over 2piomegH=250 cm-1) and an intramolecular vibrational mode (variant Planck's over 2piomegaQ=1300 cm-1). The high-frequency mode of the polymer matrix was attributed to a vibrational or librational motion of polar groups in the CN-PUL glassy solid. 相似文献