全文获取类型
收费全文 | 273篇 |
免费 | 11篇 |
专业分类
化学 | 258篇 |
力学 | 2篇 |
数学 | 5篇 |
物理学 | 19篇 |
出版年
2023年 | 1篇 |
2022年 | 3篇 |
2021年 | 3篇 |
2020年 | 3篇 |
2019年 | 7篇 |
2018年 | 5篇 |
2017年 | 4篇 |
2016年 | 9篇 |
2015年 | 6篇 |
2014年 | 6篇 |
2013年 | 15篇 |
2012年 | 16篇 |
2011年 | 19篇 |
2010年 | 11篇 |
2009年 | 5篇 |
2008年 | 20篇 |
2007年 | 17篇 |
2006年 | 17篇 |
2005年 | 27篇 |
2004年 | 22篇 |
2003年 | 17篇 |
2002年 | 14篇 |
2001年 | 3篇 |
2000年 | 1篇 |
1999年 | 4篇 |
1998年 | 5篇 |
1997年 | 2篇 |
1996年 | 5篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1989年 | 1篇 |
1987年 | 1篇 |
1985年 | 7篇 |
1982年 | 2篇 |
1977年 | 1篇 |
1968年 | 1篇 |
排序方式: 共有284条查询结果,搜索用时 15 毫秒
91.
Direct conversion of epoxides to aziridines was achieved with guanidines as a nitrogen source. Stereochemical inversion at the chiral centers of epoxides was observed without loss of optical purity. 相似文献
92.
Nishimura K Tsumagari H Morioka A Yamauchi Y Miyashita K Lu S Jisaka M Nagaya T Yokota K 《Applied biochemistry and biotechnology》2002,102(1-6):239-250
The arachidonate cascade includes the cyclooxygenase (COX) pathway to form prostanoids and the lipoxygenase (LOX) pathway
to generate several oxygenated fatty acids, collectively called eicosanoids. Eicosanoids are suggested to play a dual role
in regulating cell survival and apoptosis in various types of cells through an unknown mechanism. We found apoptosis in cultured
Madin-Darby canine kidney (MDCK) cells treated with 12-O-tetradecanoylphorbol β-acetate (TPA), a potent tumor promoter, and nordihydroguaiaretic acid (NDGA), a LOX inhibitor. The
effect of TPA was synergistically stimulated along with NDGA. Aspirin, a COX inhibitor, was not effective. The target of NDGA
might be different from the mechanism involving a LOX activity in some kinds of carcinoma cells because the increased expression
of 12-LOX was not detected in MDCK cells treated with TPA. Caspase and poly(ADP-ribose) metabolites were found to be involved
in the signal transduction pathway of the TPA- and NDGA-induced apoptosis in MDCK cells. Alternatively, hydrogen peroxide-induced
apoptosis was not affected by NDGA. Thus, the TPA-induced response involved the mechanism independent of the oxidative stress.
Obesity is a risk factor for severe diseases including noninsulin-dependent diabetes and atherosclerosis characterized by
the changes of cell properties of adipocytes. We found that conjugated linolenic acid from bitter gourd was able to induce
apoptosis in mouse preadipogenic 3T3-L1 cells. The findings provide the potential use of conjugated fatty acids to regulate
obesity. 相似文献
93.
Porphyrin dimers were prepared from beta,beta'-dipyrrole derivatives via the double pyrrolylmethylation followed by double [2 + 2] MacDonald porphyrin synthesis. 相似文献
94.
Toyoshima Atsushi Mitsukai Akina Tsukada Kazuaki Ooe Kazuhiro Haba Hiromitsu Komori Yukiko Murakami Masashi Kaneya Yusuke Sato Daisuke Asai Masato Sato Tetsuya K. Nagame Yuichiro 《Journal of Radioanalytical and Nuclear Chemistry》2018,317(1):421-430
Journal of Radioanalytical and Nuclear Chemistry - We have studied extraction behavior of group-6 elements Mo and W to search for suitable conditions for an on-line extraction experiment of their... 相似文献
95.
Masaki Asai Yukiko Takemoto Ayaka Deguchi Yasunao Hattori Hidefumi Makabe 《Tetrahedron: Asymmetry》2017,28(11):1582-1586
The synthesis of (+)-monomorine I, an indolizidine alkaloid isolated from Monomorium pharaonis, has been achieved. The 2,6-cis-piperidine ring moiety of (+)-monomorine I was constructed using diastereoselective aminopalladation. Chain elongation via cross-metathesis using Hoveyda-Grubbs 2nd catalyst followed by deprotection of the Cbz group and cyclic reductive hydroamination afforded (+)-monomorine I. 相似文献
96.
97.
Tomoki Saka Toru Okaki Shohei Ifuku Yukiko Yamashita Kasumi Sato Shota Miyawaki Akiko Kamori Atsushi Kato Isao Adachi Yasuhiro Tezuka Peter G. Kiria Osamu Onomura Daishiro Minato Kenji Sugimoto Yuji Matsuya Naoki Toyooka 《Tetrahedron》2013
Synthesis and inhibitory activities against α-l-fucosidase of phenylalkyl-substituted polyhydroxypiperidines have been described. Among the newly synthesized compounds, 2,4,6-trichloro derivative (16q) showed very high inhibitory activity against α-l-fucosidase with IC50 value of 0.005 μM, and Ki values of 0.0011 μM, respectively. 相似文献
98.
Qian He Yoshinori Takizawa Takahiro Hayasaka Noritaka Masaki Yukiko Kusama Jiping Su Hiroyuki Mineta Mitsutoshi Setou 《Analytical and bioanalytical chemistry》2014,406(24):5815-5825
Warthin tumor (War-T), the second most common benign salivary gland tumor, consists mainly of neoplastic epithelium and lymphoid stroma. Some proteins and genes thought to be involved in War-T were evaluated by molecular biology and immunology. However, lipids as an important component of many tumor cells have not been well studied in War-T. To elucidate the molecular biology and pathogenesis of War-T, we investigated the visualized distribution of phosphatidylcholines (PCs) by imaging mass spectrometry (IMS). In our IMS analysis of a typical case, 10 signals were significantly different in intensity (p?0.01) between the War-T and non-tumor (Non-T) regions. Five specific PCs were frequently found in the War-T regions of all of the samples: [PC (16:0/16:0)?+?K]+ (m/z 772.5), [PC (16:0/20:4)?+?K]+ (m/z 820.5), [PC (16:0/20:3)?+?K]+ (m/z 822.5), [PC (18:2/20:4)?+?K]+ (m/z 844.5), and [PC (18:0/20:5)?+?K]+ (m/z 846.5). PC (16:0/16:0) was increased specifically in the folliculus lymphaticus of War-T lymphoid stroma, suggesting a different metabolism. Localization of PC (16:0/16:0) might reflect inflammation activity participating in the pathogenesis of War-T. Thus, our IMS analysis revealed the profile of PCs specific to the War-T region. The molecules identified in our study provide important information for further studies of War-T pathogenesis. 相似文献
99.
Higashi T Yokoi H Nagura Y Nishio T Shimada K 《Biomedical chromatography : BMC》2008,22(12):1434-1441
The development and validation of liquid chromatography-electrospray ionization-tandem mass spectrometric (LC-ESI-MS/MS) methods that enable the quantification of neuroactive androgens, androsterone (5alpha-androstan-3alpha-ol-17-one, 3alpha,5alpha-A) and 5alpha-androstane-3alpha,17beta-diol (3alpha,5alpha-Adiol), in the rat brain and serum are presented. The androgens were extracted with methanol-acetic acid, purified using solid-phase extraction cartridges, derivatized with an ESI-active reagent, isonicotinoyl azide (INA), and then subjected to LC-ESI-MS/MS. The quantifications were based on selected reaction monitoring mode using the characteristic transitions of the INA derivatives. The methods allowed the reproducible and accurate quantification of the brain and serum neuroactive androgens using a 100 mg or 100 microL sample; the intra- and inter-assay relative standard deviations were below 3.6%, and the percentage accuracy values were 97.1-103.7% for both androgens. The animal study using the methods suggests that most of 3alpha,5alpha-Adiol found in the brain is derived from the periphery, while 3alpha,5alpha-A is not only transported from the periphery into the brain, but also synthesized in the brain by the oxidation of 3alpha,5alpha-Adiol. The androgens in the rats intraperitoneally administered finasteride, a 5alpha-reductatse inhibitor, were also measured; this treatment significantly reduced the brain 3alpha,5alpha-A and 3alpha,5alpha-Adiol levels and increased only the brain level of androstenedione, the precursor of 3alpha,5alpha-A. 相似文献
100.
Tomonori Mori Dr. Shuhei Higashibayashi Dr. Taiji Goto Mitsunori Kohno Yukiko Satouchi Kazuyuki Shinko Kengo Suzuki Shunya Suzuki Hiraku Tohmiya Kimiko Hashimoto Prof. Dr. Masaya Nakata Prof. Dr. 《化学:亚洲杂志》2008,3(6):984-1012
The five practical segments for the total synthesis of siomycin A, that is, the dehydropiperidine segment A ( 5 ), the pentapeptide segment B ( 3 ), the dihydroquinoline segment C ( 6 ), and the β‐phenylselenoalanine dipeptide segments D ( 7 ) and E ( 4 ), were synthesized. Segment A ( 5 ) was constructed by the coupling of the azomethine ylide and the chiral sulfinimine, followed by the stereoselective reduction of the six‐membered imine function. Segment B ( 3 ) was synthesized by the phenylselenylation of the β‐lactone, stereoselective vinylzinc addition to the chiral sulfinimine, and oxazoline–thioamide conversion. Segment C ( 6 ) was prepared by the one‐pot olefination of the tetrahydroquinoline N‐oxide using triflic anhydride and triethylamine, stereoselective reduction of the methyl ketone function, and regioselective Yb(OTf)3‐catalyzed epoxide opening by the amino group. Segments D ( 7 ) and E ( 4 ) were synthesized by coupling of the properly protected β‐phenylselenoalanines. 相似文献