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91.
Masumi Torii Yuki Hitora Hikaru Kato Yuhei Koyanagi Teppei Kawahara Fitje Losung Remy E.P. Mangindaan Sachiko Tsukamoto 《Tetrahedron》2018,74(52):7516-7521
Four new sulfonated serinol derivatives, siladenoserinols M–P (1–4), were isolated from a tunicate of the family Didemnidae collected in Indonesia. Their chemical structures were elucidated by the interpretation of NMR and mass spectroscopic data. Two of them (2 and 4) were revealed to be disulfonate serinol derivatives, and the others were monosulfonates. Siladenoserinols A (5) and B (6), which we previously isolated from the same tunicate, inhibited the p53–Hdm2 interaction with an IC50 value of 2.0?μM. However, 1–4 did not inhibit the activity. The result suggested that the acetyl group in the bicyclic ketal unit and/or the glycerophospholipid moiety in 5 and 6 were responsible for the inhibition of the p53–Hdm2 interaction. 相似文献
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94.
Yuki Hirose Kaori Hashiya Dr. Toshikazu Bando Prof. Dr. Hiroshi Sugiyama 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(8):2782-2788
Hairpin pyrrole-imidazole polyamides (hPIPs) and their chlorambucil (Chb) conjugates (hPIP-Chbs) can alkylate DNA in a sequence-specific manner, and have been studied as anticancer drugs. Here, we conjugated Chb to a cyclic PIP (cPIP), which is known to have a higher binding affinity than the corresponding hPIP, and investigated the DNA alkylation properties of the resulting cPIP-Chb using the optimized capillary electrophoresis method and conventional HPLC product analysis. cPIP-Chb conjugate 3 showed higher alkylation activity at its binding sites than did hPIP-Chb conjugates 1 and 2 . Subsequent HPLC analysis revealed that the alkylation site of conjugate 3 , which was identified by capillary electrophoresis, was reliable and that conjugate 3 alkylates the N3 position of adenine as do hPIP-Chbs. Moreover, conjugate 3 showed higher cytotoxicity against LNCaP prostate cancer cells than did conjugate 1 and cytotoxicity comparable to that of conjugate 2 . These results suggest that cPIP-Chbs could be novel DNA alkylating anticancer drugs. 相似文献
95.
We can perceive a surface through another surface. This perception is called transparency. It is known that transparency can be perceived even if the stimulus conditions are not consistent with physical conditions for a real transparent surface. In this study, we measured the ranges of luminance and chromaticity of the overlapping area of two crossed layers at which a surface was perceived as chromatically-uniform transparent. As the results, the luminance range of the overlapping area existed around or near the luminance of the inducing area. The upper and lower limits of the luminance range were higher for the dark background than for the light background. Moreover, the chromatic range existed around the additive colormixture line between two chromaticities of the inducing areas for both dark and light backgrounds. This indicates that the perceptual transparency mechanism would divide the color of an additive color mixture into the original colors that exist in the inducing areas. We noticed that the perceptual appearance of the stimulus changed greatly depending on the luminances of the overlapping area and the background. These differences in perceptual appearance would be a factor explaining individual difference and deciding the luminance conditions for transparency. 相似文献
96.
H Shintani 《Journal of chromatography. A》1986,378(1):95-108
A column-switching method which combines ion-exchange and ion-pair reversed-phase chromatography was developed for the determination of serum uremic toxins, cations and anions. Serum urea, which was poorly separated by reversed-phase chromatography, was analyzed using an immobilized-urease column and detected by post-column colorimetry. Apart from the simultaneous analysis, anion analysis using ion-pair reversed-phase chromatography on an ODS column was also developed. The origin of the system peak observed in anion analysis with an eluent containing phthalate has been clarified. 相似文献
97.
Treatment of alkynes with ortho-formyl and acetyl phenylboronic acids in the presence of a cobalt catalyst resulted in the formation of 2,3-disubstituted indenols in good yields. When aryl silyl alkynes were used, 2-aryl-3-silyl indenols were obtained regioselectively in good yields. 相似文献
98.
Morphological change of crystalline polymer films by annealing: substrate‐ and heating/cooling‐rate‐dependent surface roughness 下载免费PDF全文
Yuki Uto Keisuke Mizobata Sandeep Kumar Maurya Tsuyoshi Akiyama Takashi Nakajima 《Surface and interface analysis : SIA》2017,49(7):577-583
We study the morphological change of crystalline polymer films by annealing using atomic force microscope, X‐ray diffraction, and Fourier transform infrared spectroscopy techniques. As typical samples, we employ high‐density and low‐density polyethylene films prepared by the cast method. After annealing at 135 °C for 4 h, the surface roughness of polyethylene films by the atomic force microscope significantly increases, and the crystallite size by the X‐ray diffraction also shows some increase, while the Fourier transform infrared spectroscopy spectrum hardly exhibits any change. This can be well explained as a result of the growth of crystal structure by recrystallization during annealing. More interestingly, we find that the choice of the substrate and also the heating/cooling rates for annealing significantly influences the surface roughness of the films. Copyright © 2017 John Wiley & Sons, Ltd. 相似文献
99.
Keiki Kishikawa Yuki Furukawa Tomohiro Watanabe Michinari Kohri Tatsuo Taniguchi Shigeo Kohmoto 《Liquid crystals》2017,44(8):1332-1339
Blue phases (BPs) obtained by doping a commercially available liquid crystalline compound (4-butyl-N-(4-ethoxybenzylidene)aniline (EBBA)) with (2R,3R)-2,3-bis(4-octyloxyphenylbenzoyloxy)-N-(hydroxydecyl)succinimide (1) were highly stabilised by the addition of a small amount of alkane diols. Especially, addition of only 0.5 mol% of octane-1,8-diol increased the BP–Iso transition temperature by 10 K and widened the BP temperature range up to 35 K. A model stabilisation mechanism based on the construction of a hydrogen bond network in each disclination zone in BPs was proposed. 相似文献
100.
A moderately hydrophobic ionic liquid, tributyl(2-methoxyethyl)phosphonium bis(pentafluoroethanesulfonyl)amide ([TBMOEP+][C2C2N−]), shows a very stable liquid junction potential upon contact with an aqueous solution whose ionic strength is as low as 1 μmol dm−3. The stability with the maximum excursion of the potential within ±0.5 mV for 30 min is very promising for accurate determination of pH and other single ion activities potentiometrically. 相似文献