Sortase-Mediated Transpeptidation for Site-Specific Modification of Peptides, Glycopeptides, and Proteins

Sortases are a family of transpeptidases found in Gram-positive bacteria responsible for covalent anchoring of cell surface proteins to bacterial cell walls. It has been discovered that sortase A (SrtA) of Staphylococcus aureus origin is rather promiscuous and can accept various molecules as substrates. As a result, SrtA has been widely used to ligate peptides and proteins with a variety of nucleophiles, and the ligation products are useful for research in chemical biology, proteomics, biomedicine, etc. This review summarizes the recent applications of SrtA with special emphasis on SrtA-catalyzed ligation of carbohydrates with peptides and proteins.     

Turing structures and stability for the 1-D Lengyel–Epstein system

This paper continues the analysis on the Lengyel–Epstein reaction- diffusion system of the chlorite-iodide-malonic acid-starch (CIMA) reaction for the rich Turing structures. The steady state structures, especially the double bifurcation one, and their stability and multiplicity are studied by the use of Lyapunov–Schmidt reduction technique and singularity theory. Numerical simulations are presented to support our theoretical studies. The results show that the richer stationary Turing patterns heavily rely both on the size of the reactor and on the effective diffusion rate in the CIMA reaction.     

Synthesis and characterization of phenol‐based biaryl proton conducting polymers

Biaryl hydroxy polymers with orthogonal disposition of proton transporting ? OH moieties have been synthesized via conventional free radical polymerization. The polymers are characterized for their thermal stability and proton conductivity, and the results are compared with the corresponding styrenic hydroxy polymers. The orthogonal disposition of ? OH moieties in biaryl polymers does result in lower E_a for proton transport. However, the lower E_a values in biaryl polymers did not translate into a net increase in proton conductivity. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012     

AMS theme collection on “Mechanics of Nanomaterials”

正This themed collection on Mechanics of Nanomaterials consists of five papers, including one review article. With our ability to control and manipulate matter at atomic level developed with the invention of atomic force microscope since 1980s, novel materials with feature size ranged from a few nanometer to hundreds of nanometer     

香豆素、罗丹明衍生物和DCM激光染料分子间的激发能传递

通过考察香豆素4-DCM、香豆素481-DCM、否豆素540A-罗丹明6G、香豆素540A-罗丹明640在乙醇、乙二醇等极性溶剂中的激发光谱和荧光发射光谱,研究了它们之间的激发能传递过程。     

低温下使用的金刚石对顶砧高压盒和显微光谱系统

自Bridgeman发明套筒活塞高压装置以来,特别是引入金刚石压砧后,高压物理学发展迅速。这种金刚石对顶砧压力盒,简称为DAC,为研究高压下材料的光学性质提供了极大的方便。为进行高压低温研究,目前国内都是将压机浸入液氮中,或向DAC喷浇液氮。这样只能在77K恒温,且必须取出压机后才能加压。