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11.
H. Ohkita K. Ishibashi D. Tsurumoto A. Tagaya Y. Koike 《Applied Physics A: Materials Science & Processing》2005,81(3):617-620
We report on a method to compensate the photoelastic birefringence of a polymer. In this method, a rod-like molecule that has a polarizability anisotropy was chosen and doped in a polymer. We demonstrated this method by compensating the negative photoelastic birefringence of poly(methylmethacrylate) at a wavelength of 633 nm. Homogeneous doping with 2.2 wt. % of trans-stilbene almost eliminated the photoelastic birefringence of the polymer. The photoelastic coefficient of the synthesized zero-photoelastic birefringence polymer was 0.057×10-12 Pa-1. We found that the photoelastic birefringence of poly(methylmethacrylate) was compensated by the motion of trans-stilbene in the polymer by the analysis of the infrared absorption spectrum. PACS 42.70.-a; 42.70.Jk; 78.30.Jw 相似文献
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Fukuta Y Mita T Fukuda N Kanai M Shibasaki M 《Journal of the American Chemical Society》2006,128(19):6312-6313
An asymmetric ring-opening reaction of meso-aziridines with TMSN3 was developed using a catalyst prepared from Y(OiPr)3 and chiral ligand 2 in a 1:2 ratio. Excellent enantioselectivity was realized from a wide range of substrates with a practical catalyst loading. The products were efficiently converted to enantiomerically enriched 1,2-diamines, which are versatile chiral building blocks for pharmaceuticals and chiral ligands. This reaction was applied to a catalytic asymmetric synthesis of Tamiflu, a very important anti-influenza drug containing a chiral 1,2-diamino functionality. 相似文献
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JS Park Y Hirana S Mouri Y Miyauchi N Nakashima K Matsuda 《Journal of the American Chemical Society》2012,134(35):14461-14466
Understanding of electronic and optical features of single-walled carbon nanotubes (SWNTs) has been a central issue in science and nanotechnology of carbon nanotubes. We describe the detection of both the positive trion (positively charged exciton) and negative trion (negatively charged exciton) as a three-particle bound state in the SWNTs at room temperature by an in situ photoluminescence spectroelectrochemistry method for an isolated SWNT film cast on an ITO electrode. The electrochemical hole and electron dopings enable us to detect such trions on the SWNTs. The large energy difference between the singlet bright exciton and the negative and positive trions showing a tube diameter dependence is determined by both the exchange splitting energy and the trion binding energy. In contrast to conventional compound semiconductors, on the SWNTs, the negative trion has almost the same binding energy to the positive trion, which is attributed to nearly identical effective masses of the holes and electrons. 相似文献
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Khatayevich D So CR Hayamizu Y Gresswell C Sarikaya M 《Langmuir : the ACS journal of surfaces and colloids》2012,28(23):8589-8593
The systematic control over surface chemistry is a long-standing challenge in biomedical and nanotechnological applications for graphitic materials. As a novel approach, we utilize graphite-binding dodecapeptides that self-assemble into dense domains to form monolayer-thick long-range-ordered films on graphite. Specifically, the peptides are rationally designed through their amino acid sequences to predictably display hydrophilic and hydrophobic characteristics while maintaining their self-assembly capabilities on the solid substrate. The peptides are observed to maintain a high tolerance for sequence modification, allowing control over surface chemistry via their amino acid sequence. Furthermore, through a single-step coassembly of two differently designed peptides, we predictably and precisely tune the wettability of the resulting functionalized graphite surfaces from 44° to 83°. The modular molecular structures and predictable behavior of short peptides demonstrated here give rise to a novel platform for functionalizing graphitic materials that offers numerous advantages, including noninvasive modification of the substrate, biocompatible processing in an aqueous environment, and simple fusion with other functional biological molecules. 相似文献
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K Watanabe Y Nishimura T Nomoto N Umemoto Z Zhang B Zhang J Kuroyanagi Y Shimada T Shintou M Okano T Miyazaki T Imamura T Tanaka 《BMC neuroscience》2012,13(1):101
ABSTRACT: BACKGROUND: Successful delivery of compounds to the brain and retina is a challenge in the development of therapeutic drugs and imaging agents. This challenge arises because internalization of compounds into the brain and retina is restricted by the blood--brain barrier (BBB) and blood-retinal barrier (BRB), respectively. Simple and reliable in vivo assays are necessary to identify compounds that can easily cross the BBB and BRB. METHODS: We developed six fluorescent indoline derivatives (IDs) and examined their ability to cross the BBB and BRB in zebrafish by in vivo fluorescence imaging. These fluorescent IDs were administered to live zebrafish by immersing the zebrafish larvae at 7--8 days post fertilization in medium containing the ID, or by intracardiac injection. We also examined the effect of multidrug resistance proteins (MRPs) on the permeability of the BBB and BRB to the ID using MK571, a selective inhibitor of MRPs. RESULTS: The permeability of these barriers to fluorescent IDs administered by simple immersion was comparable to when administered by intracardiac injection. Thus, this finding supports the validity of drug administration by simple immersion for the assessment of BBB and BRB permeability to fluorescent IDs. Using this zebrafish model, we demonstrated that the length of the methylene chain in these fluorescent IDs significantly affected their ability to cross the BBB and BRB via MRPs. CONCLUSIONS: We demonstrated that in vivo assessment of the permeability of the BBB and BRB to fluorescent IDs could be simply and reliably performed using zebrafish. The structure of fluorescent IDs can be flexibly modified and, thus, the permeability of the BBB and BRB to a large number of IDs can be assessed using this zebrafish-based assay. The large amount of data acquired might be useful for in silico analysis to elucidate the precise mechanisms underlying the interactions between chemical structure and the efflux transporters at the BBB and BRB. In turn, understanding these mechanisms may lead to the efficient design of compounds targeting the brain and retina. 相似文献
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Dr. Yoshinori Tokairin Yuhei Shigeno Dr. Jianlin Han Prof. Dr. Gerd-Volker Röschenthaler Dr. Hiroyuki Konno Dr. Hiroki Moriwaki Vadim A. Soloshonok 《ChemistryOpen》2020,9(1):93-96
Four differently substituted chiral Ni(II)-complexes of dehydroalanine Schiff base were prepared and reacted with BrCF2COOEt/Cu under the standard reaction conditions. The observed diastereoselectivity was found to depend on the degree and pattern of chlorine substitution for hydrogen in the structure of the dehydroalanine complexes. The unsubstituted complex gave the ratio of diastereomers (S)(2S)/(S)(2R) of 66/34. On the other hand, introduction of chlorine atoms in the strategic positions on the chiral ligands allowed to achieve a practically attractive diastereoselectivity of (∼98.5/1.5). Diastereomerically pure major product was disassembled to prepare 9-fluorenylmethyloxycarbonyl (Fmoc) derivative of (S)-4,4-difluoroglutamic acid. 相似文献
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Nobuhito Imanaka Toshiyuki Masui Yuhei Mayama Kazuhiko Koyabu 《Journal of solid state chemistry》2005,178(11):3601-3603
Crystalline yttrium oxycarbonate, Y2O2CO3, was synthesized by our original flux method using the 0.476Li2CO3-0.270Na2CO3-0.254K2CO3 eutectic mixture at 450 °C. The oxycarbonate was characterized by X-ray powder diffraction (XRD), thermogravimetric analysis (TGA), and Fourier-transfer infrared spectroscopy (FT-IR). The Y2O2CO3 prepared by the flux method was a crystalline single phase of hexagonal rare earth oxycarbonate (type-II). This is the first report on the single-phase synthesis of crystalline hexagonal type-II Y2O2CO3. 相似文献