A new isoprenyl phenyl ether compound from mangrove fungus

A new isoprenyl phenyl ether, 3-hydroxy-4-(3-methylbut-2-enyloxy)benzoic acid methyl ester (1), together with 4-hydroxybenzoic acid (2), 2-hydroxy-6-methylbenzoic acid (3), and 4-hydroxy-3-methoxybenzoic acid (4) were isolated from Mangrove fungus (No. B60) from the South China Sea. The structures of the compounds were established on the basis of NMR spectroscopic and mass spectrometric data. In the preliminary bioassay, compound 1 exhibited antibacterial and antifungal activities. Compound 1 also inhibited cytotoxicity to the hepG2 cell line with an IC₅₀ value of 10.0 μg/mL. Published in Khimiya Prirodnykh Soedinenii, No. 4, pp. 313–314, July–August, 2007.     

ELECTROSPRAYING/ELECTROSPINNING OF POLY(γ-STEARYL-L-GLUTAMATE): FORMATION OF SURFACES WITH SUPERHYDROPHOBICITY

  Electrospraying/electrospinning of poly(γ-stearyl-L-glutamate) (PSLG) was investigated on a series solutions with different concentrations in chloroform. Field emission scanning electron microscopy (FESEM) and attenuated total reflectance Fourier transform infrared spectroscopy (FT-IR/ATR) were used to characterize the morphology and structure of the electrosprayed/electrospun polypeptide mats. It was found that electrospraying of PSLG with concentrations lower than 16 wt% afforded beads, while microfibers could be electrospun at the concentration of 22 wt%. The hydrophobicity of the electrosprayed/electrospun PSLG mats was investigated with static water contact angle (WCA) and tilt angle measurements. It was demonstrated that the superhydrophobic surfaces of PSLG with WCAs and tilt angles in the ranges of 150°-170° and 16.5°-4.2°, respectively, were obtained through electrospraying/electrospinning process.     

低温和低压下水热合成Na4Zr2(SiO4)3

以ZrOCl_2·8H_2O,Na_2SiO_3·9H_2O和NaOH为原料,在250℃约100bar的条件下,水热晶化合成出Na_4Zr_2(SiO_4)_3,并生长相应的单晶。讨论了水热反应及其条件.产物借助于XRD,Raman,~(29)Si MAS NMR以及阻抗谱技术进行了研究.结果表明产物具有与其他方法制备的Na_4Zr_2(SiO_4)_3相同的性质.     

Immobilization of glucose oxidase with the blend of regenerated silk fibroin and poly(vinyl alcohol) and its application to a 1,1′- dimethylferrocene-mediating glucose sensor

The structure and properties of the blend of regenerated silk fibroin (RSF) and poly(vinyl alcohol) (PVA) were investigated. The two polymers in the blend are in the state of phase segregation. Infrared (IR) spectra indicate that the RSF in the blend maintains its intrinsic properties, thus, ethanol treatment can transfer silk I structure of RSF to silk II structure. The water absorption property and mechanical property of the blend are improved in comparison with those of RSF. The blend maintains the major merit of RSF, that is, it can immobilize glucose oxidase on the basis of the conformational transition from silk I structure to silk II structure. The properties of the immobilized enzyme are examined. Moreover, the second generation of glucose sensor based on the immobilized enzyme is fabricated and it has a variety of advantages including easy maintenance of enzyme, simplicity of construction, fast response time and high stability.     

烟酸对酸性硫酸盐体系铜电沉积的影响

对溶液A: 0.8 mol•L－1硫酸铜,0.6 mol•L－1硫酸,5.0×10－5 mol•L－1氯离子,1.0×10－4 mol•L－1聚乙二醇的溶液,溶液B:在溶液A中加入2.0×10－2 mol•L－1烟酸,pH为0.5,运用循环伏安和计时安培法研究玻碳电极上铜的电沉积行为.结果表明,铜的电沉积过程经历了晶核形成过程,其电结晶按瞬时成核和三维生长方式进行.烟酸的加入对铜的电沉积具有阻化作用,但不改变铜的电结晶机理.沉积层的X射线衍射表明Cu为面心立方结构,在烟酸存在下沉积层出现(220)高择优取向,这可能是烟酸在Cu(220)晶面上发生强烈吸附作用的结果.     

介绍一个绿色物理化学实验——凝固点降低法测定葡萄糖的摩尔质量

以葡萄糖-水为体系对传统的凝固点降低法测定摩尔质量实验进行了改进,以低温小钢珠代替晶种,建立了一种控制过冷深度的有效方法;利用干燥的方法解决了葡萄糖样品中结晶水不确定的问题。     

Solvent extraction of uranium(VI) with benzyloctadecyldimethylammonium chloride (BODMAC) from highly concentrated chloride solution

The ²²²Rn emanation fraction (EF) released from the technically enhanced naturally occurring radioactive material (TE-NORM) wastes at certain sites of petroleum and gas production was determined. The samples were analyzed by γ-ray spectrometry to determine the activity concentration of the ²²⁶Ra content, of which the ²²²Rn emanation fraction was calculated. The results showed that the ²²²Rn emanation fraction differs in the oil and gas production sites and it is independent of the activity concentration of ²²⁶Ra. This revised version was published online in August 2006 with corrections to the Cover Date.     

Growth of porous single-crystal Cr2O3 in a 3-D mesopore system

Single-crystal Cr2O3 with regular mesopores has been synthesized using mesoporous silica KIT-6 as a template and characterized by using XRD, HRTEM and nitrogen adsorption/desorption.     

Dexmedetomidine promotes the progression of hepatocellular carcinoma through hepatic stellate cell activation

Dexmedetomidine (DEX) is an anesthetic that is widely used in the clinic, and it has been reported to exhibit paradoxical effects in the progression of multiple solid tumors. In this study, we sought to explore the mechanism by which DEX regulates hepatocellular carcinoma (HCC) progression underlying liver fibrosis. We determined the effects of DEX on tumor progression in an orthotopic HCC mouse model of fibrotic liver. A coculture system and a subcutaneous xenograft model involving coimplantation of mouse hepatoma cells (H22) and primary activated hepatic stellate cells (aHSCs) were used to study the effects of DEX on HCC progression. We found that in the preclinical mouse model of liver fibrosis, DEX treatment significantly shortened median survival time and promoted tumor growth, intrahepatic metastasis and pulmonary metastasis. The DEX receptor (ADRA2A) was mainly expressed in aHSCs but was barely detected in HCC cells. DEX dramatically reinforced HCC malignant behaviors in the presence of aHSCs in both the coculture system and the coimplantation mouse model, but DEX alone exerted no significant effects on the malignancy of HCC. Mechanistically, DEX induced IL-6 secretion from aHSCs and promoted HCC progression via STAT3 activation. Our findings provide evidence that the clinical application of DEX may cause undesirable side effects in HCC patients with liver fibrosis.Subject terms: Cancer microenvironment, Cell growth     

Separation of Sulfonylurea Herbicides and Determination of Bensulfuron-methyl Residues in Tapwater by HPTLC

JPC – Journal of Planar Chromatography – Modern TLC - In this work we have studied the separation of a mixture of the sulfonylurea herbicides (metsulfuron-methyl, chlorsulfuron,...