The role of mitochondrial DNA mutation on neurodegenerative diseases

Many researchers have reported that oxidative damage to mitochondrial DNA (mtDNA) is increased in several age-related disorders. Damage to mitochondrial constituents and mtDNA can generate additional mitochondrial dysfunction that may result in greater reactive oxygen species production, triggering a circular chain of events. However, the mechanisms underlying this vicious cycle have yet to be fully investigated. In this review, we summarize the relationship of oxidative stress-induced mitochondrial dysfunction with mtDNA mutation in neurodegenerative disorders.     

Nilpotent Orbits in the Witt Algebra W 1

In this article, the nilpotent orbits of the Witt algebra W ₁ are determined under the automorphism group over an algebraically closed field F of characteristic p > 3. In contrast with a finite number of nilpotent orbits in a classical simple Lie algebra (cf. [5 Jantzen , J. C. ( 2003 ). Nilpotent orbits in representation theory . Progr. Math. 1 – 211 . [Google Scholar]]), there is an infinite number of nilpotent orbits in W ₁. A set of representatives of nilpotent orbits, as well as their dimensions, are precisely presented.     

放射金属组学：以α核素靶向治疗药物为例

金属组学是综合研究生命体内(特别是细胞内)自由或络合的全部金属和类金属的含量、分布、形态、结构及功能的一门学科。作为金属组学的一个分支,放射金属组学重点研究放射性核素的制备和应用,特别是其在环境和生物体内的含量、分布、化学种态及功能等。靶向α治疗(Targeted alpha therapy, TAT)是一种利用发射α粒子的放射性核素与肿瘤选择性载体分子结合实现靶向癌细胞,进而对肿瘤组织造成杀伤作用的一种医疗方法,是放射金属组学在癌症治疗领域的重要应用方向。α粒子凭借高线性能量传递、短组织射程和较强的相对生物学效应,在放射性免疫和肿瘤治疗方面有着广阔的应用前景。以TAT药物为例,就常用α核素、TAT药物螯合剂及其标记的靶向载体、几种重要α放射性核素靶向治疗进展予以综述,并分析TAT药物研发的挑战和发展前景,从而展示放射金属组学在核医学领域特别是癌症治疗领域的研究进展。随着更多α核素的制备和更多靶向标记方法的建立,TAT药物有望用于多种疾病,这也需要新的放射金属组学方法的建立和应用。因此,放射金属组学在核医学领域具有良好应用前景。     

基于静电喷射法活性多孔磁性炭球的制备及其对亚甲基蓝的吸附

在利用静电喷射一步法获得壳聚糖(CS)磁性微球(Fe₃O₄/CS)的基础上,对Fe₃O₄/CS进行高温炭化和碱活化处理获得活性磁性多孔炭球(A-Fe₃O₄/C),并对A-Fe₃O₄/C吸附水中亚甲基蓝(MB)分子的性能进行了研究。在利用扫描电子显微镜、红外吸收光谱仪、比表面分析仪对制备微球的形貌和结构进行分析的基础上,深入研究溶液pH、吸附时间、温度以及活化剂种类等因素对A-Fe₃O₄/C吸附性能的影响。研究结果表明,A-Fe₃O₄/C对MB的吸附量随着pH值的增加而增大,且经KOH活化后的A-Fe₃O₄/C对MB表现出较优的吸附性能。A-Fe₃O₄/C对MB的吸附过程符合伪二级动力学方程和Langmuir等温线模型,理论最大吸附容量可达300.6 mg·g^-1。此外,A-Fe₃O₄/C表现出良好的重复利用性能,6次循环后对MB的去除率没有明显下降。     

Character Formulas for a Class of Simple Restricted Modules over the Simple Lie Superalgebras of Witt Type

Let F be an algebraically closed field of prime characteristic, and W(m, n, 1) be the simple restricted Lie superalgebra of Witt type over F, which is the Lie superalgebra of superderivations of the superalgebra ■(m; 1) ■∧(n), where ■(m; 1) is the truncated polynomial algebra with m indeterminants and ∧(n) is the Grassmann algebra with n indeterminants. In this paper, the author determines the character formulas for a class of simple restricted modules of W(m, n, 1) with atypical weights of type...     

声速测量中换能晶片的反射对超声脉冲时延的影响

超声传播速度和衰减值的测量,作为超声基本量的测量和超声技术的一些应用,都有着重要的意义。多次脉冲反射法是目前超声测声速、声衰减等工作中最常用的方法,尤其对体积不大的固体材料的测量中,用得更多。用这类方法测声速时,都需要测定超声脉冲在被测样块内在返一次所经历的时间。而对这一时延值的确定,目前来说,有着两种方案,即当超声脉冲往返一次反射后,或者依据它的包络的相应时延直接确定;或者依据它的射频相位的比较来推算确定。前者测量方法和设备较简单,后者测量结果的精度较高。     

Two Types of New Solutions to KdV Equation

It is common knowledge that the soliton solutions u（x, t） defined by the bell-shape form is required to satisfy the following condition lira u（x, t） = u（±∞, t） = 0. However, we think that the above condition can be modified as lim u（x, t） = u（±∞, t）^x→ = c, where c is a constant, which is called as a stationary height of u（x, t） in the present paper.^x→∞ If u（x, t） is a bell-shape solitary solution, then the stationary height of each solitary wave is just c. Under the constraint c = 0, all the solitary waves coming from the N-bell-shape-sollton solutions of the KdV equation are the same-oriented travelling. A new type of N-soliton solution with the bell shape is obtained in the paper, whose stationary height is an arbitrary constant c. Taking c ≥ 0, the resulting solitary wave is bound to be the same-oriented travelling. Otherwise, the resulting solitary wave may travel at the same orientation, and also at the opposite orientation. In addition, another type of singular rational travelling solution to the KdV equation is worked out.     

一类S-mKdV方程族及其扩展可积模型

由loop代数的一个子代数出发，构造了一个线性等谱问题，再利用屠格式计算出了一类Liouvelle意义下的可积系统及其双Hamilton结构，作为该可积系统的约化，得到了著名的Schrdinger方程和mKdV方程，因此称该系统为S-mKdV方程族.根据已构造的的子代数，又构造了维数为5的loop代数的一个新的子代数，由此出发设计了一个线性等谱形式，再利用屠格式求得了S-mKdV方程族的一类扩展可积模型.利用这种方法还可以求BPT方程族、TB方程族等谱系的扩展可积模型.因此本方法具有普遍应用价值.最后作为特例，求得了著名的Schrdinger方程和mKdV方程的可积耦合系统.     

Preparation of polymeric sheet porphyrin complexes and their environmentally benignly catalytic activity

The polymeric meso-tetra-(1,5-naphthalene bisulfonyloxo)phenylporphyrin and its complexes (PTNBSOPPM, M=Co, Mn, Fe) have been prepared in the presence of phase-transfer catalyst. Catalyzed by polymeric porphyrin complexes (PTNBSOPPM), styrene can be aerobic oxidized. The main products come from cleavage of double bond is in catalytic oxidation of styrene or α-methyl styrene.     

An information‐based burn‐in procedure for minimally repaired items from mixed population

Burn‐in is a method used to eliminate the initial failures in field use. In this paper, we will consider an information‐based burn‐in procedure for repairable items, which is completely new type of burn‐in procedure. By this procedure, based on the operational (failure and repair) history of the items observed during burn‐in procedure, those with poor reliability performance are eliminated. From a probabilistic point of view, this burn‐in procedure utilizes the information contained in the ‘random paths’ of the corresponding point processes. A general formulation of the model will be suggested, and under the suggested framework, two‐stage optimization procedure for determining optimal burn‐in procedures will be studied in detail. Copyright © 2016 John Wiley & Sons, Ltd.