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141.
6A,6X-Dideoxy-6A-phenylthio-6X-[(β-naphthylsulfonyl)oxyl]-β-cyclodextrins (X=G and B) (5 and 6) were prepared together with the other isomers (X=C, D, E, and F) (1–4), isolated by reversed-phase column chromatography, and structurally assigned by use of Taka amylolysis. 相似文献
142.
Hakogi T Monden Y Taichi M Iwama S Fujii S Ikeda K Katsumura S 《The Journal of organic chemistry》2002,67(14):4839-4846
The highly efficient and stereocontrolled syntheses of sphingomyelin carbon analogues 1 and 2 were achieved by effectively utilizing Hofmann rearrangement of enantiomerically pure beta-hydroxyamide 7, which was prepared by an asymmetric hydrogenation of alpha-acyl-gamma-butyrolactone 9 and ring opening with NH(3). Intermediary isocyanate 6 was selectively trapped with the vicinal hydroxy group in an intramolecular fashion to produce an oxazolidinone derivative, 5. In the synthesis of a quite polar compound such as 1, a convenient one-pot procedure of the introduction of a benzyloxycarbonyl group into the hydroxy group resulting from the oxazolidinone ring opening is another key point, because, in addition to the efficiency, this protecting group was easily removable by a simple procedure and workup at the final step. Both synthesized compounds 1 and 2 showed moderate inhibitory activity toward sphingomyelinase from B. cereus. 相似文献
143.
Nakane T Maeda Y Ebihara H Arai Y Masuda K Takano A Ageta H Shiojima K Cai SQ Abdel-Halim OB 《Chemical & pharmaceutical bulletin》2002,50(9):1273-1275
Two new migrated hopane triterpenoids, viz. 4alpha-hydroxyfilican-3-one and fern-9(11)-en-12beta-ol, and olean-18-en-3-one and olean-12-en-3-one as the first example of oleanane compounds from Adiantum ferns were isolated along with many other known triterpenoids from Adiantum capillus-veneris of China and Egypt. Their structures were elucidated by spectroscopic analyses. 相似文献
144.
The Gaussian-type basis sets for molecular calculations are usually prepared by an atomic SCF program in which spherical coordinates are used. On the other hand, many molecular SCF and CI programs are written by using the Cartesian coordinates and as a result six-membered d-type functions (x2, y2, z2, xy, yz, zx)e?γr2 are often used. They contain one additional 3s function which does not exist in the atomic calculation. Therefore, we shall have an incorrect, deeper molecular binding energy, unless we readjust the atomic total energy by adding the 3s orbital to the original basis set. Some examples are shown in the case of Cu2 molecule, where we have found that the correction is quite appreciable, which was overlooked in previous work. 相似文献
145.
Hiroyasu Nishiguchi Shuji Kimura Tatsumi Ishihara Yusaku Takita 《Research on Chemical Intermediates》1998,24(4):391-399
Cu ion-exchanged SAPO-34 which is a highly active catalyst for selective reduction of NO with C3H6, was synthesized and the Cu ion was characterized in the SAPO-34 by ESR, XPS, IR, and XAFS. ESR study indicated that two
kinds of Cu(II) with different environments exist in SAPO-34. The Cu(II) species disappeared immediately by C3H6 treatment and recovered by oxygen treatment. XAFS study indicated that most of the Cu(II) was reduced to Cu(I) under the
presence of C3H6.
These studies revealed that a selective NO reduction by C3H6 over SAPO-34 should proceed by the redox reaction of a copper ion between Cu(I) and Cu(II). 相似文献
146.
One-pot treatment of alkyl iodides, alpha,beta-unsaturated esters (or nitriles), and acylating agents such as nitriles or acid anhydrides in the presence of Zn metal at room temperature in the same reaction system brought about a regioselective and sequence-selective three-component joining reaction involving first C-alkylation at the beta-position and second C-acylation at the alpha-position of alpha,beta-unsaturated esters (or nitriles) to afford the corresponding alpha,alpha-dialkylketoesters (or alpha,alpha-dialkylketonitriles) in moderate to good yields. [reaction: see text] 相似文献
147.
[reaction: see text] Electroreduction of styrenes or alkyl methacrylates in the presence of aliphatic acid anhydrides or N-acylimidazoles with an undivided cell equipped with zinc electrodes as the anode and the cathode brought about novel one-pot vicinal double C-acylation to afford the corresponding 1,4-diketones in satisfactory yields. 相似文献
148.
Yoshiro Nakamura Kunio Mori Kosaku Tamura Yoshiko Saito 《Journal of polymer science. Part A, Polymer chemistry》1969,7(11):3089-3100
Forty polycyanurates were prepared by the interfacial polycondensation of 2-substituted 4,6-dichloro-s-triazines with various aromatic diols. Nitrobenzene was used as a solvent, aqueous sodium hydroxide as an acid acceptor, and a cationic emulsifier as an accelerator. The rate of reaction was largely increased by ultrasonic irradiation. The polymer yield was in the range 57–91%, and the reduced viscosity was 0.41–3.5. The polymers were soluble in chloroform, nitrobenzene, and o-dichlorobenzene but insoluble in common organic solvents such as alcohol, acetone, and hydrocarbons. A clear film was obtained from the chloroform-soluble polymers after evaporation of the solvent. The softening temperature and the thermal stability of each polycyanurate was significantly related to the substituent on the s-triazine nucleus as well as to the diol component in the molecular chain. Polymers of favorable properties were derived from 2-substituted 4,6-dichloro-s-triazines with R = ? C6H5, ? N(C6H5)2, ? N(C6H11)2, ? N(C6H5)(SO2C6H4CH3), or carbazyl and aromatic diols such as 4,4′-dihydroxybenzophenone, Bisphenol A, or phenolphthalein. These polymers showed tensile strength of 500–670 kg/cm2, elongation at break of 2.9–6.0%, and a minor weight loss at 300–350°C. 相似文献
149.
We developed a simple HPLC method for the simultaneous determination of lopinavir (LPV), ritonavir (RTV) and efavirenz (EFV) to evaluate the efficiency of co-administration of LPV/RTV and EFV in Japanese patients enrolled in a clinical study. The monitoring of LPV plasma concentration is important because co-administration of LPV/RTV with EFV sometimes decreases plasma concentrations of LPV caused by EFV activation of cytochrome P-450 3A. A solution of acetonitrile, methanol and tetramethylammonium perchlorate (TMAP) in dilute aqueous trifluoroacetic acid (TFA) has been used as the mobile phase in a HPLC method to elute LPV and RTV. We found that a solvent ratio of 45 : 5 : 50 (v/v/v) of acetonitrile/methanol/0.02 M TMAP in 0.2% TFA optimized separation of LPV, RTV and EFV. A column temperature of 30 degrees C was necessary for the reproducibility of the analyses. Standard curves were linear in the range 0.060 to 24.06 micro g/ml for LPV, 0.010 to 4.16 micro g/ml for RTV, and 0.047 to 37.44 micro g/ml for EFV. Coefficients of variation (CVs) of LPV, RTV and EFV in intraday and interday assays ranged from 1.5 to 4.0%, 2.5 to 16.8% and 1.0 to 7.7%, respectively. Accuracies ranged from 100 to 110%, 101 to 116% and 99 to 106% for LPV, RTV and EFV, respectively. The extraction recoveries were 77-87, 77-83 and 81-91% for LPV, RTV and EFV, respectively. 相似文献
150.
Yoshiko Miura 《Journal of polymer science. Part A, Polymer chemistry》2007,45(22):5031-5036
Saccharides on the cell surfaces participate in a number of biochemical phenomena via the protein–saccharide interaction. Synthetic glycopolymers mimic the function of the cell‐surface saccharides and efficiently interact with proteins, cells, and pathogens based on the multivalent effect. Since the biological functions of saccharides are paid much attention, the glycopolymers are being increasingly explored as biomaterials for medicinal application and tissue engineering. This review presents a practical approach of glycopolymers. The glycopolymers were prepared by the facile syntheses of poly(vinyl saccharide)s and the physical and biological properties were introduced. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 5031–5036, 2007 相似文献