Highly stereoselective construction of tetrahydroquinolines via cascade aza-Michael-Michael reaction: Formal [4+2] cycloaddition of β,γ-unsaturated α-ketoesters with 2-aminochalcones

An efficient cascade aza-Michael-Michael sequence for the preparation of tetrahydroquinolines has been established. Three contiguous stereogenic centers are created with high levels of enantioselectivities (79–99% ee) and exclusive diastereoselectivities in the presence of a bifunctional squaramide. This approach is compatible with a broad range of β,γ-unsaturated α-ketoesters and 2-aminochalcones. Our protocol indicated that β-site of β,γ-unsaturated α-ketoester is an available pro-nucleophilic site.     

基于离子交换和表面引发接枝聚合制备阴离子表面印迹材料及其识别特性研究

建立了一种新的离子表面印迹(IIP)方法. 使用偶联剂γ-氨丙基三甲氧基硅烷(AMPS)对微米级硅胶微粒进行表面改性, 制得表面含有氨基的改性硅胶AMPS-SiO₂. 凭借离子交换作用, 阳离子单体甲基丙烯酰氧乙基三甲基氯化铵(DMC)结合在模板离子磷酸根周围; 改性硅胶AMPS-SiO₂表面的氨基与溶液中的过硫酸盐构成氧化还原引发体系, 使DMC及交联剂N,N'-亚甲基双丙烯酰胺(MBA)在硅胶微粒表面发生接枝交联聚合, 从而实现了磷酸根离子的表面印迹, 制得了阴离子表面印迹材料IIP-PDMC/SiO₂. 采用静态与动态两种方法, 考察研究了IIP-PDMC/SiO₂对PO₄^3-离子的识别特性与结合性能. 研究结果表明, 离子表面印迹材料IIP-PDMC/SiO₂对PO₄^3-离子具有特异的识别选择性与优良的结合亲和性, 相对于对比离子高锰酸根离子, IIP-PDMC/SiO₂对PO₄^3-离子的识别选择性系数为9.58.     

Double Michael addition of nitromethane to divinyl ketones: A remarkably positive effect of additive

An efficient double Michael addition of nitromethane to divinyl ketones was established in good to high yields (75–99%). A wide range of cyclohexanones were obtained with excellent diastereocontrol (up to >20:1 dr) and enantioinduction (91–99% ee) in a one-pot fashion. The involvement of basic additive significantly enhanced the reactivity of this cascade sequence.     

THE RELATION BETWEEN STRENGTH AND RIGIDITY OF BEAM1)

本文提出了梁的强刚比的定义,用无量纲的形式定量地表达了梁的强度与刚度之间的关系,以期充分发挥材料的潜力并促进材料力学的课堂教学。强刚比与载荷大小无关,其数值可以通过有限元方法或者通过梁的载荷试验来获得。结合工程实际,从设计和试验两个方面对梁的强刚比 及其影响因素进行了简要地探讨和分析。     

Preparation of free-standing nanowire arrays on conductive substrates

By combining supercritical drying technique with AAO template-assisted electrodeposition, noncollapsed, vertically aligned, and free-standing nanowire arrays on a conductive Au film have been fabricated. We also demonstrate that these free-standing nanowire arrays can be feasibly used for fabricating nanowire-based electrically driven devices.     

非圆截面环流器FY-1实验(Ⅰ)——被动运行部分

本文简略地描述了FY-1装置结构、等离子体基本参数的测量和等离子体位形的调试,初步考察了硬X射线产额与工作气压的关系。实验分析表明,FY-1装置已形成的等离子体环流放电属于逃逸放电。在场成形线圈作被动运行时,通过改变其回路连接方式和外串电感值,可适当调节等离子体平衡位置和位形。MHD平衡计算与实验测量拟合结果表明,等离子体截面可调节为不同截面积和拉长比(k=1.1—1.4)的椭圆。     

Carbon cloth supported lithiophilic carbon nanotubes@Ag skeleton for lithium anode via ultrafast Joule heating method

Journal of Solid State Electrochemistry - Regulating lithium deposition and stripping behavior during cycles is critical for constructing high-performance and stable lithium metal anodes (LMAs)....     

Bacterial Cytochrome P450 Catalyzed Post-translational Macrocyclization of Ribosomal Peptides**

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a fascinating group of natural products that exhibit diverse structural features and bioactivities. P450-catalyzed RiPPs stand out as a unique but underexplored family. Herein, we introduce a rule-based genome mining strategy that harnesses the intrinsic biosynthetic principles of RiPPs, including the co-occurrence and co-conservation of precursors and P450s and interactions between them, successfully facilitating the identification of diverse P450-catalyzed RiPPs. Intensive BGC characterization revealed four new P450s, KstB, ScnB, MciB, and SgrB, that can catalyze the formation of Trp-Trp-Tyr (one C−C and two C−N bonds), Tyr-Trp (C−C bond), Trp-Trp (C−N bond), and His-His (ether bond) crosslinks, respectively, within three or four residues. KstB, ScnB, and MciB could accept non-native precursors, suggesting they could be promising starting templates for bioengineering to construct macrocycles. Our study highlights the potential of P450s to expand the chemical diversity of strained macrocyclic peptides and the range of biocatalytic tools available for peptide macrocyclization.     

岩石爆破破碎时间及微差起爆延时优化

利用分形理论分析岩石爆破的破碎时间，提出了岩石爆破破碎时间的计算方法和微差起爆延时优化的一种途径。