2-[(卤代苯胺基)羰基]苯甲酸与Cu(Ⅱ)、Ni(Ⅱ)、Co(Ⅱ)的配合物研究

本文报道了4种2-[(卤代苯胺基)羰基]苯甲酸与Cu(Ⅱ)、Ni(Ⅱ)、Co(Ⅱ)配合物的制备,并通过元素分析、热重分析、红外光谱和电子光谱分析以及磁化率测定对它们进行了表征.结果证明,配合物是通过羧酸根上羟基氧原子和酰胺羰基上氧原子配位成键,除Cu(Ⅱ)配合物分子为平面正方形结构外.其余均为八面体结构,只是扭曲程度不同.并对它们的配位场参数进行了计算.     

液相色谱法分离金属螯合物的进展

综述了用薄层液相色谱法和柱液相色谱法分离金属螯合物的进展及其在金属离子分析方面的应用。     

Development of a Fully Continuous-Flow Approach Towards Asymmetric Total Synthesis of Tetrahydroprotoberberine Natural Alkaloids

Continuous flow synthetic technologies had been widely applied in the total synthesis in the past few decades. Fully continuous flow synthesis is still extremely focused on multi-step synthesis of complex natural pharmaceutical molecules. Thus, the development of fully continuous flow total synthesis of natural products is in demand but challenging. Herein, we demonstrated the first fully continuous flow approach towards asymmetric total synthesis of natural tetrahydroprotoberberine alkaloids, (−)-isocanadine, (−)-tetrahydropseudocoptisine, (−)-stylopine and (−)-nandinine. This method features a concise linear sequence involving four chemical transformations and three on-line work-up processing in an integrated flow platform, without any intermediate purification. The overall yield and enantioselectivity of this four-step continuous flow chemistry were up to 50 % and 92 %ee, respectively, in a total residence time of 32.5 min, corresponding to a throughput of 145 mg/h.     

2-甲氧基烟酸嘧霉胺盐晶体结构的研究

由嘧霉胺和2-甲氧基烟酸在乙醇介质中反应制得了化合物2-甲氧基烟酸嘧霉胺盐,经确证其晶体属于单斜晶系,空间群为P2(1)/n,a=1·0102(1)nm,b=0·7602(1)nm,c=2·3178(2)nm,β=96·74(2)°,V=1·7677(3)nm3,Dc=1·324g/cm3,Z=4,F(000)=744,μ=0·092mm-1,线性吸收系数μ(MoKα)=0·072mm-1。晶胞中不含结晶水,也不含配位水。每一个结构单元中有两个氢键,2-甲氧基烟酸嘧霉胺盐中不存在分子间氢键,主要靠范德华力在空间形成三维无限堆积结构。     

论化学学习中科学美感的产生和作用

科学美感的培养是理科教学中普遍面临的新课题。本文以“科学美实质是情感与事物内形式所建构的和谐关系”为基本观点,从学习论角度对化学学习中科学美感的产生及其在创新学习中的作用进行了较为深入的探讨。     

Fabrication of Superoxide Dismutase (SOD) Imprinted Poly(ionic liquid)s via eATRP and its Application in Electrochemical Sensor

Superoxide dismutase (SOD) plays an important role in nearly all living cells. In this study, SOD imprinted poly(ionic liquid)s (SIPILs) were prepared on the surface of the bare Au electrode modified with nano‐palladium and nano‐gold (Au/nPd/nAu/SIPILs). SIPILs was synthesized with 1‐vinyl‐3‐propyl imidazole sulfonate ionic liquids as functional monomers via electrochemically mediated atom transfer radical polymerization (eATRP) catalyzed by SOD. The Au/nPd/nAu/SIPILs was examined by cyclic voltammetry (CV), scanning electron microscope (SEM), energy‐dispersive spectrometer (EDS) and X‐ray photoelectron spectroscopy (XPS). The Au/nPd/nAu/SIPILs was also used as an electrochemical sensor to determine SOD by differential pulse voltammetry (DPV). Under the optimal conditions, the detection range of SOD was from 1.0×10^?8 to 1.0×10² mg L^?1 with a limit of detection of 8.90×10^?9 mg L^?1 (S/N=3). Compared with other methods, the sensor based on SIPILs had the broader linear range and lower detection limit.     

YL－110型流动注射测金装置的研制

研制了一台流动注射测金装置。该装置由一台四道蠕动泵、两支旋转阀，一支８５３１纤维分离富集柱和有关电路组成一个整体，靠蠕动泵自动输送试样溶液，酸洗液和金洗脱液，使金在Φ３×４０ｍｍ的微型纤维柱上富集，由控制电路控制旋转阀切换自动完成柱平衡，进样，洗涤，洗脱过程，金洗脱液自动送入原子吸收分光光度计测定金。８５３１纤维是金的良好吸附剂，具有选择性容量大的优点。试样经王水分解后可直接进样测定。该装置与原子吸收分光光度计联用测定金。金的特征浓度可达０．６ｎｇ／ｍＬ每小时可测定４０～６０次。用本装置分析０．１６μｇ／ｍＬ金溶液，ＲＳＤ为０．８％。用于分析化探样品，铜精矿，电解铜等试样中金，得到满意的结果。     

溶菌酶响应纳米钻石载药体系制备及其与HepG2细胞作用

通过缩水甘油(GLY)与阿霉素(DOX)发生开环反应,赋予阿霉素活性羟基基团,以氨基己酸(ACA)为桥梁,通过共价键合方法将缩水甘油化阿霉素(GLY-DOX,GDOX)偶联于氨基己酸化纳米钻石(ND-ACA)载体上,获得具有溶菌酶响应特性的ND-ACA-GLY-DOX(NAGD)药物输送体系。 采用荧光光谱法测定了ND表面偶联ACA和DOX的量分别为(185±10.0) μg/mg和(115±5.2) μg/mg。 体外释药发现NAGD在生理环境(pH=7.4)中药物释放量很低,而在肿瘤细胞溶酶体环境中(溶菌酶存在下),酯键水解断裂,大量释放DOX。 以肝癌细胞HepG2为模型,采用细胞形态测试法表明NAGD可有效杀死肿瘤细胞。 上述研究结果表明,NAGD可作为一种良好的药物输送体系,并为共价偶联药物开拓新思维。