Nickel-catalyzed cross-electrophile allylation of vinyl bromides and the modification of anti-tumour natural medicine β-elemene

Herein, we present a facile and efficient allylation method via Ni-catalyzed cross-electrophile coupling of readily available allylic acetates with a variety of substituted alkenyl bromides using zinc as the terminal reductant. This Ni-catalyzed modular approach displays excellent functional group tolerance and a broad substrate scope, which the creation of a series of 1,4-dienes including several structurally complex natural products and pharmaceutical motifs. Moreover, the coupling strategy has the potential to realize enantiomeric control. The practicality of this transformation is demonstrated through the potent modification of the naturally antitumor active molecule β-elemene.

Herein, we present a facile and efficient allylation method via Ni-catalyzed cross-electrophile coupling of readily available allylic acetates with a variety of substituted alkenyl bromides using zinc as the terminal reductant.     

Three-Way Decision Models Based on Ideal Relations in Multi-Attribute Decision-Making

In recent years, research on applications of three-way decision (e.g., TWD) has attracted the attention of many scholars. In this paper, we combine TWD with multi-attribute decision-making (MADM). First, we utilize the essential idea of TOPSIS in MADM theory to propose a pair of new ideal relation models based on TWD, namely, the three-way ideal superiority model and the three-way ideal inferiority model. Second, in order to reduce errors caused by the subjectivity of decision-makers, we develop two new methods to calculate the state sets for the two proposed ideal relation models. Third, we employ aggregate relative loss functions to calculate the thresholds of each object, divide all objects into three different territories and sort all objects. Then, we use a concrete example of building appearance selection to verify the rationality and feasibility of our proposed models. Furthermore, we apply comparative analysis, Spearman’s rank correlation analysis and experiment analysis to illustrate the consistency and superiority of our methods.     

Synthesis, Structure and H+/K+-ATPase Inhibitory Activity of Novel Triazolyl Substituted Tetrahydrobenzofuran Derivatives via One-pot Three-component Click Reaction

Eleven triazolyl substituted tetrahydrobenzofuran derivatives were synthesized in high yields as novel H⁺/K⁺‐ATPase inhibitor via one‐pot CuI‐catalyzed three‐component click reaction of azide, secondary amine and 3‐bromopropyne under mild conditions in water. Their structures were characterized by NMR, IR, ESI‐MS, elemental analysis and single‐crystal X‐ray diffraction analysis. Most of the target compounds exhibited better H⁺/K⁺‐ATPase inhibitory activity than commercial omeprazole with IC₅₀ values less than 15 µmol·L^?1. The initial structure‐activity analysis suggested that the triazole substituted by cycloalkyl, aromatic ring or O‐containing side‐chain seemed to be beneficial for enhancing the activity.     

Pyrrole alkaloids from <Emphasis Type=Italic>Alhagi sparsifolia</Emphasis>

The novel pyrrole alkaloid alhagifoline A (1) together with the two known analogs pyrrolezanthine (2) and pyrrolezanthine-6-methyl ether (3) were isolated from the aerial part of Alhagi sparsifolia. Their structures were established based on spectral (HR-ESI-MS, ¹ H and ¹³C NMR, ¹ H–¹ H COSY, HSQC, HMBC) data. Compounds 2 and 3 were isolated from the genus Alhagi for the first time.     

Nanoscale Broadband Viscoelastic Spectroscopy of Soft Materials Using Iterative Control

A novel approach to nanoscale broadband viscoelastic spectroscopy is presented. The proposed approach utilizes the recently developed modeling-free inversion-based iterative control (MIIC) technique to achieve accurate measurement of the material response to the applied excitation force over a broad frequency band. Scanning probe microscope (SPM) and nanoindenter have become enabling tools to quantitatively measure the mechanical properties of a wide variety of materials at nanoscale. Current nanomechanical measurement, however, is limited by the slow measurement speed: the nanomechanical measurement is slow and narrow-banded and thus not capable of measuring rate-dependent phenomena of materials. As a result, large measurement (temporal) errors are generated when material is undergoing dynamic evolution during the measurement. The low-speed operation of SPM is due to the inability of current approaches to (1) rapidly excite the broadband nanomechanical behavior of materials, and (2) compensate for the convolution of the hardware adverse effects with the material response during high-speed measurements. These adverse effects include the hysteresis of the piezo actuator (used to position the probe relative to the sample); the vibrational dynamics of the piezo actuator and the cantilever along with the related mechanical mounting; and the dynamics uncertainties caused by the probe variation and the operation condition. In the proposed approach, an input force signal with frequency characteristics of band-limited white-noise is utilized to rapidly excite the nanomechanical response of materials over a broad frequency range. The MIIC technique is used to compensate for the hardware adverse effects, thereby allowing the precise application of such an excitation force and measurement of the material response (to the applied force). The proposed approach is illustrated by implementing it to measure the frequency-dependent plane-strain modulus of poly(dimethylsiloxane) (PDMS) over a broad frequency range extending over 3 orders of magnitude (~1 Hz to 4.5 kHz).     

HT—6M闭环反馈平衡控制系统

本文描述HT-6M托卡马克装置闭环反馈平衡控制系统的结构组成,通过对各个环节的简化,得到了有效实用的数学模型,进而分析了系统稳态和动态性能。实验结果表明,该系统运行可靠;并且,将等离子体环水平位移控制在2mm以内。     

液态铅的电阻率

采用精确的结构因数实验数据和Ｂｅｈａｖｉ模型赝势，用Ｚｉｍａｎ理论计算了液态铅的电阻率．计算结果和实验数据符合很好．讨论了Ｚｉｍａｎ理论对液态铅的适用性以及适合于液态铅的赝势的特征．     

黄铜选择性溶解固相扩散机理的研究

采用恒电位暂态和旋转盘环电极等方法研究了α、α＋β以及β黄铜在硫酸钠、硫酸以及氯化钠的稀溶液中的阳极溶解过程．结果表明，在黄铜阳极溶解的初始阶段测得的ｉ－ｔ曲线遵循抛物线定律，求得ｉ－ｔ为一通过坐标原点的直线，证明了黄铜中锌的选择性溶解受固相扩散控制，计算出在上述溶液中黄铜中锌的扩散系数值在１０－１５～１０－１３ｃｍ２·ｓ－１数量级，介质成分和微量合金元素砷对扩散系数值有明显的影响．     

光热敏折变玻璃及其布拉格体光栅特性研究

采用高温二次化料的方法制备了一种SiO2-Al2O3-ZnO-Na2O(F、Br)玻璃体系的光热敏折变(PTR)玻璃,通过紫外曝光、透射率光谱、X射线衍射(XRD)和差热分析等方法研究了其光热敏析晶机理。研究表明,PTR玻璃的光敏区为280～350nm,工作区为400～2700nm,最佳成核温度和析晶温度分别为490℃和595℃,析晶组分为NaF晶体。采用双光束干涉方法与"两步法"的热处理工艺在PTR玻璃中制备了周期为1000mm-1的布拉格体光栅,光栅的相对衍射效率达到91%,并验证了制备的布拉格体光栅具有角选择滤波能力。     

Experiments and analysis of thin tungsten slice and W/Cu brazing for primary collimator scraper in CSNS/RCS

According to the requirements for the beam collimation system of the rapid cycling synchrotron(RCS)of China Spallation Neutron Source(CSNS),the main structure of a scraper of primary collimator is made by W/Cu brazing,in which the thickness of tungsten slice is 0.17 mm.In order to get the best mechanical properties,the brazing temperature is suggested to be controlled under the recrystallization temperature of tungsten,while the recrystallization temperature is affected directly by the thickness of tungsten.Because of little research and application on the brazing of thin tungsten slice of 0.17 mm and copper,tensile tests are done to get the mechanical properties of tungsten slices which experience different brazing temperatures.In keeping the inner relationships between the mechanical properties and temperature,another experiment is done by using SEM to scan the microstructures including the size and distribution of crystals.Finally we determine the recrystallization temperature of tungsten slice of 0.17 mm,and get the best parameters of W/Cu brazing for scrapers of primary collimator in CSNS/RCS.