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151.
An efficient palladium-catalyzed amination of aromatic bromides with hindered N-alkyl-substituted anilines is described, either using the combination of Pd(OAc)(2) and P(t-Bu)(3) or a palladium(I) tri-tert-butylphosphine bromide dimer, [Pd(mu-Br)(t-Bu(3)P)](2), a new, commercially available, and easily handled catalyst. 相似文献
152.
Samuel K Yin W Stearns RA Tang YS Chaudhary AG Jewell JP Lanza T Lin LS Hagmann WK Evans DC Kumar S 《Journal of mass spectrometry : JMS》2003,38(2):211-221
Metabolic activation of drug candidates to electrophilic reactive metabolites that can covalently modify cellular macromolecules may result in acute and/or idiosyncratic immune system-mediated toxicities in humans. This presents a significant potential liability for the future development of these compounds as safe therapeutic agents. We present here an example of an approach where sites of metabolic activation within a new drug candidate series were rapidly identified using online liquid chromatography/multi-stage mass spectrometry on an ion trap mass spectrometer. This was accomplished by trapping the reactive intermediates formed upon incubation of compounds with rat and human liver microsomes as their corresponding glutathione conjugates and mass spectral characterization of these thiol adducts. Based on the structures of the GSH adducts identified, potential sites and mechanisms of bioactivation within the chemical structure were proposed. These metabolism studies were interfaced with iterative structural modifications of the chemical series in order to block these bioactivation sites within the molecule. This strategy led to a significant reduction in the propensity of the compounds to undergo metabolic activation as evidenced by reductions in the irreversible binding of radioactivity to liver microsomal material upon incubation of tritium-labeled compounds with this in vitro system. With the efficiency and throughput achievable with such an approach, it appears feasible to identify and address the metabolic activation potential of new drug leads during routine metabolite identification studies in an early drug discovery setting. 相似文献
153.
本文首次利用碳基钴簇合物PhPCo_3(CO)_9催化剂,在常压和-20℃-0℃,用苯乙烯和重氮乙酸乙酯进行环丙烷化反应,合成了菊酸酯,重氮乙酸乙酯可全部转化,酯的选择性可达85%。产物经减压分馏后,由IR和 ̄1HNMR分析,确证了产物为菊酸酯,表明了羰基钴簇合物对苯乙烯的环丙烷化反应有良好的催化性能,为四面体异核簇合物用于不对称催化反应打下了基础。 相似文献
154.
The piezoelectric quartz crystal (PQC) impedance technique was applied to monitor in situ generation and precipitation of the ferric hydroxide sol in aqueous solutions at 90 degrees C. Equivalent circuit parameters and resonant frequencies as well as the half-peak width of the electroacoustic conductance spectrum deltaf(G1/2) for the PQC resonance were obtained and analyzed. Three stages, sol generation and simultaneous adsorption, adsorption equilibrium, and precipitation of ferric hydroxide sol could be identified in the process of adding the ferric nitrate solution into the hot water. A scheme of two consecutive reactions occurring at the electrode/solution interface was used to analyze the adsorption kinetics of ferric hydroxide sol onto the Au electrode. In addition, the electrolyte-induced precipitation of the colloid was monitored and discussed. Temperature effect on the PQC resonance behavior in liquid was also investigated. Since the PQC impedance technique provides multidimensional piezoelectric information in situ, it is highly recommended for studying the process of sol-gel generation and precipitation. Copyright 2001 Academic Press. 相似文献
155.
Qing Qing Meng He Xiang Bai Feng Li Quan Rui Wang Feng Gang Tao 《中国化学快报》2007,18(7):785-787
A convenient synthetic pathway to 2-aryl-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[1,5-α]azepine derivatives 7 was developed. The synthesis was based on the cycloaddition of the 1,2,3,4-tetrahydronaphthalene a-acetoxy azo compounds 3 with Ar-CN in the presence of AlCl3 and the consecutive ring enlargement. 相似文献
156.
157.
Dr. Dingfeng Yang Junzhu Yang Xuejun Quan Bin Zhang Guoyu Wang Xu Lu Xiaoyuan Zhou 《Chemphyschem》2021,22(24):2579-2584
Understanding the correlation between crystal structure and thermal conductivity in semiconductors is very important for designing heat-transport-related devices, such as high-performance thermoelectric materials and heat dissipation in micro-nano-scale devices. In this work, the lattice thermal conductivity ( ) of the cage-like compounds Cu3VSe4 and Cu3NbSe4 was investigated by experimental measurements and first-principles calculations. The experimental of Cu3NbSe4 is approximately 25 % lower than that of Cu3VSe4 at 300 K. The relevant important physical parameters, including the sound velocity, heat capacity, weighted phonon phase space (W), and third-order force constants along with atomic mass were theoretically analyzed. It is found that W is the dominant parameter in determining the , and the other factors only play a minor role. The physical origin is the relatively “soft” lattice of Cu3NbSe4 with heavier atomic mass. This research provides deep insight into the correlation between the thermal conductivity and crystal structure and paves the way for discovering high-performance thermal management device and thermoelectric materials with intrinsically low . 相似文献
158.
LI Quan College of Chemistry Sichuan Normal University Chengdu China 《中国科学B辑(英文版)》2006,49(3):209-213
The study of the intermolecular interactions that drive the solvation of six-membered nitrogenated aromatic rings is of particular importance since they are known to constitute key building blocks of pro- teins and nucleotides[1―5]. The investigation of the 1:1 adduct of these molecules with water will be the first step in the understanding of such interactions. These molecules possess two different proton-acceptor sites: the ring π cloud and the lone pairs of electrons on the nitrogen atoms… 相似文献
159.
Eu1—xTbxBa2Cu3O7—δ中Tb离子价态的研究 总被引:1,自引:0,他引:1
研究了BaTbO_3、Tb_4O_7、TbFeO_3的Tb_(4d)XPS谱,找到了表征Tb~(3+)、Tb~(4+)的特征峰,得出的高、低结合能峰强之比与Tb~(4+)/Tb含量间的依赖关系,可用于确定Eu_(1-x)Tb_xBa_2Cu_3O_(7-δ)中“123”相的Tb离子混合价态,用常压高温烧结法,未能获得纯“123”单相,也不易获得纯利Tb~(3+)价态样品.在Eu_(1-x)Tb_xBa_2Cu_3O_(7-δ)中的Tb以Tb~(3+)、Tb~(4+)混合价态存在;当x=0.3时,Tb~(4+)/Tb=0.61.引入Tb~(4+)后“123”主相Cu(2)-O(2)平面上的O_(2p)空穴数降低,这是Tb~(4+)破坏超导电性的一种可能原因。 相似文献
160.
含间苯基聚芳醚酮的合成与性能研究 总被引:3,自引:0,他引:3
含间苯基聚芳醚酮的合成与性能研究林权,张万金,吴忠文,尹玖梅(吉林大学化学系,长春,130021)(中国科学院长春应用化学研究所)关键词聚芳醚酮,间苯基,熔点,结晶度聚芳醚酮作为一类耐高温特种工程塑料,由于具有优异的热、电、机械性能,已被广泛应用于电... 相似文献