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991.
By variational methods, for a kind of Webster scalar curvature problems on the CR sphere with cylindrically symmetric curvature, we construct some multi-peak solutions as the parameter is sufficiently small under certain assumptions. We also obtain the asymptotic behaviors of the solutions. 相似文献
992.
993.
Lei Li Guangyuan Wang Shanshan Wei Xilong Yan Ligong Chen 《Research on Chemical Intermediates》2013,39(2):615-620
A modified procedure for synthesis of the side chain of ceftazidime-activated thioester has been established. This key intermediate of ceftazidime was obtained by a more eco-friendly process than conventional methods, and the yield was much higher (up to 92.4 %). It was found that different organic bases (triethylamine or pyridine) used in this reaction had different effects. The reaction conditions were also optimized to make the route more competitive and suitable for large-scale industrial production. 相似文献
994.
995.
996.
Zhang Wenfan Liu Yan Cao Shengli Chen Jiahui Zhang Zexia Zhang Jiazhong 《Nonlinear dynamics》2017,90(3):1841-1850
Nonlinear Dynamics - The flow-induced vibration of two-dimensional wing coupled with two nonlinear energy sinks (NESs) under freestream is studied by numerical methods, and the relationship between... 相似文献
997.
998.
Dinuclear Cu(II) complexes based on p‐xylylene‐bridged bis(1,4,7‐triazacyclononane) ligands: Synthesis,characterization, DNA cleavage abilities and evaluation of superoxide dismutase‐ and catalase‐like activities
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Three new dinuclear Cu(II) complexes with the formulas [Cu2(pxdmbtacn)Cl4] ( 1 ), [Cu2(pxdmbtacn)Cl0.7(NO3)1.3(OH)2(H2O)1.3]?6H2O ( 2 ) and [Cu2(pxdiprbtacn)Cl4] ( 3 ) together with one previously reported complex, [Cu2(pxbtacn)Cl4] ( 4 ), were obtained from Cu(II) salts with three p‐xylylene‐bridged bis‐tacn ligands bearing pendant alkyl substituents or without pendant group. Complex 2 was structurally characterized as a centrosymmetric dinuclear molecule with each metal center being coordinated to some labile ligands in addition to one tacn ring. Based on the results of mass spectrometry and UV–visible spectroscopy, complexes 1 and 3 are capable of existing in aqueous solution as dinuclear species but 4 can partially form a dimer of the original dinuclear motif. Complexes 1 , 3 and 4 can all effectively cleave supercoiled DNA oxidatively in the presence of hydrogen peroxide. The superoxide dismutase (SOD) activities of 1 and 3 measured under physiological conditions are comparable to that of the native CuZnSOD enzyme but the enzymatic activity of 4 is about three‐ to fourfold lower. Furthermore, complexes 1 , 3 and 4 demonstrate moderate scavenging effect on hydrogen peroxide and their catalase activities are in the decreasing order of 3 > 1 > 4 . 相似文献
999.
Wen Qiang Du Ze Ming Rong Yan Liang Yong Wang Xin Yi Lu Yi Fan Wang Lian Hai Lu 《中国化学快报》2012,23(7):773-776
Selective hydrogenation of α, β-unsaturated aldehydes with modified Pd/C catalyst was developed.The reduction of C=O bond could be efficiently inhibited by the addition of carbonates,and high selectivity to the corresponding saturated aldehydes was achieved under mild conditions.This protocol provides an alternative for efficient preparation of saturated aldehydes. 相似文献
1000.
Development and validation of a UPLC‐MS/MS method for the determination of cucurbitacin B in rat plasma and application to a pharmacokinetic study
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Waiou Zhao Dahai Xu Weiwei Yan Yushi Wang Nan Zhang 《Biomedical chromatography : BMC》2016,30(4):503-507
Cucurbitacin B (CuB), one of the most abundant forms of cucurbitacins, is a promising natural anticancer drug candidate. Although the anticancer activity of CuB has been well demonstrated, information regarding the pharmacokinetics is limited. A rapid, selective and sensitive UPLC‐MS/MS for CuB was developed and validated using hemslecin A (HeA) as internal standard (IS). Plasma samples were pre‐treated by liquid–liquid extraction with dichloromethane. Separation was achieved on a reversed‐phase C18 column (50 × 4.6 mm, 5 µm) at 35°C using isocratic elution with water–methanol (25:75, v/v) at a flow rate of 0.3 mL/min. The analytes were monitored by a triple quadrupole tandem mass spectrometer with positive electrospray ionization mode. The calibration curve was linear (r > 0.995) in a concentration range of 0.3–100 ng/mL with a limit of quantification of 0.3 ng/mL. Intra‐ and inter‐day accuracy and precision were validated by percentage relative error and relative standard deviation, respectively, which were both lower than the limit of 15%. This assay was successfully applied to a pharmacokinetic study of CuB in Wistar rats. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献