交联聚磷酸酯的合成及其释药性能研究

以（ｉ－Ｂｕ）３Ａｌ为引发剂研究了２－氢－２－氧－１，３，２二氧五环磷酸酯，２－氢－２－氧－１，３，２－二氧六联药物载体，要用单层骨架片、双层骨架片和夹心片 药方式，对抗肿瘤药物５－氟尿嘧啶进行了控制释放，获得了较好的释药效果。     

邻羟基二苯甲酮类紫外吸收剂离解常数的测定

本工作对两种常见的商品紫外吸收剂——2-羟基-4-甲氧基二苯甲酮(UV-9)和2,4-二羟基二苯甲酮(UV-0)在基态和激发态时的离解常数进行了测定。对UV-0存在着反常的吸收强度和pH关系曲线作了合理的解释, 并结合测得的离解常数对上述紫外吸收剂耗失能量的机理进行了讨论。     

含噻二唑环苯甲酰脲化合物的合成及杀虫活性

用活性亚结构连接法设计合成了6个新的含1，3，4-噻二唑杂环苯甲酰脲类化合物，其结构经红外光谱、核磁氢谱、元素分析方法确证。同时对其杀虫活性进行了初步研究，发现该类化合物在普筛浓度下对淡色库蚊幼虫具有较好的杀虫活性。化合物Ⅲb(R1=Cl,R2=n-C5H11),Ⅲd(R1=CH3,R2=n-C5H11),Ⅲf(R1=2,6-difluoro,R2=-C5H11)在10mg/L浓度下对淡色库蚊幼虫的杀虫死亡率大于90％。     

Preparation and characterization of nitrogen-doped TiO2 photocatalyst in different acid environments

Nitrogen-doped TiO₂ powders were successfully prepared by a wet method, i.e., a micro-emulsion-hydrothermal method, in different acid environments. Several characterization techniques, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and UV-visible diffuse reflectance spectra, were combined to determine the crystal phase, concentration and chemical states of the nitrogen doped in TiO₂. The high photocatalytic activity of the nitrogen-doped TiO₂ was evaluated through the decomposition of rhodanmine B under visible light irradiation. It was suggested that the doped nitrogen formed oxynitride (NO) and produced impurity states at higher above the valence band of TiO₂. Therefore, the nitrogen doping could enhance the response of photocatalyst to the visible light and improve the photocatalytic activity because of the narrowing of band gap of TiO₂.     

环己硅烷类液晶化合物的量子化学研究

运用AM1和PM3两种SCF-MO方法，通过能量梯度全优化计算，给出20种环己硅烷类（苯基乙烷系）液晶化合物的稳定几何构型、电子结构和基本性质．联系有机电子结构理论进行了细致的讨论．     

Direct melting polycondensation and characterization of poly(ɛ-caprolactone-co-lactic acid)

A kind of biodegradable material, poly(ɛ-caprolactone-co-lactic acid) [P(CL-co-LA)] was synthesized via the direct melting polycondensation of lactic acid (LA) and ɛ-caprolactone (CL). The influences of the polycondensation time, and the catalyst type on the intrinsic viscosity of P(CL-co-LA) were also investigated. The results indicate that P(CL-co-dl-LA), with an intrinsic viscosity of 0.4733 dL/g, can be prepared by direct melting polycondensation with the molar ratio LA/CL = 3:7 at 180°C and 70 Pa for 12 h, using 0.5% (mass fraction) of SnCl₂ as the catalyst. Compared with lactide ring-opening polycondensation (ROP), the direct melting polycondensation of LA and CL is more practicable and simple. Translated from Journal of South China University of Technology, 2006, 34(7): 7–11 (in Chinese)     

Simultaneous EQCM and diffuse reflectance UV-visible spectroelectrochemical measurements: poly(aniline-co-o-anthranilic acid) growth and property characterization

Piezoelectric diffuse reflectance spectroelectrochemistry (PDRSEC), a new technique of diffuse reflectance spectroelectrochemistry (DRSEC) in combination with electrochemical quartz crystal microbalance (EQCM), was developed to study the electrochemical copolymerization of aniline and o-anthranilic acid in 1.0 mol l(-1) HClO4 and the properties of these copolymers. The DRSEC using an integral sphere was proven to possess a higher optical sensitivity at the unpolished piezoelectric quartz crystal electrodes used than the mirror reflectance spectroelectrochemistry mode. The copolymers grown from the copolymerization bath of different molar fractions of o-anthranilic acid (F1, relative to the total amount of the two monomers) showed intermediate properties between those of the homopolymers, which varied gradually with F1. The swelling/dissolution behavior of the copolymers vs solution pH was traced via the EQCM frequency and resistance signals, and its large dependence on F1 was found and discussed. In a HAc-NaAc buffer solution at pH 5.6, the amount of adsorbed lysozyme was found to be positively correlated with F1, via an EQCM impedance investigation, demonstrating the feasibility of using poly(aniline-co-o-anthranilic acid) as a load-adjustable immobilization matrix for cationic proteins. The novel PDRSEC method proposed is highly recommended for surface electrochemistry studies at relatively rough electrodes.     

Octasilsesquioxane Chemistry II. Hydrosilylation Reaction of Octa(hydrido)silsesquioxane with Unsaturated Substrates and Product Properties

The hydrosilylation reaction of octa(hydrido)silsesquioxane with ω‐halo‐1‐alkenes and other unsaturated substrates allows attachment of 8 long‐chain functionalized alkyls on the cubic Si₈O₁₂ skeleton. Pt/C and H₂PtCl₆ have been adopted as the catalysts, the yields being 74–98% for compounds 2–9 . For terminal alkenes, the hydrosilylation follows the anti‐Markonikov's rule. The morphological state of 2–9 ranges from viscous liquid to crystalline materials. The pyrolysis results indicate that 7 , a material of hard spherical core and soft flexible shell, may likely act as nanometer‐size ball bearings up to more than 400 °C. The X‐ray structure of 9 reveals that the molecule is required to possess a center of symmetry crystallographically. The linear arms on 9 , except for two of them, are virtually all‐trans in conformation, not counting the ω‐C‐Cl bond.     

A New Asterosaponin from the Starfish Culcita novaeguineae

A new asterosaponin named novaeguinoside A, along with a known saponin, asteronyl pentaglycoside sulfate, was isolated from the starfish Culcita novaeguineae. The new compound was identitied to be sodium 6α-O-{β-D-fucopyranosyl-(1→2)-β-D-fucopyranosyl-(1→4)-[β-D-quinovopyranosyl-(1→2)]-β-D-xylopyranosyl-(1→3)-[β-D-quinovopyranosyl}-5α-pregn-9(11)-en-20-one-3β-yl-sulfate by extensive spectral analysis and chemical evidence.     

胶束溶液中高氯酸二水(四胺)合钴(Ⅲ)配合物催化磷酸二酯水解的研究

本文合成了疏水性高氯酸二水（四胺）合钴（Ⅲ）配合物，研究了它与非离子表面活性剂Brij35形成的金属2胶束催化二（对硝基苯酚）磷酸二酯水解的动力学及其机理。结果表明此金属胶束对磷酸二酯水解的速率大约提高10^4倍，这主要是由于表面活性剂胶束的pH效应和浓聚效应所致，暗示着顺式二水类配合物形成的金属胶束是一个潜在的磷酸二酯水解剪切的催化剂。