多模调制曲面超精密加工轨迹优化技术

研究了采用单点金刚石超精密车削加工技术(SPDT)加工多模调制曲面过程中的刀具轨迹优化方法,首先,分析了SPDT方法加工多模调制曲面的基本原理;其次,理论分析了平行弦双圆弧插补算法的基本原理,推导了插补误差计算公式。在此基础上,提出采用插补步长伸缩变化方式实现了插补误差的动态控制,并获得了完整的插补计算公式;最后,采用Matlab软件对该插补算法进行了实例仿真分析,并分别与直线插补算法和固定步长双圆弧插补算法进行了对比分析,结果表明,该方法能在保证插补允差的前提下最大程度的减少插补区间数,从而有助于提高加工效率和延长刀具寿命。该方法在调制靶金属模板的制备中获得了广泛应用。     

空间层叠矩形阵列式角多路解码光路设计

根据角多路技术原理,提出了一种矩形阵列空间层叠形式的解码光路结构和先分组解码再组内解码的两步解码方式,并针对本实验室的高功率准分子激光系统给出了具体的解码光路设计实例。该方法具有解码精度高,设计误差小,与光路准直、激光参数测量系统等兼容性好,便于加工制作和安装调试等优点。     

Z箍缩驱动混合堆包层瞬态传热特性

Z箍缩驱动聚变-裂变混合能源堆（Z-FFR）以较长周期（10 s）脉冲式运行,为实现3000 MW的热功率输出,单个脉冲需要产生的能量较大,包层和第一壁在强热冲击下的瞬态传热和温度特性是决定Z-FFR技术可行性的关键问题之一。通过理论计算,分析了在连续脉冲作用下包层和第一壁温度随时间的变化规律。同时以输出恒定的电功率为目标,提出了展平系统输出功率的简便方法,并分析了出口冷却剂温度的波动特性。结果表明材料最高温度均在安全限值内,第一壁表面瞬时高温层厚度约为0.5 mm,系统输出功率波动幅度在-2.84%~+2.05%范围内。     

高功率光隔离器永磁系统的理论研究与优化

基于阵列永磁体的特点以及光隔离器对磁场的需求设计了两种适用于高功率隔离器的永磁系统,分析了其磁场分布、磁场非均匀性对隔离度的影响,研究了磁体装配误差对磁场的影响。研究结果表明：通过引入斜向磁化永磁体,选择合适的磁化角度和磁体长度,可以提高永磁体的磁场强度,大幅度减小旋转器所需磁光晶体长度;受磁场非均匀性影响的隔离度与磁光晶体的孔径、长度以及入射激光的光斑半径有关,当晶体长度一定时,减小晶体半径和入射光的半径可以显著提高隔离度。在入射光半径为1.5 mm、磁光晶体半径5 mm时,对应的隔离度分别为105.8 dB和45.4 dB。     

增殖剂球床载气体流动特性

增殖剂球床是聚变堆或混合堆产氚包层可选结构之一,准确把握增殖剂球床中载带气体的流动特性有助于提高对球床载氚过程的认识并优化包层设计。采用离散元程序PFC3D模拟增殖剂小球的填充行为,在球床内不同位置随机截取不同尺寸的控制体,利用布尔运算中的差集得到孔隙范围,建立孔隙分布的三维几何模型,进一步划分网格并用计算流体力学（CFD）方法求解,得出控制体上单位长度的压降以及单元体内的速度分布特征,计算结果发现载带气体速度分布与分布很类似,且只要选取恰当的控制体,通过计算流体力学方法可以较好地分析整个球床孔隙内流体的流动,有利于进一步研究载氚及相关过程。     

铜活化法诊断神光Ⅲ主机装置氘氚中子产额

介绍了铜活化诊断氘氚中子产额的测量原理,分析了62Cu和64Cu两种活化核素在符合测量中的贡献。针对不同范围内的中子产额测量,提出了系统灵敏度相对标定法和64Cu活化核标定法。通过添加中子屏蔽锥测量了标定场所散射中子影响。计算评估了63Cu(n,)64Cu反应过程对活化测量的影响。在神光Ⅲ主机装置上,利用该系统测量了直接驱动氘氚中子产额。实验结果表明：氘氚中子产额在109~1013范围采用相对标定方法较为合适,64Cu活化核的标定方法适用于1012~1016范围内产额测量。标定场所散射中子对灵敏度标定因子影响约0.4%。63Cu俘获辐射反应在64Cu活化核标定中贡献小于1%。目前神光Ⅲ主机装置直接驱动氘氚中子产额约81012。     

受激布里渊散射并行数值模拟研究

为了更深入地研究激光与等离子体相互作用中受激Brillouin散射不稳定性的物理机制,建立了受激Brillouin散射三波耦合数学模型,根据方程组的形式以及数学特征, 采用算子分裂方法,坐标平移,高效的并行傅里叶变换和归约密度等算法,编制模拟受激Brillouin散射不稳定性的并行程序,并用数值算例证明其有效性,最后采用近3亿固定网格规模,扩展到4096个核上测试并行性能,并行效率达到81.6%。     

Protective Effects of Ferulic Acid on Metabolic Syndrome: A Comprehensive Review

Metabolic syndrome (MetS) is a complex disease in which protein, fat, carbohydrates and other substances are metabolized in a disorderly way. Ferulic acid (FA) is a phenolic acid found in many vegetables, fruits, cereals and Chinese herbs that has a strong effect on ameliorating MetS. However, no review has summarized the mechanisms of FA in treating MetS. This review collected articles related to the effects of FA on ameliorating the common symptoms of MetS, such as diabetes, hyperlipidemia, hypertension and obesity, from different sources involving Web of Science, PubMed and Google Scholar, etc. This review summarizes the potential mechanisms of FA in improving various metabolic disorders according to the collected articles. FA ameliorates diabetes via the inhibition of the expressions of PEPCK, G6Pase and GP, the upregulation of the expressions of GK and GS, and the activation of the PI3K/Akt/GLUT4 signaling pathway. The decrease of blood pressure is related to the endothelial function of the aortas and RAAS. The improvement of the lipid spectrum is mediated via the suppression of the HMG-Co A reductase, by promoting the ACSL1 expression and by the regulation of the factors associated with lipid metabolism. Furthermore, FA inhibits obesity by upregulating the MEK/ERK pathway, the MAPK pathway and the AMPK signaling pathway and by inhibiting SREBP-1 expression. This review can be helpful for the development of FA as an appreciable agent for MetS treatment.     

Simultaneous Determination of Six Immunosuppressants in Human Whole Blood by HPLC-MS/MS Using a Modified QuEChERS Method

A high-performance liquid chromatography-tandem mass spectrometry method was established for the simultaneous determination of mycophenolic acid, mycophenolate mofetil, tacrolimus, rapamycin, everolimus and pimecrolimus in human whole blood by optimizing the QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) preparation method. Whole blood was extracted into ethyl acetate, salted out with anhydrous magnesium sulfate, and purified with ethylenediamine-N-propyl silane adsorbent. The supernatant was evaporated under nitrogen until dry and finally reconstituted in methanol. Chromatographic separation was performed on an Agilent Poroshell 120 EC-C18 column in methanol (mobile phase A)-water (optimized for 0.1% acetic acid and 10 mM ammonium acetate, mobile phase B) at a 0.3 mL·min⁻¹ flow rate. Electrospray ionization and positive ion multiple reaction monitoring were used for detection. The time for of analysis was 13 min. The calibration curves range of tacrolimus, rapamycin, everolimus and pimecrolimus were in the range of 1–100 ng·mL⁻¹, mycophenolate mofetil in the range of 0.1–10 ng·mL⁻¹ and mycophenolic acid at 10–1000 ng·mL⁻¹. All correlation coefficients were >0.993. The coefficients of variation (CV, %) for inter-day and intra-day precision were less than 10%, while the spiked recoveries were in the range of 92.1% to 116%. Our method was rapid, sensitive, specific, and reproducible for the simultaneous determination of six immunosuppressants in human whole blood. Importantly, our approach can be used to monitor drug concentrations in the blood to facilitate disease treatment.