全文获取类型
收费全文 | 15289篇 |
免费 | 2638篇 |
国内免费 | 2559篇 |
专业分类
化学 | 12055篇 |
晶体学 | 200篇 |
力学 | 695篇 |
综合类 | 256篇 |
数学 | 1603篇 |
物理学 | 5677篇 |
出版年
2024年 | 45篇 |
2023年 | 279篇 |
2022年 | 489篇 |
2021年 | 506篇 |
2020年 | 621篇 |
2019年 | 642篇 |
2018年 | 540篇 |
2017年 | 509篇 |
2016年 | 807篇 |
2015年 | 848篇 |
2014年 | 912篇 |
2013年 | 1200篇 |
2012年 | 1341篇 |
2011年 | 1430篇 |
2010年 | 1007篇 |
2009年 | 1025篇 |
2008年 | 1099篇 |
2007年 | 962篇 |
2006年 | 948篇 |
2005年 | 859篇 |
2004年 | 676篇 |
2003年 | 592篇 |
2002年 | 636篇 |
2001年 | 468篇 |
2000年 | 415篇 |
1999年 | 316篇 |
1998年 | 205篇 |
1997年 | 182篇 |
1996年 | 175篇 |
1995年 | 137篇 |
1994年 | 118篇 |
1993年 | 98篇 |
1992年 | 71篇 |
1991年 | 52篇 |
1990年 | 46篇 |
1989年 | 43篇 |
1988年 | 31篇 |
1987年 | 33篇 |
1986年 | 29篇 |
1985年 | 23篇 |
1984年 | 9篇 |
1983年 | 11篇 |
1982年 | 7篇 |
1981年 | 7篇 |
1980年 | 4篇 |
1979年 | 4篇 |
1977年 | 5篇 |
1975年 | 4篇 |
1973年 | 4篇 |
1957年 | 5篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
82.
Yi Gao Xuesong Yao Qinggeng Jiang Jianhe Liao Yongping Chen Rentong Yu 《Molecules (Basel, Switzerland)》2022,27(10)
Microgels have unique and versatile properties allowing their use in forward osmosis areas as a draw agent. In this contribution, poly(4-vinylpyridine) (P4VP) was synthesized via RAFT polymerization and then grafted to a poly(N-Isopropylacrylamide) (PNIPAAm) crosslinking network by reverse suspension polymerization. P4VP was successfully obtained by the quasiliving polymerization with the result of nuclear magnetic resonance and gel permeation chromatography characterization. The particle size and particle size distribution of the PNIPAAm-g-P4VP microgels containing 0, 5, 10, 15 and 20 wt% P4VP were measured by means of a laser particle size analyzer. It was found that all the microgels were of micrometer scale and the particle size was increased with the P4VP load. Inter/intra-molecular-specific interactions, i.e., hydrogen bond interactions were then investigated by Fourier infrared spectroscopy. In addition, the water flux measurements showed that all the PNIPAAm-g-P4VP microgels can draw water more effectively than a blank PNIPAAm microgel. For the copolymer microgel incorporating 20 wt% P4VP, the water flux was measured to be 7.48 L∙m−2∙h−1. 相似文献
83.
84.
Ben Li Yumeng Ji Chenlong Yi Xufeng Wang Chaoyang Liu Chufan Wang Xiaohu Lu Xiaohan Xu Xiaowei Wang 《Molecules (Basel, Switzerland)》2022,27(13)
Atherosclerosis (AS) is one of the leading causes of death among the elderly, and is primarily caused by foam cell generation and macrophage inflammation. Rutin is an anti-inflammatory, anti-oxidant, anti-allergic, and antiviral flavonoid molecule, known to have anti-atherosclerotic and autophagy-inducing properties, but its biological mechanism remains poorly understood. In this study, we uncovered that rutin could suppress the generation of inflammatory factors and reactive oxygen species (ROS) in ox-LDL-induced M2 macrophages and enhance their polarization. Moreover, rutin could decrease foam cell production, as shown by oil red O staining. In addition, rutin could increase the number of autophagosomes and the LC3II/I ratio, while lowering p62 expression. Furthermore, rutin could significantly inhibit the PI3K/ATK signaling pathway. In summary, rutin inhibits ox-LDL-mediated macrophage inflammation and foam cell formation by inducing autophagy and modulating PI3K/ATK signaling, showing potential in treating atherosclerosis. 相似文献
85.
本文阐述了Flash cs3 AcdonScript课件的优势及如何利用Flashcs3中具有的强大编程功能的AetionScript脚本语言制作大学物理CAI课件。 相似文献
86.
87.
Chiral chromanone lactones are a class of natural products with important biological activity. We report a direct diastereo- and enantioselective vinylogous conjugate addition of butenolide to 2-ester substituted chromones. The transformation proceeded well in the presence of as low as 1 mol% of a chiral N,N′-dioxide/ScIII complex, 3 Å MS and a catalytic amount of hexafluoroisopropanol (HFIP). The scope of Michael acceptors includes a variety of substituted chromones at different positions, and the desired chromanone lactones upon reduction are afforded in good yield and diastereoselectivity, and excellent enantioselectivity (up to 99% ee). The strategy could be used in the concise synthesis of blennolide C and gonytolide A, C and G.We report a direct, diastero- and enantioselective vinylogous 1,4-addition of butanolide to 2-ester chromones. A chiral ScIII complex enabled the reaction to proceed smoothly to give a variety of chraomanone lactones. 相似文献
88.
The symmetries and non-Noether conservation laws of
Birkhoffian system with unilateral constraints are studied. The
differential equations of motion of the system are established,
and the criterions of Noether symmetry, Lie symmetry and Mei
symmetry of the system are given. Two types of new conservation
laws, called the Hojman conservation law and the Mei conservation
law respectively, are obtained, and the intrinsic relations among
the symmetries and the new conservation laws are researched.
At the end of the paper, an example is given to illustrate the
application of the results. 相似文献
89.
Bin-Long Sun Ying-Ying Wang Sen Yang Min-Ting Tu Ying-Ying Shao Yi Hua Yi Zhou Cheng-Xia Tan 《Molecules (Basel, Switzerland)》2022,27(12)
To develop new compounds with high activity, broad spectrum and low-toxicity, 17 benzamides substituted with quinoline-linked 1,2,4-oxadiazole were designed using the splicing principle of active substructures and were synthesized. The biological activities were evaluated against 10 fungi, indicating that some of the synthetic compounds showed excellent fungicidal activities. For example, at 50 mg/L, the inhibitory activity of 13p (3-Cl-4-Cl substituted, 86.1%) against Sclerotinia sclerotiorum was superior to that of quinoxyfen (77.8%), and the inhibitory activity of 13f (3-CF3 substituted, 77.8%) was comparable to that of quinoxyfen. The fungicidal activities of 13f and 13p to Sclerotinia sclerotiorum were better than that of quinoxyfen (14.19 mg/L), with EC50 of 6.67 mg/L and 5.17 mg/L, respectively. Furthermore, the acute toxicity of 13p was 19.42 mg/L, classifying it as a low-toxic compound. 相似文献
90.
Yi Wang Xiangli Zhang Wenya Zhuang Yanlei Yu Xuanrong Sun Hong Wang Fengzhi Li Qingyong Li 《Molecules (Basel, Switzerland)》2022,27(12)
Irinotecan and Topotecan are two Camptothecin derivatives (CPTs) whose resistance is associated with the high expression of breast cancer resistance protein (BCRP) and P-glycoprotein (P-gp). To reverse this resistance, two novel CPTs, FL77-28 (7-(3-Fluoro-4-methylphenyl)-10,11-methylenedioxy-20(S)-CPT) and FL77-29 (7-(4-Fluoro-3-methylphenyl)-10,11-methylenedioxy-20(S)-CPT), were synthesized by our group. In this study, the anti-tumor activities of FL77-28, FL77-29, and their parent, FL118 (10,11-methylenedioxy-20(S)-CPT), were evaluated and the results showed that FL77-28 and FL77-29 had stronger anti-tumor activities than FL118. The transport and uptake of FL118, FL77-28, and FL77-29 were investigated in Caco-2 cells for the preliminary prediction of intestinal absorption. The apparent permeability coefficient from apical to basolateral (Papp AP-BL) values of FL77-28 and FL77-29 were (2.32 ± 0.04) × 10−6 cm/s and (2.48 ± 0.18) × 10−6 cm/s, respectively, suggesting that the compounds had moderate absorption. Since the transport property of FL77-28 was passive diffusion and the efflux ratio (ER) was less than 2, two chemical inhibitors were added to further confirm the involvement of efflux proteins. The results showed that FL77-28 was not a substrate of P-gp or BCRP, but FL77-29 was mediated by P-gp. In conclusion, FL77-28 might be a promising candidate to overcome drug resistance induced by multiple efflux proteins. 相似文献