Co-delivery of doxorubicin and AS1411 aptamer by poly(ethylene glycol)-poly(<Emphasis Type="Italic">β</Emphasis>-amino esters) polymeric micelles for targeted cancer therapy

Recently, targeted drug delivery systems (TDDS) have offered a great potential and benefits towards the anti-tumor drug delivery. In this work, we designed the TDDS using a biocompatible poly(ethylene glycol)-poly(β-amino esters) amphiphilic block copolymer (PEG-PAEs) synthesized by Michael addition polymerization for combinatorial therapy. Further, the chemotherapeutic agents’ doxorubicin (DOX) and AS1411 DNA aptamer (Apt) are encapsulated in the PEG-PAEs NPs (PDANs) for co-delivery therapeutics. PDANs have shown the monodisperse spherical shape, smooth surface with a net positive charge (average diameter—183.1 ± 27.2 nm, zeta potential—31.2 ± 6.3 mV), and good colloidal stability (critical micelle concentration of PEG-PAEs is about 6.3 μg/mL). The pH-sensitive PAEs endowed PDANs both pH-triggered drug release characteristics and enhanced endo/lysosomal escape ability, thus improving the localization and cytotoxicity of DOX. AS1411 Apt conjugated PDANs precisely targeted nucleolin and their uptake correlates to a significant activity enhancement only in tumor cells (MCF-7) but not in normal cells (MCF-10A). Thus, PDANs can be a very promising targeted drug delivery platform for effective breast cancer therapy.

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Graphical abstract Scheme 1 Schematic illustration of the preparation and cellular uptake of targeted co-delivery system

     

双路输出超宽谱高功率微波驱动源Tesla变压器

为实现25 GW级双路输出超宽谱高功率微波驱动源的小型化,选择研制了一种与双筒脉冲形成线(Blumlein线)相配一体化的带有开路磁芯的Tesla变压器,作为初级脉冲功率源。进行了Tesla变压器的理论分析,利用简化的磁路模型研究了Tesla变压器初次级线圈电感等电参数的估算方法,给出了Tesla变压器磁芯截面的估算和磁芯制作方法。该Tesla变压器最大输出电压880 kV,充电时间约20 s,耦合系数约0.95,实验结果与理论设计相符。     

4H-SiC肖特基二极管的电荷收集特性

针对极端环境下耐辐照半导体核探测器的研制需求,采用耐高温、耐辐照的4H碳化硅(4H-SiC)宽禁带材料制成肖特基二极管,研究了该探测器对241Am源粒子的电荷收集效率。从电容-电压曲线得出该二极管外延层净掺杂数密度为1.991015/cm3。从正向电流-电压曲线获得该二极管肖特基势垒高度为1.66 eV,理想因子为1.07,表明该探测器具备良好的热电子发射特性。在反向偏压高达700 V时,该二极管未击穿,其漏电流仅为21 nA,具有较高的击穿电压。在反向偏压为0~350 V范围内研究了该探测器对3.5 MeV 粒子电荷收集效率,在0 V时为48.7%,在150 V时为99.4%,表明该探测器具有良好的电荷收集特性。     

宽波段连续调谐全固态CW PPMgLN光学参量振荡器

利用半导体激光泵浦输出1064 nm波长的全固态连续Nd:YVO4激光器作为泵浦源,采用周期调谐和温度调谐组合调谐技术,对基于掺氧化镁周期性极化铌酸锂晶体（MgO:LiNbO3, PPMgLN）准相位匹配（QPM）的全固态连续波（CW）光学参量振荡器（OPO）宽波段无分立连续调谐输出特性进行研究。实验采用连续工作模式和外腔结构,基于多周期PPMgLN晶体的30.2,30.4和30.6 m周期,在改变晶体的极化周期的基础上,同时在30～100 ℃范围内调节晶体工作温度。实验结果表明:CW PPMgLN OPO的泵浦阈值仅为0.22 W;不同极化周期需要的温度调谐范围不同;信号光在1 559.8～1 597.2 nm近红外波段和闲频光在3 187.3~3 347.3 nm中红外波段连续调谐输出。实现了外腔式全固态CW OPO在信号光和闲频光波段的无分立连续调谐输出。     

A low specific on-resistance SOI MOSFET with dual gates and a recessed drain

A low specific on-resistance(Ron,sp) integrable silicon-on-insulator(SOI) metal-oxide semiconductor field-effect transistor(MOSFET) is proposed and investigated by simulation.The MOSFET features a recessed drain as well as dual gates,which consist of a planar gate and a trench gate extended to the buried oxide layer(BOX)(DGRD MOSFET).First,the dual gates form dual conduction channels,and the extended trench gate also acts as a field plate to improve the electric field distribution.Second,the combination of the trench gate and the recessed drain widens the vertical conduction area and shortens the current path.Third,the P-type top layer not only enhances the drift doping concentration but also modulates the surface electric field distributions.All of these sharply reduce Ron,sp and maintain a high breakdown voltage(BV).The BV of 233 V and Ron,sp of 4.151 mΩ·cm2(VGS = 15 V) are obtained for the DGRD MOSFET with 15-μm half-cell pitch.Compared with the trench gate SOI MOSFET and the conventional MOSFET,Ron,sp of the DGRD MOSFET decreases by 36% and 33% with the same BV,respectively.The trench gate extended to the BOX synchronously acts as a dielectric isolation trench,simplifying the fabrication processes.     

中学生物理学习态度的调查与比较——不同物理成绩的农村初三学生的研究

对昆明市西山区某农村中学初三年级的学生作问卷调查,按照物理成绩将学生分为80～100分、60～80分、60分以下三个组,对比分析各组学生物理学习态度差异.研究表明,三个组的学生在物理学习态度8个具体指标上均存在差异,根据不同组别在物理学习态度上的特点,提出了教学建议.     

变工况下旋转机械故障跟踪的相空间曲变方法

为实现在工况变化条件下对旋转机械的故障预测, 提出使用相空间曲变和平滑正交分解理论在变工况条件下跟踪旋转机械的故障演化过程. 首先在对目标系统的观测时间序列相空间重构的基础上, 通过量化相空间曲变构建信号损伤演化的跟踪函数, 为弥补累积模型误差和相空间点局部分布概率差异造成的误差, 将时间序列和相空间进行分割, 并以此构建跟踪矩阵; 再利用平滑正交分解方法将跟踪矩阵中分别由实际损伤劣化和工况变化造成的演化趋势进行分离, 根据平滑正交特征值提取出其中能够反映实际故障演化趋势的平滑正交分量; 最后以变转速情况下轴承外环故障退化的仿真信号为例验证算法的有效性. 计算结果表明: 本文提出的算法能够对旋转机械故障的演化趋势实现有效跟踪, 基本排除转速波动造成的工况变化影响. 关键词： 相空间曲变 平滑正交分解 变工况 故障跟踪     

实际气体R134a在离心叶轮内部流动的数值研究

使用实际气体模型对R134a在半开式离心压缩机叶轮内部三维湍流进行了数值计算,比较了比容比相等情况下实际及理想气体模型对压缩过程的差异.研究表明二者设计流量系数基本相等,但实际气体的多变效率低于相应的理想气体计算值;数值计算能够较好地预测实际气体的流动结构和性能参数的变化规律,对实际气体制冷压缩机气动热力设计具有理论及工程意义.     

非均匀性对单层膜光学特性的影响

探讨了不同规律的非均匀性对单层膜的光谱特性的影响,与均匀单层膜对比发现：折射率正变引起透射率的极大值减小,折射率负变引起透射率的极大值变大,当非均匀性很小时,透射率的极小值基本不变.对实验制备的单层膜从实验和理论上进行了对比并给出了较好的拟合,发现在薄膜和基底的界面处存在一过渡层,过渡层可近似为线性,并从理论上给予了分析解释.     

Field expulsion and reconfiguration in polaritonic photonic crystals

We uncover a rich set of optical phenomena stemming from the incorporation of polar materials exhibiting transverse phonon polariton excitations into a photonic crystal structure. We identify in the frequency spectrum two regimes in which the dielectric response of the polaritonic medium can induce extreme localization of the electromagnetic energy. Our analysis of the effect of polarization and the interaction between the polariton and photonic band gaps on the Bloch states leads to a pair of mechanisms for sensitive frequency-controlled relocation and/or reconfiguration of the fields.