Selective synthesis of N-substituted pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives via alkyne cyclization

A novel and efficient synthesis of N-substituted pyrrolo-pyrazinone derivatives has been developed. A trichloroacetyl group connected to the pyrrole ring was converted into the desired carboxamide derivatives. Promoted by NaH, the pyrrole carboxamide derivatives underwent a tandem reaction with propargyl bromide to afford pyrrolo-pyrazinones with high efficiency under very mild conditions. The mechanism for the formation of the products is discussed and supported by DFT calculations.     

Transport studies at the Mott transition of the two-dimensional organic metal κ-(BEDT-TTF)2Cu[N(CN)2]BrxCl1-x

The two-dimensional organic conductor κ-(BEDT-TTF)₂Cu[N(CN)₂]Br _x Cl_{1- x} undergoes a transition from an insulator to a superconductor upon substituting Cl by Br. We have performed in- and out-of-plane electric-transport measurements on the alloyed series with x = 20%, 40%, 70%, 80%, 85%, and 90% as a function of temperature in order to explore the bandwidth-controlled phase transition between the Mott insulator and the Fermi-liquid. All crystals exhibit a similar semiconducting behavior of ρ(T) from room temperature down to 100 K. Below approximately 50 K, a metal-to-insulator transition is found for compounds with x < 70%. Out of this Mott insulating state, magnetic order develops below T _N ≈ 25 K. The Br-rich samples cross a bad-metal regime before they become coherent metals and eventually superconducting at T _c ≈ 12 K. For these systems the resistivity at T _c ≤ T ≤ T ₀ reveals a ρ(T) ∝ T ² dependence associated with a strongly correlated Fermi-liquid, limited by some characteristic temperature T ₀. The conclusions are corroborated by data from microwave, magnetic and optical experiments.     

A greedy algorithm for partition of unity collocation method in pricing American options

A greedy algorithm in combination with radial basis functions partition of unity collocation (GRBF‐PUC) scheme is used as a locally meshless method for American option pricing. The radial basis function partition of unity method (RBF‐PUM) is a localization technique. Because of having interpolation matrices with large condition numbers, global approximants and some local ones suffer from instability. To overcome this, a greedy algorithm is added to RBF‐PUM. The greedy algorithm furnishes a subset of best nodes among the points X. Such nodes are then used as points of trial in a locally supported RBF approximant for each partition. Using of greedy selected points leads to decreasing the condition number of interpolation matrices and reducing the burdensome in pricing American options.     

Preparation, structural analysis and dielectric properties of Bi x La1−x FeO3 perovskite

Rare earth element substituted bismuth ferrites (BiFeO₃) are of enormous importance as magnetoelectric materials. The polycrystalline samples of Bi _x La_1−x FeO₃ (x=0, 0.2, 0.4, 0.6, 0.8) were prepared by solid-state reaction using standard ceramic method. The single-phase formation of these compounds was confirmed by X-ray diffraction (XRD) studies. The samples with x=0, 0.2, 0.4, 0.6 are found to be orthorhombic while the sample with x=0.8 is triclinic. The dielectric constant (ε′) and dissipation factor (tan δ) were measured in the frequency range 100 Hz to 1 MHz at room temperature and as a function of temperature at certain fixed frequencies (1 kHz, 10 kHz, 100 kHz, 1 MHz). All the samples showed dielectric dispersion. The dielectric constant with temperature shows a broad peak; the peak temperature shifts with frequency which reflects the relaxor-type behavior. The peak above 600 K in the measured temperature range corresponds to antiferromagnetic ordering temperature (Néel temperature). The broadness of the peak changes with composition. The ac conductivity as well as ε′ are found to be maximum for the sample x=0.2 at room temperature.     

Magnetoelectric effect in cobalt ferrite-barium titanate composites and their electrical properties

CoFe₂O₄-BaTiO₃ composites were prepared using conventional ceramic double sintering process with various compositions. Presence of two phases in the composites was confirmed using X-ray diffraction. The dc resistivity and thermoemf as a function of temperature in the temperature range 300 K to 600 K were measured. Variation of dielectric constant (ɛ′) with frequency in the range 100 Hz to 1 MHz and also with temperature at a fixed frequency of 1 kHz was studied. The ac conductivity was derived from dielectric constant (ɛ′) and loss tangent (tan δ). The nature of conduction is discussed on the basis of small polaron hopping model. The static value of magnetoelectric conversion factor has been studied as a function of magnetic field.     

The characteristics of proton and induced neutron-emulsion high energy interactions

We used the technique of the separation of Coulomb and diffraction dissociation of incident heavy ion to select the events due to induced neutron from ¹⁶O leaving sub-oxygen nucleus to break-up. The characteristics of these events of neutron emulsion collisions are displayed and compared with that obtained from incident proton at the same energy.

The studied interactions are classified according to the type of target nucleus (H, CNO and AgBr) by using the method of separation. Cascade-evaporation model (CEM) calculations are taken into account and compared with that obtained from the interactions of induced neutron from ¹⁶O (4.5 A GeV/c) with emulsion nuclei and with the results of incident proton at the same target and energy. CEM can describe the distributions of proton and neutron interactions. It is conjuctured that it may be possible to develop a similar theoretical model based on the modern methods of nonlinear dynamics, neural network and complexity [Randomness and Undecidability in Physics, World Scientific, Singapore, 1993].     

Multifunctional Magnetic Nanomedicine Drug Delivery and Imaging-Based Diagnostic Systems

Magnetically guided drug transportation is a technique in which magnetic pharmaceutical transporters in organisms are controlled by applied magnetic forces to deliver drugs to the desired location. Different magnetic drug delivery systems (MDDSs) are developed to treat a variety of illnesses, particularly cancer and neurological disorders. However, a unique magnetic setup is required in each application for an effective magnetically guided drug aiming to direct the drug-carrying nanocarriers to the intended area. The current and future perspectives of MDDS are investigated in this study by considering their biological functions, deliverable efficiency, complexity, and the nature of the externally applied magnetic field. Despite the fact that MDDSs have low cytotoxicity, regulated magneto reactivity, extended circulation lifespan, and high surface stability, very few clinical studies have been conducted to date in order to achieve optimized therapeutic efficacy before entering the market. In recent studies, the development of novel magnetic medication transporting carriers is preferred over direct magnetic medication administration. Better functional magnetic targeting technologies are required for such breakthroughs to enter clinical trials. Because MDDSs are unlikely to work in all clinical situations, more focused research is needed to replace or improve the strategy for treating multiple illnesses.     

Computational analysis of non-isothermal temperature distribution on natural convection in nanofluid filled enclosures

In this study, the problem of steady state natural convection in an enclosure filled with a nanofluid has been analyzed numerically by using heating and cooling by sinusoidal temperature profiles on one side. The governing partial differential equations, in terms of the dimensionless stream function–vorticity and temperature, are solved numerically using the finite volume method for various inclination angles 0^°≤?≤90^°$0^{°}\le ?\le 90^{°}$, different types of nanoparticles (TiO₂ and Al₂O₃) and fractions of nanoparticles 0≤φ≤0.1$0\le \phi \le 0.1$, whereas the range of the Rayleigh number Ra is 10³–10⁵. It is found that the addition of nanoparticles into water affects the fluid flow and temperature distribution especially for higher Rayleigh numbers. An enhancement in heat transfer rate was registered for the whole range of Rayleigh numbers. However, low Rayleigh numbers show more enhancement compared to high Rayleigh numbers.     

多光子过程中相位退相干时两原子布局数反转

利用全量子理论的方法,研究了存在相位退相干时多光子T-C模型中两个二能级原子与二项式光场相互作用系统中两原子的布居数反转。讨论了相位退相干系数、二项式光场系数、最大光子数、跃迁光子数对原子布居数反转的影响。结果表明：相位退相干减少了原子布居数反转的振幅、破坏了原子的量子特性。改变跃迁光子数,可以改变原子间布居数反转演化周期及演化强度。当二项式光场的最大光子数增大时,原子布居差的崩塌-回复现象就会逐渐消失。相位退相干因子不变时, 二项式光场从相干态过渡到数态过程中,原子布居的振荡频率由大变小,周期性的崩塌与回复现象逐渐消失。     

Lower limits of detection in speciation analysis by coupling high-performance liquid chromatography and chemical-vapor generation

Speciation studies are much more important than total element determination because toxicity of many elements depends on their chemical forms. Nobody can claim that a foodstuff is very dangerous to eat by determining total arsenic due to the possibility that the arsenic could be present in non-toxic forms. Hence, speciation studies are crucial in any matrix relevant to human beings.Trace-element speciation requires sufficiently sensitive procedures to monitor each species at trace levels. One way to increase the sensitivity for elements forming volatile species is coupling high-performance liquid chromatography (HPLC) with chemical-vapor generation (CVG). This review aims to highlight not only development of HPLC-CVG techniques for ultratrace-elemental speciation in a variety of matrices but also their application. In addition, we discuss the advantages and the disadvantages of these techniques.