Targeted Delivery of Anticancer Drug Loaded Charged PLGA Polymeric Nanoparticles Using Electrostatic Field

Pure positive electrostatic charges (PPECs) show suppressive effect on the proliferation and metabolism of invasive cancer cells without affecting normal tissues. PPECs are used for the delivery of drug-loaded polymeric nanoparticles (DLNs) capped with negatively charged poly(lactide-co-glycolide) (PLGA) and Poly(vinyl-alcohol) PVA into the tumor site of mouse models. The charged patch is installed on top of the skin in the mouse models' tumor region, and the controlled selective release of the drug is assayed by biochemical, radiological, and histological experiments on both tumorized models and normal rats' livers. It is found that DLNs synthesized by PLGA show great attraction to PPECs due to their stable negative charges, which would not degrade immediately in blood. The burst and drug release after less than 48h of this synthesized DLNs are 10% and 50%, respectively. These compounds can deliver the loaded-drug into the tumor site with the assistance of PPECs, and the targeted-retarded release will take place. Hence, local therapy can be achieved with much lower drug concentration (conventional chemotherapy [2 mg kg⁻¹] versus DLNs-based chemotherapy [0.75 mg kg⁻¹]) with negligible side effects in non-targeted organs. PPECs have many potential clinical applications for advanced-targeted chemotherapy with the lowest discernible side effects.     

Correlation of Moments and Critical Phenomenon in Disassembly of Hot Nuclei

We used Monte Carlo method to generate the configurations of disassembly of hot nucleus Au* based on the Atomic Mass Table and the conservation of mass and charge number.The resulted charge distribution of fragments was then used to calculate the conditional moments.The logarithm correlation between second and third moments of experimental charge distribution is very well reproduced by theory.It seems that no connection to the critical phenomenon of concerned system exists.     

THE EFFECT OF THE FREEZE-OUT VOLUME IN THE MULTIFRAGMENTATION OF VERY HOT NUCLEAR REMNANT

In this paper a simplified method for the calculation of average Coulomb energy in statistical model of the disassembly processes of hot nuclei is proposed.The effect of freeze-out volume is studied based on the assumption of Gaussion-like distribution.It is indecated that the centre and dispersion of Gaussion-like distribution somewhat reflect the location and the renge of liquid-gas coexistence phase.     

THE EVIDENCE OF DECONFINEMENT PHASE TRANSITION OF SU(2) LATTICE GAUGE MODEL BY MONTE CARLO METHOD

In this paper,we have calculated the SU(2) lattice gauge by the Monte Carlo method.For the finite temperature problem 8³×4 lattice is used and for the zero temperature problem 8⁴ lattice.From the calculations of the energy density,heat capacity and entropy density,the results indicate that there is a deconfinement phase transition when T/Λ_L=40—50.     

THE INFLUENCE OF SUBSTITUENTS IN METALLOCENE ON PROPYLENE POLYMERIZATION*

Two new unbridged zirconocenes, bis(2,4,7-trimethyl indenyl)zirconium dichloride (Met-Ⅰ) andbis(2-methyl-4,7-diethyl indenyl)zirconium dichloride (Met-Ⅱ) were prepared in order to investigate thesteric effects of substituents on the nature of the catalysts for the polymerization of propylene. A mixture ofmethyl aluminoxane (MAO) and triisobutylaluminum [Al(iBu)_3] was used as cocatalyst to activate thesecatalysts. The decrease in steric bulkiness of substituents at 4 and 7 positions of the indenyl ring resulted inan increase of both activity and molecular weight as well as the isotacticity.     

DIRECT SIMULATION OF DEEP INELASTIC SCATTERING OF HEAVY-IONS (I) ONE PARAMETER DISTRIBUTION

The distributions of dynamic variables in the deep inelastic scattering (DIS) of heavy-ions are studied by a direct simulation technique based on the single-nucleon-transfer-mechanism. The relative motion of the two collision partners is described by a Lagrange equation, and the transition probability of a single nucleon during the interaction time is calculated by the statisti-cal spectroscopy method.The occurrence of the transition event and the corresponding change of the dynamic variables are both treated randomly according to the transition probability. The calculated results for the reaction of ⁴⁰Ar+⁵⁸Ni(E_L=280MeV) are compared with experimental data.     

Exploration for Degradation of Λ Polarization Produced in Relativistic Nucleus Nucleus Collisions

The degradation of Λ transverse polarization produced in S+Pb central collisions at energy 200 GeV per nucleon has been studied in detail. The S+Pb central collision events have been generated using Monte-Carlo generator——LUCIAE at 200 GeV per nucleon. The various factors degrading Λ transverse polarization have been analysed quantitatively. The ratios of Λ′s produced from rescattering, secondary production and decays of Σ, Ξ hyperons to the total measurable Λ′s in experiment have been investigeted and the degradation effect of these Λ on the total polarization has been determined. The simulation and calculation show that above three factors decrease the Λ transverse polarization strongly, however, can not eliminate the polarization completely when the Λ′s are assumed to be produced from hadronic gas in the final state. To explan the experimental data of vanished Λ polarization, it probably needs to consider new mechanisms of Λ production, including a weak effect of QGP formation.     

200A GeV S+Au反应中光子产生的低横动量增强

用建立在LUND弦模型特别是PYTHIA事件产生器基础上的描写极端相对论性核-核碰撞的强子和弦级联模型--JPCIAE研究了入射能量为200A GeV的S+Au中心碰撞中光子产生.模型同时考虑了部分子QCD散射过程、强子末态相互作用以及强子衰变等光子产生反应道并作了协调处理.JPCIAE模型计算结果很好再现了WA93实验数据所呈现的低横动量增强效应.     

An approach for analysing transportation costs and a case study

One of the important parameters in the determination of optimal transportation system is economy. Therefore, a realistic method based on the technical, economical and operational parameters of various transportation modes, namely, road, railway, and sea routes is required in the analysis of costs. This method will take into consideration the probable price escalations during the lifetime of a certain transportation system. The cost of a unit of cargo or passenger per route length should be considered since it is an indicator of economics. In this paper, an approach for transportation cost analysis based on the economic analysis of the alternative modes of cargo or passenger transportation, is presented.