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Xin Zheng Chen Chen Huitao Gao Xuefeng Sun Yanbao Zhang Juhong Shi Xiaohong Han 《Biomedical chromatography : BMC》2022,36(5):e5306
Rivaroxaban is an oral anticoagulant directly inhibiting the activity of Factor Xa, which is widely used for the prophylaxis of thromboembolic disorders. Therapeutic drug monitoring (TDM) is required during therapy for individual dosage adjustment. This study aimed at developing a liquid chromatography/tandem mass spectrometry method that was suitable for rivaroxaban TDM in human plasma and urine and exploring the feasibility of urine drug monitoring in medical care. A 3 min run time of the LC–MS/MS methods was established by employing an Acquity UPLC BEH C18 (2.1 × 50 mm, 1.7 μm) column using gradient elution of 10 mmol/L ammonium acetate containing 0.1% formic acid–0.1% formic acid acetonitrile as a mobile phase at a flow rate of 0.4 ml/min with calibration ranges of 0.5–400 and 10–10,000 ng/ml for human plasma and urine, respectively. Rivaroxaban was detected on a triple quadrupole tandem mass spectrometer with an electrospray ionization source in positive ion mode. The methods showed good linearity within the calibration range. The precision and accuracy, matrix effect, extraction recovery and stability in both human matrices were all validated and meet the international guideline requirements. These validated methods were successfully applied to support the TDM of an aged patient receiving rivaroxaban for therapy. 相似文献
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Yanbao Zhao Li Yao Yuanchun Qi Lei Sun Zhishen Wu 《Journal of Sol-Gel Science and Technology》2009,50(1):3-7
Micrometer-sized flowerlike FeS/poly(vinyl pyrrolidone)(PVP) architectures were synthesized by solvothermal process with the
aid of thiourea, in which PVP may serve as soft templates. The FeS/PVP flowers have uniform morphologies with an average diameter
of 5 μm, made of several nanopetals. The formation of FeS/PVP flowers is a new kinetic control process. In this process, thiourea
molecules would be decomposed to produce “gas bubble”, and the “gas bubble” could make PVP chain segment rearrange along exterior
force, resulting in the morphology evolution. The higher “gas bubble” pressure would produce 3D flowers, and the lower pressure
would give a hollow structure. The evolution process from particles to 3D flowers is observed for the first time. In addition,
the hollow FeS/PVP and Cu2S/PVP spheres are also obtained by this technique. 相似文献
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以有机改性聚硅氧烷为单体加入液态电解质通过紫外光辐射固化制备了无机有机杂化聚合物电解质.含有丙烯酸酯端基的有机改性聚硅氧烷单体是通过正硅酸甲酯(TMOS)的水解缩合反应产物与丙烯酸2羟乙酯(HEA)进行脱甲醇反应合成的.它是一种多官能团单体,其结构通过核磁共振氢谱(1HNMR)分析、红外光谱(FTIR)分析及二氧化硅分析进行了表征,分子式可表达为SiO1.143(OH)0.016(OCH3)1.339(OCH2CH2OCOCHCH2)0.357.无机有机杂化聚合物电解质的电化学性能通过交流阻抗和循环伏安法进行了表征.其离子电导率随着液态电解质含量的增大而提高,当液态电解质含量为85wt%时,电导率在22℃为5.5×10-3Scm-1,在-23℃也能达到1.1×10-3Scm-1.界面电阻经过开始2天的增大后达到稳定,电化学稳定窗口超过5.0V,不锈钢电极上锂的电化学沉积与剥离循环可逆性很高. 相似文献
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Zhao Yanbao Sun Lei Tao Xiaojun Zhang Zhijun 《Applied Physics A: Materials Science & Processing》2011,103(1):219-223
A detailed analysis of the optimum regimes of pulsed current metal electrodeposition into pores of porous anodic alumina PAA
is presented. A simple model based on cathodic and anodic current transients is developed. The model is based on a simplified
equivalent circuit consisting of two capacities related to the barrier and porous parts of porous anodic alumina. Nanowires
of Cd, Zn, In, Ni, Co, Ag, and Cu were embedded into PAA by pulsed electrodeposition using an asymmetric rectangular ac signal.
Deposited metal nanowires were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), optical
spectroscopy, Auger electron spectroscopy (AES), and X-ray diffractometry (XRD). 相似文献
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通过在锂离子电池电解液中添加4-溴苯甲醚(4-Bromoanisole, 简称4BA)来提高锂离子电池的过充保护能力. 对电池分别进行了过充实验、循环伏安扫描、红外光谱分析、交流阻抗和容量特性测试, 实验结果表明, 在1 mol8226;L-1 LiPF6/EC+DEC+DMC(质量比1/1/1)中添加5% 的4BA(质量分数)时, 当外加电压为4.4 V(相对于Li/Li+)时, 4BA开始发生电聚合反应且生成高分子聚合物膜, 使电池内阻增大而阻止电压的升高, 从而使电池处于比较安全的状态. 该体系正常充放电过程中, 添加5%的4BA对电池容量特性基本没有影响, 4BA 的防过充机理为阻断机理. 相似文献
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Yanbao Ma Chien‐Pin Sun David A. Haake Bernard M. Churchill Chih‐Ming Ho 《国际流体数值方法杂志》2012,70(6):703-712
A high‐order alternating direction implicit (ADI) method for solving the unsteady convection‐dominated diffusion equation is developed. The fourth‐order Padé scheme is used for the discretization of the convection terms, while the second‐order Padé scheme is used for the diffusion terms. The Crank–Nicolson scheme and ADI factorization are applied for time integration. After ADI factorization, the two‐dimensional problem becomes a sequence of one‐dimensional problems. The solution procedure consists of multiple use of a one‐dimensional tridiagonal matrix algorithm that produces a computationally cost‐effective solver. Von Neumann stability analysis is performed to show that the method is unconditionally stable. An unsteady two‐dimensional problem concerning convection‐dominated propagation of a Gaussian pulse is studied to test its numerical accuracy and compare it to other high‐order ADI methods. The results show that the overall numerical accuracy can reach third or fourth order for the convection‐dominated diffusion equation depending on the magnitude of diffusivity, while the computational cost is much lower than other high‐order numerical methods. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献