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31.
Amit Fischer Avner Ehrlich Yevgeni Plotkin Yu Ouyang Klil Asulin Ioannidis Konstantinos Prof. Chunhai Fan Prof. Yaakov Nahmias Prof. Itamar Willner 《Angewandte Chemie (International ed. in English)》2023,62(43):e202311590
The combination of gene therapy and immunotherapy concepts, along recent advances in DNA nanotechnology, have the potential to provide important tools for cancer therapies. We present the development of stimuli-responsive microcapsules, loaded with a viral immunogenetic agent, harnessing the immune response against the Coronavirus Disease 2019, COVID-19, to selectively attack liver cancer cells (hepatoma) or recognize breast cancer or hepatoma, by expression of green fluorescence protein, GFP. The pH-responsive microcapsules, modified with DNA-tetrahedra nanostructures, increased hepatoma permeation by 50 %. Incorporation of a GFP-encoding lentivirus vector inside the tumor-targeting pH-stimulated miRNA-triggered and Alpha-fetoprotein-dictated microcapsules enables the demonstration of neoplasm selectivity, with approximately 5,000-, 8,000- and 50,000-fold more expression in the cancerous cells, respectively. The incorporation of the SARS-CoV-2 spike protein in the gene vector promotes specific recognition of the immune-evading hepatoma by the COVID-19-analogous immune response, which leads to cytotoxic and inflammatory activity, mediated by serum components taken from vaccinated or recovered COVID-19 patients, resulting in effective elimination of the hepatoma (>85 % yield). 相似文献
32.
Yaakov Rosenfeld 《Journal of statistical physics》1986,42(3-4):437-457
The variational modified-hypernetted-chain (VMHNC) theory, based on the approximation of universality of the bridge functions, is reformulated. The new formulation includes recent calculations by Lado and by Lado, Foiles, and Ashcroft, as two stages in a systematic approach which is analyzed. A variational iterative procedure for solving the exact (diagrammatic) equations for the fluid structure which is formally identical to the VMHNC is described, featuring the theory of simple classical fluids as a one-iteration theory. An accurate method for calculating the pair structure for a given potential and for inverting structure factor data in order to obtain the potentialand the thermodynamic functions, follows from our analysis. 相似文献
33.
Yaakov S. Kupitz 《Discrete and Computational Geometry》1992,7(1):87-103
It is shown that ifS
d
, affS=aff
d
, and every hyperplane spanned by (a subset of)S misses fewer thank points ofS(k2), then (a) #Skm ifd=2m–1 is odd and (b) #Skm+1 ifd=2m is even. We also fully describe the extreme sets for which equality holds in (a) or in (b). For oddd the proofs are later modified to purely algebraic ones, and carry over to
, where
is an arbitrary field. For evend, (b) is generally not true when
, but we prove some weaker inequalities that do hold over arbitrary fields.This is part of a Ph.D. thesis, supervised by Professor Micha A. Perles at the Hebrew University of Jerusalem. This research was supported in part by the Landau Center for Mathematical Research. 相似文献
34.
Einstein's velocity addition formula ofspecial relativity (SR) defines a transformation
v of the ballB
c of radiusc inR
3, representing all possible velocities in an inertial systemK, onto identical ballB
c
, which represents the velocities in another systemK, moving with velocity v relative toK. Since
v maps the zero velocity ofB
c into arbitrary vector v ofB
c
,B
c is homogeneous under all possible
v.A similar homogeneity of the unit ballB inL(G, H) under a set of maps
a, a B, arises also in theLine Transmission Theory (TLT) for a lossless line. HereL(G, H) is the space of all linear operators between Hilbert spacesG,H, representing the signals on the line in the two directions. The explicit form of
a is obtained naturally in TLT. 相似文献
35.
36.
De Santis Emilio Malinovsky Yaakov Spizzichino Fabio 《Methodology and Computing in Applied Probability》2021,23(1):187-205
Methodology and Computing in Applied Probability - The notion of stochastic precedence between two random variables emerges as a relevant concept in several fields of applied probability. When one... 相似文献
37.
38.
Asymptotic behavior of queues is studied for large closed multi-class queueing networks consisting of one infinite server
station with K classes and M processor sharing (PS) stations. A simple numerical procedure is derived that allows us to identify all bottleneck PS stations.
The bottleneck station is defined asymptotically as the station where the number of customers grows proportionally to the
total number of customers in the network, as the latter increases simultaneously with service rates at PS stations. For the
case when K=M=2, the set of network parameters is identified that corresponds to each of the three possible types of behavior in heavy
traffic: both PS stations are bottlenecks, only one PS station is a bottleneck, and a group of two PS stations is a bottleneck
while neither PS station forms a bottleneck by itself. In the last case both PS stations are equally loaded by each customer
class and their individual queue lengths, normalized by the large parameter, converge to uniformly distributed random variables.
These results are directly generalized for arbitrary K=M. Generalizations for K≠M are also indicated. The case of two bottlenecks is illustrated by its application to the problem of dimensioning bandwidth
for different data sources in packet-switched communication networks. An engineering rule is provided for determining the
link rates such that a service objective on a per-class throughput is satisfied.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
39.
40.
Let Y1,…,Yn be the order statistics of a simple random sample from a finite or infinite population, having median =M. We compare the variables |Yj−M| and |Ym−M|, where Ym is the sample median, that is, for odd n. The comparison is in terms of the likelihood ratio order, which implies stochastic order as well as other orders. The results were motivated by the study of best invariant and minimax estimators for the k/N quantile of a finite population of size N, with a natural loss function of the type , where FN is the population distribution function, t is an estimate, and g is an increasing function. 相似文献