基于超临界流体技术制备葡萄糖脂质体的实验研究

脂质体由于其特殊的结构和性能,是一种很有发展潜力的药物载体,在医药和化妆品等行业具有广阔的应用前景。超临界逆向蒸发法是用超临界流体代替有机溶剂制备脂质体的方法,具有对水溶性药物脂质体制备过程简单、包覆率高等特点。以葡萄糖为模型药物,利用该方法制备出了葡萄糖脂质体,并详细考察了不同工艺条件对脂质体粒径和包覆率的影响。结果表明:用超临界逆向蒸发法可成功地制备出最小粒径为290nm、包覆率最高可达41.3%的葡萄糖脂质体。压力、温度和平衡时间对粒径和包覆率都有较大的影响。压力在10~30MPa时,随压力的增加,脂质体粒径显著减小至某一值后,基本趋于稳定,而包覆率逐渐增加,达到25.7%~27.5%,随后包覆率逐渐减小;温度在35~65℃时,随温度的增加粒径显著减小至最小值,然后逐渐增大,而包覆率一直增大,最高可达41.3%;平衡时间在15~45min时,随平衡时间的增加,粒径相对稳定,而包覆率显著增加,超过45min之后,粒径显著增加,包覆率显著下降。     

一个关于勒让德多项式的积分公式及其简单应用——圆形带电环和电流环的静态电磁势

给出了一个关于勒让德多项式的积分公式及其证明,用该公式和叠加法方便快捷地导出了圆形带电环和电流环的静态电磁势.     

64通道一维位置灵敏电流分布探测器及其数据获取系统

针对高流强粒子束与绝缘毛细管相互作用的特点, 设计制作了一套64通道一维位置灵敏电流分布探测器及其配套的数据获取系统, 该探测器可分辨最小直径为1 mm的束斑, 通过数据获取系统可实现可视化自动数据采集。 用2 nA和200—2000 eV电子对探测器进行了定标, 并用10 μA和2000 eV的电子束穿越锥形毛细管后的出射电子, 对探测器及数据获取系统进行测试, 获得了出射粒子的位置分布谱及能量信息。 A 64 channel position sensitive current distribution detector with 1 mm position resolution was developed, while the data acquisition system is based on the LabVIEW software. The test result obtained by using a 2 nA, 200—2000 eV electron beam deflecting by different voltages and the position spectra of 10 μA, 2000 eV electrons transmitted through a glass capillary was measured. The result indicated that the detector can be used to detect the charged particles with strong beam current through the capillary.     

Interference of Two-Component Bose-Einstein Condensates with a Coupling Drive in Presence of Dissipation

The interference of the two-component Bose-Einstein condensates with a coupling drive in the presence of the dissipation is studied. We find that when the two-component Bose-Einstein condensates are initially in the coherent states, for the smaller dissipation parameters compared with that of the rf frequency ωrf, the interference intensity exhibits damply oscillation behavior, whereas when the dissipation parameters are larger than that of the ωry, the interference intensity exhibits a fast attenuation behavior. As a comparison, the interference intensity in the absence of the dissipation is also studied. We conclude that the dissipation of the system can be evaluated by selecting the ωrf experimentally.     

低温大试样热胀系数测试

本介绍了用熔融石英引伸法测量硬质材料热胀系数的简便装置,并给出了试样在液氦温区到室温的测量结果,数据的一致性以及与已有献数据比较取得了不错的结果．     

诺氟沙星与DNA的拉曼光谱研究

报道了诺氟沙星(NFX)及诺氟沙星胶囊内容物的FT-Raman光谱和在银胶基底上的表面增强拉曼光谱(SERS),归属了各个振动;研究了诺氟沙星与DNA的相互作用的SERS,结果表明:胶囊内容物的拉曼光谱图与对照品的拉曼光谱图的特征振动峰:C-F键的伸缩振动,C=C伸缩振动,O-C-O的对称伸缩振动峰值未发生变化,发生变化主要是分子骨架振动峰,诺氟沙星胶囊的辅料对拉曼光谱无实质影响,可建立拉曼光谱法检测诺氟沙星药物的分析方法;诺氟沙星可以在没有金属离子的存在下与DNA直接作用,与DNA相互作用的主要键合模式是插入作用,NFX分子中的平面结构插入DNA的双螺旋碱基平面,为深入了解喹诺酮类抗生素的抗菌机理提供可靠依据.     

Irradiation Test of FPGA for BES-Ⅲ

The irradiation effect of FPGA, applied in Front-end Electronics for experiments of High-Energy Physics, is a serious problem. The performance of FPGA, used in the front-end card of Muon Counters of BES-III project, needs to be evaluated under irradiation. SEUs on Altera ACEX 1K FPGA, observed in the experiment under the irradiation of γ ray, 14 and 2.5MeV neutrons, was investigated. We calculated involved cross-section and provided reasonable analysis and evaluation for the result of the experiment. The conclusion about feasibility of applying ACEX 1K FPGA in the front-end card of the readout system of Muon Counters for BES-III was given.     

Collective Dand Structures in Doubly Odd 136La Nucleus

Using heavy-ion nuclear reaction and in-beam γ-ray spectroscopy technique,high spin states of ¹³⁶La have been studied. The nuclear reaction used is ¹³⁰Te(¹¹B,5n) with a beam energy 60MeV. The level scheme with three collective band structures has been updated with spin up to 20h. The collective backbending has been observed in $\uppi h_{11/2}\otimes \upnu h_{11/2}$ band. According to the TRS calculations,this backbending is due to the alignment of a pair of h_11/2 neutrons. The signature splitting and inversion for the $\uppi h_{11/2}\otimes \upnu h_{11/2}$ band were also discussed. Other two bands based on $12^-$ and $16^+$ levels were proposed as oblate deformation with $\gamma\approx -60^\circ$. They most probably originate from four- and six- quasiparticle configurations, that is,$\uppi h_{11/2}\otimes\upnu g_{7/2} h_{11/2}^2$ and $\uppi g_{7/2}\otimes\upnu g_{7/2}^2 d_{5/2}h_{11/2}^2$ respectively.     

New Explicit Rational Solitary Wave Solutions for Discretized mKdV Lattice Equation

In this letter, we study discretized mKdV lattice equation by using a new generalized ansatz. As a result,many explicit rational exact solutions, including some new solitary wave solutions, are obtained by symbolic computation code Maple.     

基于可调谐光纤激光器的C2H2气体光声光谱检测

研制了基于可调谐掺Er光纤激光器的共振式光声光谱乙炔气体检测系统,结合波长调制和锁相放大器的二次谐波信号检测技术,有效地消除了光声池窗片和池壁吸收入射光而引起的背景噪声,通过对该系统的光学、声学和电子检测系统的优化,实现了低浓度乙炔气体的流动式检测.实验结果证明,当气体浓度较低时,二次谐波振幅与气体浓度成正比,其线性响应相关度达到0.999 53.在常温常压和3.5 mW平均光功率以及100 ms锁相积分时间条件下,乙炔气体的极限检测灵敏度达到了0.3 ppm(1 ppm=1μg·mL-1)(SNR=1时),系统用可调谐掺Er光纤激光器代替半导体激光器作光源,降低了成本,为发展低成本、实用、便携式微量气体光谱榆测仪器奠定了基础.若采用多光程光声池,或者采用EDFA提高激光功率,可大幅度提高信噪比,将极限检测灵敏度提高至ppb(1 ppb=1 ng·mL-1)量级.